東京大学 獣医内科学教室 本文へジャンプ
スタッフ紹介


教授 (Professor)

 辻本 元 (Hajime Tsujimoto, DVM, Ph.D)

 研究分野:
犬のリンパ腫の診断法および治療法の向上に関する研究
-微小残存病変
-薬剤耐性
-クローン性解析
-骨髄移植

 研究業績:

Ohmori, K., Masuda, K., DeBoer, D. J., Sakaguchi, M. and Tsujimoto, H.  Immunoblot analysis for IgE-reactive components of fetal calf serum in sera from dogs that developed allergic reactions after non-rabies vaccination.  Vet. Immunol. Immunopathol. 115:166-171 (2007).

 

Matsuura, S., Koto, H., Ide, K., Fujino, Y., Setoguchi-Mukai, A., Ohno, K. and Tsujimoto, H.  Induction of chemoresistance in a canine cultured cell line by retroviral transduction of the canine multidrug resistance 1 gene (mdr1).  Am. J. Vet. Res. 68:95-100 (2007).


Ohmori, K., Masuda, K., Kawarai, S., Yasuda, N., Sakaguchi, M., and Tsujimoto, H.  Identification of bovine serum albumin as an IgE-reactive beef component in a dog with food hypersensitivity against beef.  J. Vet. Med. Sci. 69:865-867 (2007).


Baba K, Mizukoshi F, Goto-Koshino Y, Setoguchi-Mukai A, Fujino Y, Ohno K, Tsujimoto H. Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines. Vet Microbiol. 2007 Mar 10;120(3-4):207-216.

 Kitamura, Y., Koto, H., Matsuura, S., Kawabata, T., Tsuchiya, H., Kusuhara, H., Tsujimoto, H. and Sugiyama, Y.  Modest effect of impaired P-glycoprotein on the plasma concentration of fexofenadine, quinidine, and loperamide following oral administration in collies.  Drug. Metab. Dispos. 36:807-810 (2008).

 

Baba, K., Goto-Koshino, Y., Mizukoshi, F., Setoguchi-Mukai, A., Fujino, Y., Ohno, K. and Tsujimoto, H.  Inhibition of the replication of feline immunodeficiency virus by lentiviral vector-mediated RNA interference in feline cells.  J. Vet. Med. Sci. 70:777-783 (2008).

Ohmori, K., Kawarai, S., Yasuda, N., Tanaka, A., Matsuda, H., Nishimura, R., Sasaki, N., Tsujimoto, H and Masuda, K. Identification of c-kit mutations-independent neoplastic cell proliferation of canine mast cells.  Vet. Immunol. Immunopathol. 126:43-53 (2008).

 

Takeuchi, Y., Matsuura, S., Fujino, Y., Nakajima, M., Takahashi, M., Nakashima, K., Sakai, Y., Uetsuka, K., Ohno, K., Nakayama, H. and Tsujimoto H.  Hypereosinophilic syndrome in two cats.  J. Vet. Med. Sci.  In press, (2008).

 

Ide, K., Matsuura, S., Fujino, Y., Ohno, K. and Tsujimoto, H.  Investigation of various methods for the cryopreservation of canine bone marrow-derived CD34+ cells.  J. Vet. Med. Sci.  In press, (2008). 

 

Hisasue, M., Nagashima, N., Nishigaki, K., Fukuzawa, I., Ura, S., Katae, H., Tsuchiya, R., Yamada, T., Hasegawa, A. and Tsujimoto, H.  Myelodysplastic syndrome and acute myeloid leukemia in cats infected with feline leukemia virus clone 33 containing a unique long terminal repeat.  Int. J. Cancer, In press (2008~2009).

 

Yamazaki, J., Baba, K., Goto-Koshino, Y., Setoguchi-Mukai, A., Fujino, Y., Ohno, K. and Tsujimoto, H.  Quantitative assessment of minimal residual disease (MRD) in canine lymphoma by using real-time polymerase chain reaction.  Vet. Immunol. Immunopathol.  126:321-331 (2008).

 

Ide, K., Goto-Koshino, Y., Momoi, Y., Fujino, Y., Ohno, K. and Tsujimoto, H.  Quantitative analysis of mRNA transcripts of Hox, SHH, PTCH, Wnt, and Fzd genes in canine hematopoietic progenitor cells and various in vitro colonies differentiated from the cells.  J. Vet. Med. Sci., In press (2009).

