助教 前田真吾(まえだしんご)

  • 〒113-8657 東京都文京区弥生1-1-1
    東京大学・大学院農学生命科学研究科・獣医臨床病理学研究室
    前田 真吾
    Tel: 03-5841-3096(7号館A棟203号室)
    Tel: 03-5841-5420(動物医療センター)
    Fax: 03-5841-3096
    E-mail: amaeda@mail.ecc.u-tokyo.ac.jp

    Shingo MAEDA, DVM, Ph.D. (Assistant professor)
    Laboratory of Veterinary Clinical Pathobiology,
    Department of Veterinary Medical Sciences,
    Graduate School of Agricultural and Life Sciences,
    The University of Tokyo,
    1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
    Tel: +81-3-5841-3096
    Fax: +81-3-5841-3096
    E-mail: amaeda@mail.ecc.u-tokyo.ac.jp

専門分野

  • 臨床病理学
  • 粘膜免疫学
  • 腫瘍学

主要な研究テーマ

  • 腫瘍組織への制御性T細胞浸潤機構の解明
  • 腫瘍組織における血管新生促進機構の解明
  • 慢性腸炎の病態解析
  • アレルギー性疾患および慢性腎臓病におけるプロテアーゼの役割解明

履歴

  • 1983年9月 兵庫県生まれ、静岡県育ち
  • 2009年3月 岐阜大学農学部獣医学科卒業
  • 2013年3月 東京大学大学院農学生命科学研究科獣医学専攻博士課程修了
  • 2013年4月 東京大学大学院農学生命科学研究科 獣医薬理学研究室 特任研究員
  • 2013年8月 東京大学大学院農学生命科学研究科 放射線動物科学研究室 特任助教
  • 2015年4月 東京大学大学院農学生命科学研究科 獣医臨床病理学研究室 特任助教
  • 2016年10月 同・助教  現在に至る

原著論文(英文:査読あり)

