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2023 (11)
Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice. Yamamoto K, Watanabe-Takano H, Oguri-Nakamura E, Matsuno H, Horikami D, Ishii T, Ohashi R, Kubota Y, Murata T, Mochizuki N, Fukuhara S. FASEB J. 2023Enhancement of prostaglandin D2-D prostanoid 1 signaling reduces intestinal permeability by stimulating mucus secretion. Hayashi A, Sakamoto N, Kobayashi K, *Murata T. Front Immunol. 14.1276852.2023.
Alleviation of allergic conjunctivitis by (±)5(6)-dihydroxy-8Z,11Z,14Z,17Zeicosatetraenoic acid in mice. #Nagata N, #Suzuki T, Takenouchi S, Kobayashi K, *Murata T. Front. Pharmacol. 14:1217397.2023.
Roles of Lipocalin-type and Hematopoietic Prostaglandin D Synthases in Mouse Retinal Angiogenesis. Horikami D, Sekihachi E, Omori K, Kobayashi Y, Kobayashi K, Nagata N, Kurata K, Uemura A, *Murata T. J Lipid Res. 100439.2023.
Behavioral changes of food allergic model mice during light and dark period. Miyazaki Y, Kobayashi K, *Murata T. J Pharmacol Sci. 153.113-118.2023.
Production profile of lipid mediators in conjunctival lavage fluid in allergic and infectious conjunctivitis in guinea pigs. Hayashi A, Kobayashi K, Nakamura T, Nagata N, *Murata T. Front Allergy. 4:1218447.2023.
Mast cell-derived prostaglandin D2 limits the subcutaneous absorption of honey bee venom in mice. Fujiwara Y, Nakamura T, Maehara T, Hayashi A, Aritake K, Murata T. Proc Natl Acad Sci U S A. 120(22):e2300284120.2023.
The development of methods to evaluate experimental animal behavior using images. Sakamoto N, Miyazaki Y, Kobayashi K, Minato T, Murata T. Nihon Yakurigaku Zasshi. 158(2):182-186. 2023.
Marker-less tracking system for multiple mice using Mask R-CNN. Sakamoto N, Kakeno H, Ozaki N, Miyazaki Y, Kobayashi K, *Murata T. Front Behav Neurosci. 16:1086242. 2023.
12-HETE promotes late-phase responses in a murine model of allergic rhinitis. Nakamura T, Tachibana Y, *Murata T. Allergy. 78(2):574-577. 2023.
How does dysbiosis cause allergic diseases? Suzuki K, Murata T. Nihon Yakurigaku Zasshi. 158(1):102. 2023.
2022（14）
The effect of exposure on cattle thyroid after the Fukushima Daiichi nuclear power plant accident. Horikami D, Sayama N, Sasaki J, Kusuno H, Matsuzaki H, Hayashi A, Nakamura T, Satoh H, Natsuhori M, Okada K, Ito N, Sato I, *Murata T. Sci Rep. 12(1):21754. 2022.Association of age, allergic rhinitis, and regular food intake with urinary tetranor-PGD metabolite levels. Shimada M, Yamamoto-Hanada K, Inuzuka Y, Kabashima S, Nakamura T, Shimosawa T, Murata T, *Ohya Y. J Lab Precis Med 2022. 7:36. 2022.
Urinary lipid profile of patients with COVID-19. Kida M, Nakamura T, Kobayashi K, Shimosawa T, *Murata T. Front Med 9:941563. 2022.
Urinary lipid production profile in canine patients with splenic mass. Kida T, Yamazaki A, Nakamura T, Kobayashi K, Yoshimoto S, Maeda S, Nakagawa T, Nishimura R, *Murata T. J Vet Med Sci. 2022. 1;84(11):1480-1484. 2022.
Development and application of animal behavior analysis system using video images. Sakamoto N, Miyazaki Y, Kobayashi K, *Murata T. Trans Reg Scie. 2022. 4(1): 25–29. 2022.
Analytical technologies of animal behavior using artificial intelligence. Sakamoto N, *Murata T. Nihon Yakurigaku Zasshi. 2022;157(2):156.
Automated scratching detection system for black mouse using deep learning. Sakamoto N, Haraguchi T, Kobayashi K, Miyazaki Y, *Murata T. Front Physiol. 13:939281. 2022.
Comprehensive profiling of lipid metabolites in urine of canine patients with liver mass. Kida T, Yamazaki A, Nakamura T, Kobayashi K, Yoshimoto S, Maeda S, Nakagawa T, Nishimura R, *Murata T. J Vet Med Sci. 84(8):1074-1078. 2022.
A novel anti-inflammatory lipid mediator 5,6-DiHETE. Takenouchi S, *Murata T. Trans Reg Scie. 4(2): 37-39. 2022.
The Urinary Lipid Profile in Cats with Idiopathic Cystitis. Takenouchi S, Kobayashi Y, Shinozaki T, Kobayashi K, Nakamura T, Yonezawa T, *Murata T. J Vet Med Sci. 2022. 84(5):689-693. 2022.