 

Mizukoshi, F., Baba, K., Goto-Koshino, Y., Setoguchi-Mukai, A., Fujino, Y., Ohno, K., Tamamura, H., Oishi, S., Fujii, N. and Tsujimoto, H.  Inhibitory effect of newly developed CXC-chemokine receptor antagonists on the infection with feline immunodeficiency virus.  J. Vet. Md. Sci., In press (2009).

 

Mizukoshi, F., Baba, K., Goto, Y., Setoguchi, A., Fujino, Y., Ohno, K., Oishi, S., Kodera, Y., Fujii, N. and Tsujimoto, H.  Antiviral activity of membrane fusion inhibitors that target gp40 of the feline immunodeficiency virus envelope protein.  Vet. Microbiol., In press (2009).

Mizukoshi F, Baba K, Horiuchi H, Goto-Koshino Y, Setoguchi-Mukai A, Fujino Y, Ohno K, Moore PF, Tsujimoto H. Characterization of monocyte-derived dendritic cells from cats infected with feline immunodeficiency virus. J Vet Med Sci. 2009 Jul;71(7):865-71.

Yamazaki J, Takahashi M, Setoguchi A, Fujino Y, Ohno K, Tsujimoto H. Monitoring of minimal residual disease (MRD) after multidrug chemotherapy and its correlation to outcome in dogs with lymphoma: a proof-of-concept pilot study. J Vet Intern Med. 2010 Jul-Aug;24(4):897-903.



准教授 (Associate Professor)

 大野 耕一 (Koichi Ohno, DVM, Ph.D)

 研究分野:
・犬の炎症性腸炎における病態解析に関する研究
・犬および猫の急性相蛋白の臨床応用に関する研究
・犬および猫の慢性肝疾患の新規診断法および病態解析に関する研究
・免疫介在性関節炎に関する臨床および免疫学的研究
・犬および猫の栄養アセスメント蛋白に関する研究

 研究業績:


Arata S, Ohmi A, Mizukoshi F, Baba K, Ohno K, Setoguchi A, Tsujimoto H. Urinary transforming growth factor-beta1 in feline chronic renal failure. J Vet Med Sci 67:1253-1255 (2005).

Ohno K, Konishi S, Kobayashi S, Nakashima K, Setoguchi A, Fujino Y, Nakayama H, Tsujimoto H. Prognostic factors associated with survival in dogs with lymphocytic-plasmacytic enteritis. J Vet Med Sci;68:929-933 (2006).

Ohno K, Yokoyama Y, Nakashima K, Setoguchi A, Fujino Y, Tsujimoto H. C-reactive protein concentration in canine idiopathic polyarthritis. J Vet Med Sci ;68:1275-1279 (2006).

Baba K, Mizukoshi F, Goto-Koshino Y, Setoguchi-Mukai A, Fujino Y, Ohno K, Tsujimoto H. Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines. Vet Microbiol;120:207-216 (2007).

Kobayashi S, Ohno K, Uetsuka K, Nakashima K, Setoguchi A, Fujino Y, Tsujimoto H. Measurement of intestinal mucosal permeability in dogs with lymphocytic-plasmacytic enteritis. J Vet Med Sci ;69:745-749 (2007).

Yamagishi C, Momoi Y, Kobayashi T, Ide K, Ohno K, Tsujimoto H, Iwasaki T. A retrospective study and gene analysis of canine sterile panniculitis. J Vet Med Sci ;69:915-924 (2007).

Nakamura M, Takahashi M, Ohno K, Koshino A, Nakashima K, Setoguchi A, Fujino Y, Tsujimoto H. C-reactive protein concentration in dogs with various diseases. J Vet Med Sci ;70:127-131 (2008)

Tamamoto T, Ohno K, Ohmi A, Seki I, Tsujimoto H. Time-course monitoring of serum amyloid A in a cat with pancreatitis. J Clin Pathol in press (2008).

Tamamoto T, Ohno K, Ohmi A, Goto-Koshino Y, Tsujimoto H. Verification of measuring feline serum amyloid A (SAA) concentration by human SAA turbidimetric immunoassay and its clinical application. J Vet Med Sci in press (2008).

Kanemoto H, Ohno K, Nakashima K, Takahashi M, Fujino Y, Tsujimoto H. Vascular and Kupffer Imaging of Canine Liver and Spleen Using the New Contrast Agent Sonazoid. J Vet Med Sci in press (2008).