  1. Maeda S*, Tsuboi M, Sakai K, Ohno K, Fukushima K, Kanemoto H, Hiyoshi-Kanemoto S, Goto-Koshino Y, Chambers JK, Yonezawa T, Uchida K, Matsuki N. Endoscopic Cytology for the Diagnosis of Chronic Enteritis and Intestinal Lymphoma in Dogs. Veterinary Pathology. 2017; in press
  2. Kobayashi K, Horikami D, Omori K, Nakamura T, Yamazaki A, Maeda S, Murata T*. Thromboxane A2 exacerbates acute lung injury via promoting edema formation. Scientific Reports. 2016; 6:32109
  3. Murakami K, Maeda S, Yonezawa T, Matsuki N*. CC chemokine ligand 2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in canine idiopathic polyarthritis. Veterinary Immunology and Immunopathology. 2016;182: 52-58.
  4. Uchida M, Saeki K, Maeda S, Tamahara S, Yonezawa T*, Matsuki N. Apoptosis inhibitor of macrophage (AIM) reduces cell number in canine histiocytic sarcoma cell lines. Journal of Veterinary Medical Science. 2016;78(9): 1515-1520
  5. Murakami K, Maeda S, Yonezawa T, Matsuki N*. Synovial fluid matrix metalloproteinase-2 and -9 activities in dogs suffering from joint disorders. Journal of Veterinary Medical Science. 2016; 78(6): 1051-1054
  6. Maeda S, Ohno K*, Fujiwara-Igarashi A, Uchida K, Tsujimoto H. Changes in Foxp3-positive Treg number in the intestine of dogs with idiopathic inflammatory bowel disease and intestinal lymphoma. Veterinary Pathology. 2016; 53(1): 102-112
  7. Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T*. PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. Nature Communications. 2015; 6:7514
  8. Nakashima K, Hiyoshi S, Ohno K*, Uchida K, Goto-Koshino Y, Maeda S, Mizutani N, Takeuchi A,Tsujimoto H. Prognostic factors in dogs with protein-losing enteropathy. Veterinary Journal. 2015; 205(1):28-32.
  9. Hiyoshi S, Ohno K*, Uchida K, Goto-Koshino Y, Nakashima K, Fukushima K, Kanemoto H, Maeda S, Tsujimoto H. Association between lymphocyte antigen receptor gene rearrangements and histopathological evaluation in canine chronic enteropathy. Veterinary Immunology and Immunopathology. 2015; 165(3-4):138-144.
  10. Goto-Koshino Y*, Mochizuki H, Sato M, Nakashima K, Hiyoshi S, Fujiwara-Igarashi A, Maeda S, Nakamura K, Uchida K, Fujino Y, Ohno K, Tsujimoto H. Construction of a multicolor GeneScan analytical system to detect clonal rearrangements of immunoglobulin and T cell receptor genes in canine lymphoid tumors. Veterinary Immunology and Immunopathology. 2015; 165(1-2):81-87.
  11. Maeda S, Igarashi H, Ohno K*, Horigome A, Odamaki T, Tsujimoto H. Effect of Oral Administration of Metronidazole or Prednisolone on Fecal Microbiota in Dogs. PLoS One. 2014; 9(9): e107909.
  12. Maeda S, Ohno K*, Uchida K, Igarashi H, Goto-Koshino Y, Fujino Y, Tsujimoto H. Intestinal Protease-Activated Receptor-2 and Fecal Serine Protease Activity are Increased in Canine Inflammatory Bowel Disease and May Contribute to Intestinal Cytokine Expression. Journal of Veterinary Medical Science. 2014; 76(8): 1119-1127.
  13. Maeda S, Ohno K*, Fujiwara-Igarashi A, Tomiyasu H, Fujino Y, Tsujimoto H. Methylation of TNFRSF13B and TNFRSF13C in duodenal mucosa in canine inflammatory bowel disease and its association with decreased mucosal IgA expression. Veterinary Immunology and Immunopathology. 2014; 160(1-2): 97-106.
  14. Maeda S, Nakamura T, Murata T*. Tumor suppressor prostaglandin D2. Oncoscience. 2014; 1(6): 396-397.
  15. Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T*. Mast cell-derived PGD2 inhibits colitis and colitis-associated colon cancer in mice. Cancer Research. 2014; 74(11): 3011-3019.
  16. Igarashi H, Ohno K*, Maeda S, Kanemoto H, Fukushima K, Uchida K, Tsujimoto H. Expression profiling of pattern recognition receptors and selected cytokines in miniature dachshunds with inflammatory colorectal polyps. Veterinary Immunology and Immunopathology. 2014; 159(1-2): 1-10.
  17. Fujiwara-Igarashi A, Goto-Koshino Y, Sato M, Maeda S, Igarashi H, Takahashi M, Fujino Y, Tsujimoto H*. Prognostic significance of the expression levels of the p16, p15, and p14 genes in dogs with high-grade lymphoma. The Veterinary Journal. 2014; 199(2): 236-244.
  18. Kubota S, Ohno K*, Tsukamoto A, Maeda S, Murata Y, Nakashima K, Fukushima K, Uchida K, Fujino Y, Tsujimoto H. Value of the 13C-Urea Breath Test for Detection of Gastric Helicobacter spp. Infection in Dogs Undergoing Endoscopic Examination. Journal of Veterinary Medical Science. 2013; 75(8): 1049-1054.
  19. Fujiwara-Igarashi A, Goto-Koshino Y, Mochizuki H, Maeda S, Fujino Y, Ohno K, Tsujimoto H*. Simultaneous Inactivation of the p16, p15 and p14 Genes Encoding Cyclin-Dependent Kinase Inhibitors in Canine T-Lymphoid Tumor Cells. Journal of Veterinary Medical Science. 2013; 75: 733-42.
  20. Maeda S, Maeda S, Ohno K*, Kaji N, Hori M, Fujino Y, Tsujimoto H. Protease-activated receptor-2 induces proinflammatory cytokine and chemokine gene expression in canine keratinocytes. Veterinary Immunology and Immunopathology. 2013; 153: 17-25.
  21. Maeda S, Ohno K*, Uchida K, Nakashima K, Fukushima K, Tsukamoto A, Nakajima M, Fujino Y, Tsujimoto H. Decreased immunoglobulin A concentrations in feces, duodenum, and peripheral blood mononuclear cells of dogs with inflammatory bowel disease. Journal of Veterinary Internal Medicine. 2013; 27: 47-55.
  22. Maeda S, Fujino Y*, Tamamoto C, Suzuki S, Fujita A, Takahashi M, Ohno K, Uchida K, Tsujimoto H. Lymphangiomatosis of the systemic skin in an old dog. Journal of Veterinary Medical Science. 2013; 75: 187-190.
  23. Maeda S, Ohno K*, Nakamura K, Uchida K, Nakashima K, Fukushima K, Nakajima M, Goto-Koshino Y, Fujino Y, Tsujimoto H. Increased expression of fractalkine and its receptor CX3CR1 in canine inflammatory bowel disease and their possible role in recruitment of intraepithelial lymphocytes. Veterinary Immunology and Immunopathology. 2012; 148: 226-235.
  24. Maeda S, Ohno K*, Nakamura K, Uchida K, Nakashima K, Fukushima K, Tsukamoto A, Goto-Koshino Y, Fujino Y, Tsujimoto H. Mucosal imbalance of interleukin-1beta and interleukin-1 receptor antagonist in canine inflammatory bowel disease. The Veteryanry Journal. 2012; 194: 66-70.
  25. Tsukamoto A, Ohno K*, Maeda S, Nakashima K, Fukushima K, Fujino Y, Hori M, Tsujimoto H. Effect of mosapride on prednisolone-induced gastric mucosal injury and gastric-emptying disorder in dogs. Journal of Veterinary Medical Science. 2012; 74: 1103-1108.
  26. Maeda S, Ohno K*, Tsukamoto A, Nakashima K, Fukushima K, Goto-Koshino Y, Fujino Y, Tsujimoto H. Molecular cloning and expression analysis of the canine chemokine receptor CCR9. Veterinary Immunology and Immunopathology. 2012; 145: 534-539.
  27. Maeda S, Ohno K*, Nakashima K, Fukushima K, Tsukamoto A, Suzuki H, Fujiwara A, Goto-Koshino Y, Fujino Y, Tsujimoto H. Molecular cloning and characterization of canine fractalkine and its receptor CX3CR1. Veterinary Immunology and Immunopathology. 2012; 145: 100-109.
  28. Tsukamoto A, Ohno K*, Irie M, Ohmi A, Maeda S, Nakashima K, Fukushima K, Fujino Y, Uchida K, Tsujimoto H. A Case of Canine Multiple Inflammatory Colorectal Polyps Treated by Endoscopic Polypectomy and Argon Plasma Coagulation. Journal of Veterinary Medical Science. 2012; 74: 503-506.
  29. Tsukamoto A, Ohno K*, Maeda S, Nakashima K, Fukushima K, Fujino Y, Tsujimoto H. Prokinetic effect of the 5-HT4R agonist mosapride on canine gastric motility. Journal of Veterinary Medical Science. 2011; 73: 1635-1637.
  30. Tsukamoto A, Ohno K*, Tsukagoshi T, Maeda S, Nakashima K, Fukushima K, Fujino Y, Takeuchi A, Tsujimoto H. Ultrasonographic evaluation of vincristine-induced gastric hypomotility and the prokinetic effect of mosapride in dogs. Journal of Veterinary Internal Medicine. 2011; 25: 1461-1464.
  31. Tsukamoto A, Ohno K, Tsukagoshi T, Maeda S, Nakashima K, Fukushima K, Fujino Y, Tsujimoto H. Real-time ultrasonographic evaluation of canine gastric motility in the postprandial state. Journal of Veterinary Medical Science. 2011; 73: 1133-1138.
  32. Maeda S, Ohno K*, Nakamura K, Uchida K, Nakashima K, Fukushima K, Tsukamoto A, Goto-Koshino Y, Fujino Y, Tsujimoto H. Quantification of chemokine and chemokine receptor gene expression in duodenal mucosa of dogs with inflammatory bowel disease. Veterinary Immunology and Immunopathology. 2011; 144: 290-298.
  33. Shibata S, Maeda S*, Maeda S, Chimura N, Kondo N, Fukata T. Augmentation of CCL17 and CCL28 gene expression by TNF-alpha, IL-1beta, or IFN-gamma in cultured canine keratinocytes. Research in Veterinary Science. 2010; 88: 422-426.
  34. Shibata S, Maeda S*, Kondo N, Inoue A, Maeda S, Chimura N, Fukata T. Effect of recombinant canine interferon-gamma on granulocyte-macrophage colony-stimulating factor, transforming growth factor-beta and CC chemokine ligand 17 mRNA transcription in a canine keratinocyte cell line (CPEK). Veterinary Dermatology. 2010; 22: 24-30.
  35. Maeda S, Maeda S*, Shibata S, Chimura N, Fukata T. Molecular cloning of canine protease-activated receptor-2 and its expression in normal dog tissues and atopic skin lesions. Journal of Veterinary Medical Science. 2009; 71: 577-582.
  36. Maeda S, Maeda S*, Shibata S, Chimura N, Fukata T. House dust mite major allergen Der f 1 enhances proinflammatory cytokine and chemokine gene expression in a cell line of canine epidermal keratinocytes. Veterinary Immunology and Immunopathology. 2009; 131: 298-302.