An Assessment of the Spontaneous Locomotor Activity of BALB/c Mice. Miyazaki Y, Kobayashi K, Matsushita S, Shimizu N, *Murata T. J Pharmacol Scie. 149(2):46-52. 2022.
The profile of urinary lipid metabolites in healthy dogs. Kida T, Yamazaki A, Kobayashi K, Nakamura T, Nakagawa T, Nishimura R, *Murata T. J Vet Med Sci. 2022. 84(5):644-647. 2022.
Automated Grooming Detection of Mouse by Three-Dimensional Convolutional Neural Network. Sakamoto N, Kobayashi K, Yamamoto T, Masuko S, Yamamoto M, *Murata T. Front Behav Neurosci. 2022. 16:797860. 2022.
15-hydroxy eicosadienoic acid is an exacerbating factor for nasal congestion in mice. Miyata K, Horikami D, Tachibana Y, Yamamoto T, Nakamura T, Kobayashi K, *Murata T. FASEB J. 36(1):e22085. 2022.
2021（14）
The profile of urinary lipid metabolites in cats with bacterial cystitis. #Kobayashi Y, #Nakamura T, Yonezawa T, Kobayashi K, *Murata T. J Vet Med Sci. 2021. Dec; 83(12): 1977–1981.Urinary lipid profile of atopic dermatitis in murine model and human patients. Nagata N, Hamasaki Y, Inagaki S, Nakamura T, Horikami D,Yamamoto-Hanada K, Inuzuka Y, Shimosawa T, Kobayashi K, Narita M, Ohya Y, *Murata T. FASEB J. 35(11):e21949. 2021.
8-iso-prostaglandin E2 induces nasal obstruction. Nakamura T, Tachibana Y, *Murata T. FASEB J. 35(10):e21941. 2021.
Efficient Attenuation of Dextran Sulfate Sodium-Induced Colitis by Oral Administration of 5,6-Dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic Acid in Mice. Takenouchi S, Imai D, Nakamura T, *Murata T. Int. J. Mol. Sci.,22(17), 9295.2021
L-PGDS attenuates acute lung injury by PGD2 in both dependent and independent ways. Horikami D, Fuji W, Aritake K, and *Murata T. J Immunol ji2100394. 2021.
Detection of allergy reactions during oral food challenge using noninvasive urinary prostaglandin D2 metabolites. Inuzuka Y, Yamamoto-Hanada K, Nakamura T.Shimosawa T. *Murata T. Ohya Y. Clin Exp Allergy.00:1-4.2021.
Urinary prostaglandin D2 metabolite appears to be a useful biomarker for evaluating the status of egg oral immunotherapy in children. Inagaki S, Nakamura T, Natsume O, Yamamoto-Hanada K, Fukuie T, Narita M, Shimosawa T, *Murata T, *Ohya Y. JACI in practice. S2213-2198(21)00771-6. 2021.
Extraction and measurement of urinary tetranor-PGDM in disposable diapers. Ito N, Nakamura T, Sakamoto N, Hayashi A, *Murata T. J Pharmacol Scie. 2021. 147(2): 208-210,2021.
PGD2/CRTH2 signaling promotes acquired immunity against bee venom by enhancing IgE production. Kida M, Nakamura T, Fujiwara Y, Nakamura M, *Murata T. FASEB J. 35(6):e21616. 2021.
Development of monoclonal antibody-based EIA for tetranor-PGDM which reflects PGD2 production in the body. Nagata N, Masuko S, Inoue R, Nakamura T, Aritake K, *Murata T. J Immunol Res. 5591115. 2021.
Urinary 8-iso PGF2α and 2,3-dinor-8-iso PGF2α can be indexes of colitis-associated colorectal cancer in mice. Miyazaki Y, Nakamura Y, Takenouchi S, Hayashi A, Omori K, Murata T. PLoS One. 2021 Jan 27;16(1):e0245292.
5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid accelerates the healing of colitis by inhibiting transient receptor potential vanilloid 4-mediated signaling. Kobayashi K, Ashina K, Sandra D, Hamabata T, Nakamura T, Nagata N, Takenouchi S, Tominaga M, *Murata The FASEB journal. 2021 Apr;35(4):e21238.
Prostaglandin D2 metabolite is not a useful clinical indicator for assessing atopic dermatitis. Inagaki S, Nakamura T, Hamasaki Y, Yamamoto-Hanada K, Fukuie T, Narita M, Shimosawa T, *Murata T, Ohya Y. Clinical and Experimental Dermatology. 2021 Jan;46(1):130-134.
Automated detection of mouse scratching behaviour using convolutional recurrent neural network. Kobayashi K, Matsushita S, Shimizu N, Masuko S, Yamamoto M, *Murata T. Scientific Reports. 2020. 12;11(1):658. 2021.
2020（10）
Prostanoids regulate vascular permeability. Horikami D, Kobayashi K, *Murata T. Nihon Yakurigaku Zasshi. 155(6):395-400. 2020.A mechanisms of drug resistance in tumor endothelial cells. Kobayashi Y, Nakamura T, Miyazaki Y, Omori K, Kobayashi K, *Murata T. Nihon Yakurigaku Zasshi. 155(5):351. 2020.