Kanemoto H, Ohno K, Sakai M, Nakashima K, Takahashi M, Fujino Y, Tsujimoto H. Blood hyaluronic acid as a marker for canine cirrhosis. J Vet Med Sci. 2009 Sep;71(9):1251-4.


大野耕一 「内視鏡を用いた消化管の病変観察と生検法」 Surgeon 2005年Vol.9, No.3


大野耕一 「C反応性蛋白(CRP)に関する基礎知識」 SAMedicine 2006年Vol.8, No.5


大野耕一 「縫合糸反応性肉芽腫ー内科医の独り言」 InfoVets 2006年Vol.9, No.5

大野耕一 「「免疫介在性多発性関節炎」は内科疾患である!」  SAMedicine  2006年Vol.8, No.4

大野耕一 「肝疾患分野におけるキーワード」 MVM 2007年7月号

大野耕一 「炎症性腸疾患IBD 治療のエビデンス」 J-Vet   2007年8月号


大野耕一 「消化管・肝臓の生検手技」 SAMedicine 2007年Vol.9, No.5

大野耕一 「新しい超音波造影剤「Sonazoid」の獣医臨床への応用」 SAMedicine 2007年      Vol.9, No.5


大野耕一 「消化管エコー検査:基本的な診かた・考え方」 MVM 2008年3月号


大野耕一 「肝外胆道系疾患の臨床診断と内科的管理」 Surgeon 2008年Vol.12, No.1


大野耕一 「糞便検査の進め方と糞便の肉眼的性状 SAMedicine 2008年Vol.9, No.1




特任助教 (動物医療センター) (Project Assistant Professor)

 高橋 雅 (Masashi Takahashi, DVM)

 研究分野:

悪性リンパ腫、血液疾患における診断および治療

抗がん剤の臨床試験について


 研究業績:


Fukushima, K., Ohno, K., Koshino-Goto, Y., Uchida K., Nomura K., Takahashi M., Nakashima K., Fujino Y. and Tsujimoto, H. Sensitivity for the detection of a clonally rearranged antigen receptor gene in endoscopically obtained biopsy specimens from canine Alimentary lymphoma. J. Vet. Med. Sci. 71: 1673-1676 (2009)

Kanemoto, H., Ohno, K., Sakai, M., Nakashima, K., Takahashi, M., Fujino, Y. and Tsujimoto, H. Blood hyaluronic acid as a marker for canine cirrhosis  J. Vet. Med. Sci. 71 (9): 1251-1254 (2009).

Kanemoto H., Ohno, K., Nakashima, K., Takahashi, M., Fujino, Y. and Tsujimoto, H.  Vascular and kupffer imaging of canine liver and spleen using the new contrast agent sonazoid  J. Vet. Med. Sci. 70: 1265-1268 (2008)

Takeuchi, Y., Matsuura, S., Fujino, Y., Nakajima, M., Takahashi, M., Nakashima, K., Sakai, Y., Uetsuka, K., Ohno, K., Nakayama, H. and Tsujimoto, H.  Hypereosinophilic syndrome in two cats J. Vet. Med. Sci. 70: 1085-1089 (2008).

Nakamura M, Takahashi M, Ohno K, Koshino A, Nakashima K, Setoguchi A,Fujino Y, Tsujimoto H. C-reactive protein cencentration in dogs with various diseases.J Vet Med Sci. 2008 Feb;70(2): 127-31

 

Suzuki K, Wakabayashi H, Takahashi M, Fukushima K, Yabuki A, Endo Y.

A Possible treatment strategy and clinical factors to estimate the treatment response in Bebesia gibsoni infection. J Vet Med Sci . 2007 May; 69 (5): 563-568 .


Takahashi M, Une R, Fukushima K, Fujiki M, Misumi K, Miyoshi N, Endo Y, Ohishi A, Akuzawa M. Molecular cloning of canine nm23 cDNAs and their expression in normal and tumor tissues. J Vet Med Sci . 2005 Aug; 67 (8): 837-841 .
 