商業誌記事(過去5年間)

  1. 前田真吾・大野耕一・中島 亘・福島健次郎・藤野泰人・辻本 元『イヌの炎症性腸疾患におけるフラクタルカインおよびその受容体CX3CR1 の関与』JVM 7月号、文永堂出版社、2012、pp. 557-560(執筆分)
  2. 前田真吾 『深遠なる腸管免疫1』Veterinary Immunology for Practitioners vol. 1、動物アレルギー検査株式会社、2016
  3. 前田真吾 『深遠なる腸管免疫2』Veterinary Immunology for Practitioners vol. 2、動物アレルギー検査株式会社、2016
  4. 前田真吾 『深遠なる腸管免疫3』Veterinary Immunology for Practitioners vol. 3、動物アレルギー検査株式会社、2016
  5. 前田真吾 『深遠なる腸管免疫4』Veterinary Immunology for Practitioners vol. 4、動物アレルギー検査株式会社、2017
  6. 前田真吾 『深遠なる腸管免疫5』Veterinary Immunology for Practitioners vol. 5、動物アレルギー検査株式会社、2017

所属学会・研究会

  • 所属学会・研究会
  • 日本獣医学会
  • 日本獣医臨床病理学会

競争的研究資金(過去5年間)

  1. 「トリプターゼ・PAR-2経路によるアナフィラキシー発症機構の解明」2015年度、科学研究費 研究活動スタート支援、代表
  2. 「肥満細胞トリプターゼ・PAR-2経路による血管新生促進機構の解明と癌治療への応用」2016~2019年度 科学研究費 若手研究 (A)、代表