Assessments of DNA Damage and Radiation Exposure Dose in Cattle Living in the Contaminated Area Caused by the Fukushima Nuclear Accident. *Sato I, Sasaki J, Satoh H, Natsuhori M, Murata T, Okada K. Bull Environ Contam Toxicol. 105(3):496-501. 2020.
Prostaglandin D2 metabolite is not a useful clinical indicator for assessing atopic dermatitis. Inagaki S, Nakamura T, Hamasaki Y, Yamamoto-Hanada K, Fukuie T, Narita M, Shimosawa T, *Murata T, *Ohya Y. Clin Exp Dermatol. Jan;46(1):130-134. 2020.
Defensive reaction against bee venom. Kida M, Nakamura T, Fujiwara Y, *Murata T. Nihon Yakurigaku Zasshi. 2020;155(4):277. 2020.
The profile of lipid metabolites in urine of marmoset wasting syndrome. Yamazaki A, Nakamura T, Miyabe-Nishiwaki T, Hirata A, Inoue R, Kobayashi K, Miyazaki Y, Hamasaki Y, Ishigami A, Nagata N, Kaneko A, Koizumi M, Ohta H, Okano HJ, *Murata T. PLoS One. 23;15(6):e0234634. 2020.
The profile of urinary lipid metabolites in cats. Kobayashi Y, Nakamura T, Kobayashi K, *Murata T. J Vet Med Sci. 82(7):1017-1020. 2020.
A novel eicosapentaenoic acid-derived anti-inflammatory lipid mediator 5,6-DiHETE is abundant in blue back fish intestines. Kida M, Nakamura T, *Murata T. Journal of Food Science. 85(7):1983-1987. 2020.
The assessment of mouse spontaneous locomotor activity using motion picture. Kobayashi K, Shimizu N, Matsushita S, *Murata T. Journal of Pharmacological Sciences. S1347-8613(20)30015-3. 2020.
A new zinc chelator, IPZ-010 ameliorates postoperative ileus. Kimura H, Yoneya Y, Mikawa S, Kaji N, Ito H, Tsuchida Y, Komatsu H, Murata T, Ozaki H, Uchida R, Nishida K, *Hori M. Biomed Pharmacother. 123:109773. 2020.
2019（7）
Epithelial cell-derived prostaglandin D2 inhibits chronic allergic lung inflammation in mice. Maehara T, Nakamura T, Maeda S, Aritake K, Nakamura M, *Murata T. FASEB J. fj201802817R. 2019.Production of lipid mediators in mastitic milk of cow. Hayashi A, Fujii S, Nakamura T, Kobayashi K, Sakatani M, Endo M, Takahashi T, Murata T. Animal Science Journal. 90(8)999-1007. 2019.
Pathological characteristics of thyroid glands from Japanese Black Cattle living in the restricted area of the Fukushima Daiichi Nuclear Power Plant accident. *Sasaki J, Uehara M, Sato I, Satoh H, Deguchi Y, Chida H, Natsuhori M, Murata T, Ochiai K, Otani K, Okada K, Ito N. Animal Science Journal. 90(9):1333-1339: 2019.
Comparison of urine and blood as a convenient and practical sample for estimating the contamination level of live cattle with radioactive cesium. Sato I, Sasaki J, Satoh H, Natsuhori M, Murata T, Okada K. Animal Science Journal. 90(8):1090-1095. 2019.
L-PGDS-derived PGD2 attenuates acute lung injury by enhancing endothelial barrier formation. #Horikami D, #Toya N, Kobayashi K, Omori K, Nagata N, *Murata T. J Pathol. 248(3):280-290. 2019.
Therapeutic potential of D prostanoid receptor 1 signal enhancement in a murine model of food allergy. #Nakamura T and #Hirai R, Tachibana Y, Masuko S, Nagata N, *Murata T. J Allergy Clin Immunol. 143(6):2290-2293. 2019.
Hematopoietic prostaglandin D synthase-derived prostaglandin D2 ameliorates adjuvant-induced joint inflammation in mice. Tsubosaka Y, Maehara T, Imai D, Nakamura T, Kobayashi K, Nagata N, Fujii W, *Murata T. FASEB J. fj201802153R. 2019.
2018（9）
Inhibition of stromal cell-derived factor-1α/CXCR4 signaling restores the blood-retina barrier in pericyte-deficient mouse retinas. Omori K, Nagata N, Kurata K, Fukushima Y, Sekihachi E, Fujii N, Namba-Hamano T, Takabatake Y, Fruttiger M, Nagasawa T, Uemura A, *Murata T. JCI insight. 3(23).120706. 2018.5,6-DiHETE attenuates vascular hyperpermeability by inhibiting Ca2+ elevation in endothelial cells. Hamabata T, Nakamura T, Tachibana Y, Horikami D, *Murata T. J Lipid Res. 59(10). 1864-1870. 2018.
The roles of mast cells in tumor microenvironment. Yamazaki A, Kobayashi K, *Murata T. Nihon Yakurigaku Zasshi. 152(3):160-162. 2018.
Role of prostaglandins in tumor microenvironment. Kobayashi K, Omori K, *Murata T. Cancer Metastasis Rev. 2018. doi: 10.1007/s10555-018-9740-2.
Urinary PGDM, a prostaglandin D2 metabolite, is a novel biomarker for objectively detecting allergic reactions of food allergy. Inagaki S, Maeda S, Narita M, Nakamura T, Shimosawa T, *Murata T and *Ohya Y.J Allergy Clin Immunol. S0091-6749(18)30995-3.2018.
Regulation of vascular permeability in anaphylaxis. Nakamura T, *Murata T. British Journal of Pharmacology. 175(13):2538-2542. 2018.
The roles of IgE in allergic diseases. Hayashi A, Nakamura T, *Murata T.Nihon Yakurigaku Zasshi. 151(3):130.2018.
Production of lipid mediators across different disease stages of dextran sulfate sodium-induced colitis in mice. Hamabata T, Nakamura T, Masuko S, Maeda S, *Murata T. Journal of Lipid Research. 59(4):586-595.2018.
Lipocalin-type prostaglandin D synthase-derived PGD2 attenuates malignant properties of endothelial cells in tumor. Omori K, Morikawa T, Kunita A, Nakamura T, Aritake K, Urade Y, Fukayama M, *Murata T.Journal of Pathology.244(1):84-96.2018.
2017（5）
Prostaglandin D2 metabolite in urine is an index of food allergy. Maeda S, Nakamura T, Harada H, Tachibana Y, Aritake K, Shimosawa T, Yatomi Y, *Murata T. Scientific Reports. 7(1):17687.2017.Mast cell-derived PGD2 attenuates anaphylactic reactions in mice. Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, *Murata T.J Allergy Clinical Immunology.140(2):630-632.e9. 2017.
The role of mast cell in inflammation. Yamazaki A, Nakamura T, Omori K, *Murata T.Nihon Yakurigaku Zasshi.2017;149(5):204-207.
Pathological findings of Japanese Black Cattle living in the restricted area of the Fukushima Daiichi Nuclear Power Plant accident, 2013-2016. *Sasaki J,Hiratani K, Sato I, Satoh H, Deguchi Y, Chida H, Natsuhori M, Ochiai K,Otani K, Okada K, Ito N.Animal Science Journal.88(12):2084-2089.2017.
Radioactive cesium and potassium in cattle living in the 'zone in preparation for the lifting of the evacuation order' of the Fukushima nuclear accident. *Sato I, Sasaki J, Satoh H, Murata T, Otani K, Okada K. Animal Science Journal. 88(7):1021-1026.2017.
2016（6）
Prostaglandin D2 Attenuates Bleomycin-induced Lung Inflammation and Pulmonary Fibrosis. Kida T#, Ayabe S#, Omori K, Nakamura T, Maehara T, Aritake K, Urade Y, *Murata T. PLoS One. 11(12):e0167729.2016.Thromboxane A2 exacerbates acute lung injury via promoting edema formation. #Kobayashi K, #Horikami D, Omori K, Nakamura T, Yamazaki A, Maeda S,*Murata T. Scientific Reports. 6:32109.2016.
Discovery of anti-inflammatory role of prostaglandin D2. *Murata T, Maehara T. J Vet Med Sci. 2016.78(11):1643-1647.2016.
Nitric oxide-induced oxidative stress impairs pacemaker function of murine interstitial cells of Cajal during inflammation. Kaji N, Horiguchi K, Iino S, Nakayama S, Ohwada T, Otani Y, Firman, Murata T, Sanders KM, Ozaki H, *Hori M. Pharmacol Res. S1043-6618(16)30224-9 2016.
Local varlation of soil contamination with radioactive cesium at a farm in Fukushima. *Sato I, Natsuhori M, Sasaki J, Satoh H, Murata T, Nakamura T, Otani K, Okada K. Jap J of Vet Res. 64(1):98-99 2016.
The new zinc chelator IPZ-010 ameliorates postoperative ileus. Kimura H, Yoneya Y, Mikawa S, Kaji N, Ito H, Tsuchida Y, Komatsu H, Murata T, Ozaki H, Nishida K, *Hori M. British J Pharmacol. 123,109773,2020.
2015（8）
Physiological role of mast cell. Nakamura T, *Murata T. Nihon Yakurigaku Zasshi. 146(6):349 2015.Discovery of anti-inflammatory role of prostaglandin D. *Murata T. Nihon Yakurigaku Zasshi.146(4):201-7. 2015.
Characteristics of tumor endothelial cells. Omori K, *Murata T.Nihon Yakurigaku Zasshi 146(3):174 2015.
PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi B, Iwakura Y, Urade Y, *Murata T.
Nature Communications. 6:7514 2015.
VEGF-induced blood flow increase causes vascular hyper-permeability in vivo. Ashina K, Tsubosaka Y, Kobayashi K, Omori K, *Murata T. Biochem Biophys Res Commun. S0006-291X(15)30245-X 2015.
Histamine induces vascular hyperpermeability by increasing blood flow and endothelial barrier disruption in vivo. Ashina K, Tsubosaka Y, Nakamura T, Omori K, Kobayashi K, Hori M, Ozaki H, *Murata T. PLoS One. 10(7):e0132367 2015.
Time-dependent changes in inhibitory action of lipopolysaccharide on intestinal motility in rat. Mikawa S, Ohta Y, Kaji N, Islam MS, Murata T, Ozaki H, *Hori M.
J Vet Med Sci. 1;77(11):1443-9 2015.
Anti-emetic drug maropitant induces intestinal motility disorder but not anti-inflammatory action in mice. Mikawa S, Yamamoto S, Islam MS, Kaji N, Murata T, Mizuno R, Ozaki H, *Hori M. J Vet Med Sci.77(10):1195-9 2015.
2014 （10）
Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in postoperative ileus. Maehara T, Matsumoto K, Horiguchi K, Kondo M, Iino S, Horie S, Murata M, Tsubone H, Shimada S, Ozaki H, *Hori M. British J Pharmacol. 172(4):1136-47 2014.A Deficiency in the Prostaglandin D2 Receptor CRTH2 Exacerbates Adjuvant-induced Joint Inflammation. Tsubosaka Y, Nakamura T, Hirai H, Hori M, Nakamura M, Ozaki H, *Murata T. J Immunology. 193(12):5835-40 2014.
IL-17A Induces Hypo-contraction of Intestinal Smooth Muscle via Induction of iNOS in Muscularis Macrophages. Mori D, Watanabe N, Kaminuma O, Murata T, Hiroi T, Ozaki H, *Hori M. J Pharmacol Sci. 125(4):394-405 2014.
Tumor Supressor Prostaglandin D2. Maeda S, Nakamura T, *Murata T. Oncoscience. 1(6):396-7 2014.
SDF-1α-CXCR4 Axis Promotes Endothelial Cell Barrier Integrity via PI3kinase and Rac1 activation. #Kobayashi K, #Sato K, Kida T, Omori K, Hori M, Ozaki H, *Murata T. Arterioscler Thromb Vasc Biol. 34(8):1716-22 2014 # equally contributed
Mast Cell-Derived Prostaglandin D2 Inhibits Colitis and Colitis-Associated Colon Cancer in Mice. Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, *Murata T. Cancer Res. 74(11):3011-9 2014
Multiple roles of prostaglandin E2-EP signal in vascular permeability. Omori K, Kida T, Hori M, Ozaki H, *Murata T. British J Pharmacol. 171(21):4879-89 2014.
Dynamin-2 regulation of integrin endocytosis, but not VEGF signaling, is critical for developmental angiogenesis. Lee M, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano A, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood D, Ferguson S, DeCamilli P, *Sessa WC. Development. 141(7):1465-72 2014.
Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation. Sarashina H, Tsubosaka Y, Omori K, Aritake K, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H, *Murata T. J Immunology. 192(1):459-65 2014.
Stimulation of G Protein-coupled Bile Acid Receptor Enhances Vascular Endothelial Barrier Function via Activation of PKA and Rac1. Kida T, Omori K, Hori M, Ozaki H, *Murata T. The Journal of Pharmacology and Experimental Therapeutics. 348(1):125-30 2014.
2013 （9）
PDGF and TGF-beta promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice. Islam MS, Kusakabe M, Horiguchi K, Iino S, Nakamura T, Iwanaga K, Hashimoto H, Matsumoto S, Murata T, Hori M, *Ozaki H. British Journal of Pharmacology. 171(2):375-88 2013.eNOS derived nitric oxide regulates endothelial barrier function via VE cadherin and Rho GTPases. DiLorenzo A, Lin M, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang P, *Sessa WC. Journal of Cell Science. 126(Pt 24):5541-52. 2013.
UDP promotes intestinal epithelial migration via the P2Y6 receptor. Nakamura T, Murata T, Hori M, *Ozaki H. British Journal of Pharmacology. 170(4):883-92 2013.
Diverse effects of prostaglandin E2 on vascular contractility. Kida T, Sawada K, Kobayashi K, Hori M, Ozaki H, *Murata T. Heart Vessels. 29(3):390-5. 2014.
Bile Acid Receptor TGR5 Agonism Induces NO Production and Reduces Monocyte Adhesion in Vascular Endothelial Cells. Kida T, Tsubosaka Y, Hori M, Ozaki H, *Murata T.
Arterioscler Thromb Vasc Biol. 33(7):1663-9 2013.
Prostaglandin D2-DP Signaling Promotes Endothelial Barrier Function via the cAMP/PKA/Tiam1/Rac1 Pathway. Kobayashi K, Tsubosaka Y, Hori M, Narumiya S, Ozaki H, *Murata T. Arterioscler Thromb Vasc Biol. 33(3) 565-571 2013.
Purinergic P2Y1 receptor signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts. Iwanaga K, *Murata T, Hori M, Ozaki H. European Juornal of Pharmacology. 702(1-3) 158-164 2013.
Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. *Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H. Proceedings of the National Academy of Sciences of the United States of America. 110(13):5205-10 2013.
Prostaglandin D2 inhibits collagen secretion from lung fibroblasts by activating DP receptor. Ayabe S, Kida T, Hori M, Ozaki H, *Murata T. Journal of Pharmacological Sciences. 121(4) 312-317 2013.
2012 （3）
γ-Oryzanol reduces adhesion molecule expression in vascular endothelial cells via suppression of nuclear factor-κB activation. Sakai S, *Murata T, Tsubosaka Y, Ushio H, Hori M, Ozaki H. Journal of Agricultural and Food Chemistry. 60 3367-3372 2012.EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals. Tajima T, Murata T, Aritake K, Urade Y, Michishita M, Matsuoka T, Narumiya S, Ozaki H, *Hori M. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302 G524-34 2012.
Prostaglandin E2 promotes wound-induced migration of intestinal subepithelial myofibroblasts via EP2, EP3, and EP4 prostanoid receptor activation. Iwanaga K, Okada M, *Murata T, Hori M, Ozaki H. The Journal of Pharmacology and Experimental Therapeutics. 340 604-611 2012.
2011（10）
Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. *Murata T, Aritake K, Matsumoto S, Kamauchi S, Nakagawa T, Hori M, Momotani E, Urade Y, Ozaki H.Proceedings of the National Academy of Sciences of the United States of America. 108 19802-19807 2011.Synchronous phosphorylation of CPI-17 and MYPT1 is essential for inducing Ca2+ sensitization in intestinal smooth muscle. Mori D, *Hori M, Murata T, Ohama T, Kishi H, Kobayashi S, Ozaki H. Neurogastroenterology and motility. 23 1111-1122 2011.
Effect of N-(p-coumaroyl)serotonin and N-feruloylserotonin, major anti-atherogenic polyphenols in safflower seed, on vasodilation, proliferation and migration of vascular smooth muscle cells. Takimoto T, Suzuki K, Arisaka H, Murata T, Ozaki H, *Koyama N. Molecular Nutrition Food rResearch. 55 1561-1571 2011.
Prostaglandin E2-prostanoid EP3 signal induces vascular contraction via nPKC and ROCK activation in rat mesenteric artery. Kobayashi K, *Murata T, Hori M, Ozaki H. European Journal of Pharmacology. 660 375-380 2011.
Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways. Iizuka M, Murata T, Hori M, *Ozaki H. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300 G1010-21 2011.
Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus. Tsuchida Y, Hatao F, Fujisawa M, Murata T, Kaminishi M, Seto Y, *Hori M, Ozaki H. Gut. 60 638-647 2011.
ATP induces contraction mediated by the P2Y(2) receptor in rat intestinal subepithelial myofibroblasts. Nakamura T, Iwanaga K, Murata T, Hori M, *Ozaki H. European Journal of Pharmacology. 657 152-158 2011.
iNOS expression in vascular resident macrophages contributes to circulatory dysfunction of splanchnic vascular smooth muscle contractions in portal hypertensive rats. Kajita M, Murata T, Horiguchi K, Iizuka M, *Hori M, Ozaki H.American Journal of Physiology. Heart and Circulatory Physiology. 300 H1021-31 2011.
Chronic treatment with PDGF-BB and endothelin-1 synergistically induces vascular hyperplasia and loss of contractility in organ-cultured rat tail artery. Kida T, Chuma H, *Murata T, Yamawaki H, Matsumoto S, Hori M, Ozaki H. Atherosclerosis. 214 288-294 2011.
Relaxant effect of prostaglandin D(2)--receptor DP agonist on liver myofibroblast contraction. Maruyama T, Ayabe S, *Murata T, Hori M, Ozaki H. Journal of Pharmacological Sciences. 116 197-203 2011.
2010 （4）
The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage. Fujisawa M, Murata T, Hori M, *Ozaki H. Journal of Gastroenterology. 45 179-186 2010.Halichlorine is a novel L-type Ca2+ channel inhibitor isolated from the marine sponge Halichondria okadai Kadota. Tsubosaka Y, *Murata T, Kinoshita K, Yamada K, Uemura D, Hori M, Ozaki H. European Journal of Pharmacology. 628 128-131 2010.
Halichlorine reduces monocyte adhesion to endothelium through the suppression of nuclear factor-kappaB activation. Tsubosaka Y, *Murata T, Yamada K, Uemura D, Hori M, Ozaki H. Journal of Pharmacological Sciences. 113 208-213 2010.
Isolation and characterization of bovine intestinal subepithelial myofibroblasts. Iwanaga K, *Murata T, Hori M, Ozaki H. Journal of Pharmacological Sciences. 112 98-104 2010.
2009 （7）
Antioxidant, free radical-scavenging, and NF-kappaB-inhibitory activities of phytosteryl ferulates: structure-activity studies. Islam MS, Yoshida H, Matsuki N, Ono K, Nagasaka R, Ushio H, Guo Y, Hiramatsu T, Hosoya T, Murata T, Hori M, *Ozaki H. Journal of Pharmacological Sciences. 111 328-337 2009.The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Schleicher M, Yu J, Murata T, Derakhshan B, Atochin D, Qian L, Kashiwagi S, Di Lorenzo A, Harrison KD, Huang PL, *Sessa WC. Science Signaling. 2 ra41 2009.
Carbachol induces Ca2+-dependent contraction via muscarinic M2 and M3 receptors in rat intestinal subepithelial myofibroblasts. Iwanaga K, *Murata T, Okada M, Hori M, Ozaki H. Journal of Pharmacological Sciences. 110 306-314 2009.
Time-dependent phenotypic and contractile changes of pulmonary artery in chronic hypoxia-induced pulmonary hypertension. Aoshima D, Murata T, Hori M, Ozaki H. Journal of Pharmacological Sciences. 110 182-190 2009.
Prostaglandin E2 induces contraction of liver myofibroblasts by activating EP3 and FP prostanoid receptors. Ayabe S, *Murata T, Maruyama T, Hori M, Ozaki H. British Journal of Pharmacology. 156 835-845 2009.
Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level. Fujimoto M, Oka T, Murata T, *Hori M, Ozaki H. European Journal of Pharmacology. 602 432-438 2009.
Chronic stimulation of farnesoid X receptor impairs nitric oxide sensitivity of vascular smooth muscle. Kida T, *Murata T, Hori M, Ozaki H. American journal of physiology. Heart and circulatory physiology. 296 H195-201 2009.
2008 （6）
Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo. *Murata T, Lin MI, Aritake K, Matsumoto S, Narumiya S, Ozaki H, Urade Y, Hori M, Sessa WC. Proceedings of the National Academy of Sciences of the United States of America. 105 20009-20014 2008.Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts. Ohama T, Okada M, Murata T, Brautigan DL, Hori M, *Ozaki H. American Journal of Physiology. Gastrointestinal and liver physiology. 295 G766-75 2008.
Prostaglandin D2 induces contraction via thromboxane A2 receptor in rat liver myofibroblasts. Maruyama T, *Murata T, Ayabe S, Hori M, Ozaki H. European Journal of Pharmacology. 591 237-242 2008.
Lipopolysaccharide induces macrophage migration via prostaglandin D2 and prostaglandin E2. Tajima T, Murata T, Aritake K, Urade Y, Hirai H, Nakamura M, Ozaki H, *Hori M. The Journal of Pharmacology and Experimental Therapeutics. 326 493-501 2008.
Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice. Islam MS, Murata T, Fujisawa M, Nagasaka R, Ushio H, Bari AM, Hori M, *Ozaki H. British Journal of Pharmacology. 154 812-824 2008.
Downregulation of CPI-17 contributes to dysfunctional motility in chronic intestinal inflammation model mice and ulcerative colitis patients. Ohama T, Hori M, Fujisawa M, Kiyosue M, Hashimoto M, Ikenoue Y, Jinno Y, Miwa H, Matsumoto T, Murata T, *Ozaki H. Journal of Gastroenterology. 43 858-865 2008.
~2007（23）
Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Fernandez-Hernando C, Ackah E, Yu J, Suarez Y, Murata T, Iwakiri Y, Prendergast J, Miao RQ, Birnbaum MJ, *Sessa WC. Cell Metabolism. 6 446-457 2007.Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. Bernatchez PN, Acevedo L, Fernandez-Hernando C, Murata T, Chalouni C, Kim J, Erdjument-Bromage H, Shah V, Gratton JP, McNally EM, Tempst P, *Sessa WC. The Journal of Biological Chemistry. 282 30745-30753 2007.
Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. Murata T, Lin MI, Huang Y, Yu J, Bauer PM, Giordano FJ, *Sessa WC. Journal of Experimental Medicine. 204(10) 2373-2382 2007.
Different profiles of Ca2+ responses to endothelin-1 and PDGF in liver myofibroblasts during the process of cell differentiation. Kojima N, Hori M, Murata T, Morizane Y, *Ozaki H. British Journal of Pharmacology. 151 816-827 2007.
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. Atochin DN, Wang A, Liu VW, Critchlow JD, Dantas AP, Looft-Wilson R, Murata T, Salomone S, Shin HK, Ayata C, Moskowitz MA, Michel T, *Sessa WC, *Huang PL. The Journal of Clinical Iinvestigation. 117 1961-1967 2007.
Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. Murata T, Lin MI, Stan RV, Bauer PM, Yu J, *Sessa WC. The Journal of Biological Chemistry. 282 16631-16643 2007.
Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Lin MI, Yu J, Murata T, *Sessa WC. Cancer research. 67 2849-2856 2007.
Altered intracellular eNOS localization leads to an excessive no production in the splanchnic arterial circulation in cirrhotic rats with portal hypertension. Iwakiri Y, Murata T, Gao H, Loureiro-Silva M, Sessa WC, *Groszmann RJ. Hepatology. 44 354A-354A 2006.
Canine distemper virus induces apoptosis through caspase-3 and -8 activation in vero cells. Kajita M, Katayama H, Murata T, Kai C, Hori M, *Ozaki H. Journal of Veterinary Medicine. 53 273-277 2006.
Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels.Yu J, Bergaya S, Murata T, Alp IF, Bauer MP, Lin MI, Drab M, Kurzchalia TV, Stan RV, *Sessa WC. The Journal of Clinical Investigation. 116 1284-1291 2006.
Intestinal gene expression in TNBS treated mice using genechip and subtractive cDNA analysis: implications for Crohn's disease. Yamamoto S, Isuzugawa K, Takahashi Y, Murase Y, Iwata M, Arisawa T, Nakano H, Nishimura N, Yamato S, Ohta M, Ina K, Murata T, Hori M, Ozaki H, *Imakawa K. Biological Pharmaceutical Bulletin. 28 2046-2053 2005.
Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension. *Murata T, Kinoshita K, Hori M, Kuwahara M, Tsubone H, Karaki H, Ozaki H. Arteriosclerosis, Thrombosis, and Vascular Biology. 25 2335-2342 2005.
Vascular endothelium has a local anti-adenovirus vector system and glucocorticoid optimizes its gene transduction. *Murata T, Hori M, Lee S, Nakamura A, Kohama K, Karaki H, Ozaki H. Arteriosclerosis, Thrombosis, and Vascular Biology. 25 1796-1803 2005.
Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. Yu J, deMuinck ED, Zhuang Z, Drinane M, Kauser K, Rubanyi GM, Qian HS, Murata T, Escalante B, *Sessa WC. Proceedings of the National Academy of Sciences of the United States of America. 102 10999-11004 2005.
Dexamethasone prevents impairment of endothelium-dependent relaxation in arteries cultured with fetal bovine serum. *Murata T, Suzuki N, Yamawaki H, Sato K, Hori M, Karaki H, Ozaki H. European Journal of Pharmacology. 515 134-141 2005.
Fluvastatin prevents vascular hyperplasia by inhibiting phenotype modulation and proliferation through extracellular signal-regulated kinase 1 and 2 and p38 mitogen-activated protein kinase inactivation in organ-cultured artery. Sakamoto K, Murata T, Chuma H, *Hori M, Ozaki H. Arteriosclerosis, Thrombosis, and Vascular Biology. 25 327-333 2005.
Dexamethasone blocks hypoxia-induced endothelial dysfunction in organ-cultured pulmonary arteries. *Murata T, Hori M, Sakamoto K, Karaki H, Ozaki H. American Journal of Respiratory and Critical Care Medicine. 170 647-655 2004.
Chronic hypoxia impairs the interaction between eNOS and its regulatory proteins in rat pulmonary artery. *Murata T, Sato K, Hori M, Ozaki H, Hideaki H. Circulation. 106 210-211 2002.
Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension. Murata T, Sato K, Hori M, Ozaki H, Karaki H. The Journal of Biological Chemistry. 277 44085-44092 2002.
Chronic effect of doxorubicin on vascular endothelium assessed by organ culture study. Murata T, Yamawaki H, Yoshimoto R, Hori M, Sato K, Ozaki H, *Karaki H. Life Sciences. 69 2685-2695 2001.
Contribution of chloride channel activation to the elevated muscular tone of the pulmonary artery in monocrotaline-induced pulmonary hypertensive rats. Nakazawa H, Hori M, Murata T, Ozaki H, *Karaki H. Japanese Journal of Pharmacology. 86 310-315 2001.
Hypoxia impairs endothelium-dependent relaxation in organ cultured pulmonary artery. Murata T, Yamawaki H, Hori M, Sato K, Ozaki H, *Karaki H. European Journal of Pharmacology. 421 45-53 2001.
Chronic vascular toxicity of doxorubicin in an organ-cultured artery. Murata T, Yamawaki H, Hori M, Sato K, Ozaki H, *Karaki H. British Journal of Pharmacology. 132 1365-1373 2001.
NAKAMURA original
Molecular identification of ghrelin receptor (GHS-R1a) and its functional role in the gastrointestinal tract of the guinea-pig. *Kitazawa T, Nakamura T, Saeki A, Teraoka H, Hiraga T, Kaiya H. Peptide. 32(9) 1876-86 2011.Ghrelin stimulates gastric motility of the guinea pig through activation of a capsaicin-sensitive neural pathway: in vivo and in vitro functional studies. Nakamura T, Onaga T, *Kitazawa T. Neurogastroenterol Motil. 22(4) 446-52 2010.
M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice. *Kitazawa T, Asakawa K, Nakamura T, Teraoka H, Unno T, Komori S, Yamada M, Wess J. J Pharmacol Exp Ther. 330(2) 487-93 2009.
Excitatory and inhibitory 5-hydroxytryptamine (5-HT) receptors expressed in the isolated porcine uterine muscles. Nakamura T, *Kitazawa T, Cao J, Iwamoto T, Teraoka H, Kadota K, Taneike T. Eur J Pharmacol. 600(1-3) 123-9 2008.
Characterization of prostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle. Cao J, Nakamura T, Kitazawa T, Yamashiki N, Yamamoto T, *Taneike T. Prostaglandins Other Lipid Mediat. 86(1-4) 26-34 2008.
Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle. *Kitazawa T, Hirama R, Masunaga K, Nakamura T, Asakawa K, Cao J, Teraoka H, Unno T, Komori S, Yamada M, Wess J, Taneike T. Naunyn Schmiedebergs Arch Pharmacol. 377(4-6) 503-13 2008.