 [総説等]

高橋 雅 中村 正明(2006):さまざまな疾患におけるCRP濃度,SA medicine 85 22-26


特任助教 (動物医療センター) (Project Assistant Professor)

 福島 建次郎 (Kenjiro Fukushima, DVM)

 研究分野:
犬の好中球における活性酸素産生能と疾患の関連性の検討

 研究業績:


Fukushima, K.
, Okai, Y., Matsuura, S., Tsujimoto, H. and Endo, Y.  Molecular cloning of feline lung resistance-related protein (LRP) cDNA and its expression in a feline lymphoma cell line and adriamycin-resistant subline. J. Vet. Med. Sci. 68: 885-890 (2006)

Fukushima, K., Ohno, K., Koshino-Goto, Y., Uchida K., Nomura K., Takahashi M., Nakashima K., Fujino Y. and Tsujimoto, H. Sensitivity for the detection of a clonally rearranged antigen receptor gene in endoscopically obtained biopsy specimens from canine Alimentary lymphoma. J. Vet. Med. Sci. 71: 1673-1676 (2009)

中島亘、福島建次郎、岡部幹  ドキシサイクリンの経口投与による食道狭窄と診断した猫の1例 SA Medicine 10 (2): 49-54 (2008)
特任助教 (動物医療センター)(Project Assistant Professor)

 金本 英之 (Hideyuki Kanemoto, DVM, Ph.D)

 研究テーマ:
犬の肝疾患に対する新たな検査・診断ツールの開発

 研究業績: 

Kanemoto, H., Ohno, K., Nakashima, K., Takahashi, M., Fujino, Y. and Tsujimoto, H.  Vascular and kupffer imaging of canine liver and spleen using the new contrast agent sonazoid  J. Vet. Med. Sci. 70: 1265-1268 (2008)

Kanemoto, H., Ohno, K., Nakashima, K., Takahashi, M., Fujino, Y. Nishimura, R.and Tsujimoto, H. Characterization of canine focal liver lesions, with contrast-enhanced ultrasound using a novel contrast agent sonazoid  Vet. Radiol. Ultrasound 50: 188-194 (2009).

Kanemoto, H., Ohno, K., Sakai, M., Nakashima, K., Takahashi, M., Fujino, Y. and Tsujimoto, H. Blood hyaluronic acid as a marker for canine cirrhosis  J. Vet. Med. Sci. 71 (9): 1251-1254 (2009).

Sato, M., Goto-Koshino, Y., Kanemoto H., Mochizuki, H., Fujino, Y., Ohno, K. and Tsujimoto, H. Characterization of canine BCL-6 cDNA and detection systems for its protein expression. Vet. Immun. Immunopathol. 140(1-2), 166~169 (2010)

Sato, M., Kanemoto, H., Kagawa, Y., Kobayashi, T., Goto-Koshino, Y., Mochizuki, H., Takahashi, M., Fujino, Y., Ohno, K. and Tsujimoto, H. Evaluation of the prognostic significance of BCL6 gene expression in canine high-grade B-cell lymphoma. Vet. J. (E-publication on 1st February, 2011) (2011).

Goto-Koshino, Y., Ohno, K., Nakajima, M., Mochizuki, H., Kanemoto, H., and Tsujimoto, H. A rapid and simple method to obtain canine peripheral blood-derived macrophage. J. Vet. Med. Sci., 73(6), 773~778 (2011).

Osumi, T., Ohno, K., Kanemoto, H., Nakashima, K., Uchida, K., Karasawa, A., Fujino, Y. and Tsujimoto, H. A case of recovery from canine destructive cholangitis in a miniature dachshund. J. Vet. Med. Sci., 73(7), 937~939. (2011).

Kanemoto, H., Ohno, K., Sakai, M., Nakashima, K., Takahashi, M., Fujino, Y. and Tsujimoto, H. Expression of fibrosis-related genes in canine chronic hepatitis. Vet. Pathol., 48,839~845. (2011).

金本英之、大野耕一  新しい超音波造影剤「Sonazoid」の獣医臨床への応用 SA Medicine 10: 47-53 (2007)

金本英之、中島亘  NSAIDsの経口投与後に胃潰瘍を起こした犬の一例. SA Medicine, 54 (2008)

金本英之、大野耕一   治療シリーズ-私はこうしている-Vol.10「肝胆道系・膵外分泌疾患」肝細胞腫瘍、胆管細胞腫瘍, SA Medicine, 73 (2011)


特任准教授

 越野 (後藤) 裕子 (Yuko Goto-Koshino, DVM, Ph.D)

 研究分野:

 研究業績: