Generation of canine gallbladder cholangiocyte organoids from healthy and gallbladder mucocele patient dogs for functional analysis of anion channels
Nagao I, Tomiyasu H, Goto-Koshino Y, Nakase K, Tsuruta T, Namiki Y, Sato R, Takahashi Y, Hashimoto Y, Takahashi Y, Takahashi N, Chambers JK, Uchida K, Baba K, Ambrosini YM, Okuda M.
Vet J. 2025
Molecular Classification Based on the Gene Expression Profiles in Canine Histiocytic Sarcoma Cells
Sakuma H, Tomiyasu H, Tani A, Goto-Koshino Y, Bonkobara M, Okuda M.
Vet Comp Oncol. 2025
Comprehensive investigation of gene mutations in canine large cell gastrointestinal lymphoma
Matsumura N, Tsuruta T, Goto-Koshino Y, Mizukami K, Aoi T, Yamada R, Matsumoto Y, Nagao I, Sakamoto M, Nakagawa T, Fukuoka R, Ohmi A, Chambers JK, Uchida K, Momozawa Y, Tomiyasu H.
Front Vet Sci. 2025
Measurement and estimation of normal mitral annular size using computed tomography in 248 small-breed dogs
Shimano S, Yamamoto K, Goto-Koshino Y, Tomiyasu H, Mizuno T.
J Vet Cardiol. 2025
Malignant peripheral nerve sheath tumor in the vagus nerve causing upper gastrointestinal signs in a dog
Shitamori F, Nakagawa T, Takahashi N, Sakamoto M, Takahashi Y, Yamamoto K, Chambers JK, Uchida K, Tomiyasu H
J Vet Med Sci. 2025
≪2024年≫
Antitumor effects of inhibitors of ERK and Akt pathways in canine histiocytic sarcoma cell lines
H. Sakuma, H. Tomiyasu, A. Tani, Y. Goto-Koshino, H. Tani, K. Ohno, H. Tsujimoto, M. Bonkobara, M.Okuda
Vet J (2024) 308:106264
DOI: 10.1016/j.tvjl.2024.106264 PMID: 39505062
Comprehensive gene expression analysis in gallbladder mucosal epithelial cells of dogs with gallbladder mucocele
Investigation of the mutations in the genes involved in Janus kinase/signal transducer and activator of transcription pathway in canine large cell gastrointestinal lymphoma
Takumi TSURUTA, Naoki MATSUMURA, Keijiro MIZUKAMI,Yuko GOTO-KOSHINO, Tomomi AOI, Ryoko YAMADA, Itsuma NAGAO,Megumi SAKAMOTO, Taisuke NAKAGAWA, Ray FUKUOKA, Aki OHMI,James K CHAMBERS, Kazuyuki UCHIDA, Yukihide MOMOZAWA,Hirotaka TOMIYASU
J Vet Med Sci (2024) 86:1052-1055.
doi: 10.1292/jvms.24-0096 PMID: 39135232
Characterization of faecal microbiota and serum inflammatory markers in dogs diagnosed with chronic enteropathy or small-cell lymphoma: a pilot study.
Kaga C, Kakiyama S, Hokkyo A, Ogata Y, Shibata J, Nagahara T, Nakazawa M, Nakagawa T, Tsujimoto H, Chambers JK, Uchida K, Matsumoto S, Kobayashi T, Tomiyasu H, Mizusawa N
Sci Rep (2024) 14:19387.
DOI: 10.1038/s41598-024-69923-1 PMID: 39169196
Diagnostic challenge in veterinary pathology: Detection of BRAFV595E mutation in a dog with follicular cystitis and flat urothelial lesion with atypia.
Chambers JK, Takahashi N, Kato S, Hashimoto Y, Goto-Koshino Y, Uchida K.
Vet Pathol (2024) 61(3):335-338
DOI: 10.1177/03009858231217242 PMID: 38088189
Gene expression profiles associated with early relapse during first remission induction in canine multicentric high-grade B-cell lymphoma.
Toyoda H, Tani A, Goto-Koshino Y, Motegi T, Sakamoto M, Mochizuki T, Harada K, Kobayashi T, Setoguchi A, Shizuta Y, Mizuno T, Irie M, Nakamichi J, Tsujimoto H, Ohmi A, Fukuoka R, Nakamura Y, Tomiyasu H
J Vet Med Sci (2024) 86:18-27.
DOI: 10.1292/jvms.23-0269 PMID: 37952972
Efficacy and adverse events of L-Asparaginase administration as a first-line treatment for feline large-cell gastrointestinal lymphoma.
Inazumi H, Toyoda H, Shimano S, Sakuma H, Sakamoto M, Nakagawa T, Fukuoka R, Omi A, Chambers JK, Uchida K, Goto-Koshino Y, Tomiyasu H
J Vet Med Sci (2024) 86:727-736.
DOI: 10.1292/jvms.23-0453PMID: 38825481
Transcriptomic analysis of bone marrow specimens collected from Miniature Dachshunds diagnosed with non-neoplastic bone marrow disorders.
Tani, A, Nakase K, Tomiyasu H, Neo S, Ohmi A, Goto-Koshino Y, Ohno K, Tsujimoto H
Vet Med Sci (2024) 86:737-743
DOI: 10.1292/jvms.23-0371PMID: 38825482
≪2023年≫
MUC5AC and MUC5B expression in canine gallbladder mucocele epithelial cells
Nagao, I., Tsuji, K., Goto-Koshino, Y., Tsuboi, M., Chambers, J. K., Uchida, K., Kambayashi, S., Tomiyasu, H., Baba, K., & Okuda M.
J Vet Med Sci. 85, 1269-1276 (2023)
Retrospective study of feline tracheal mass lesions
Kanemoto, H., Fujiwara-Igarashi, A., Kobayashi, T., Harada, K., Ichimata, M., Kim, S., Hosoya, K., Tomiyasu, H., Ohmi, A., & Tsujimoto, H.
J Feline Med Surg. 25, 1098612X231164611 (2023)
Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma
Asada, H., Tani, A., Sakuma, H., Hirabayashi, M., Matsumoto, Y., Watanabe, K., Tsuboi, M., Yoshida, S., Harada, K., Uchikai, T., Goto-Koshino, Y., Chambers, J.K., Ishihara, G., Kobayashi, T., Irie, M., Uchida, K., Ohno, K., Bonkobara, M., Tsujimoto, H., & Tomiyasu, H.
Sci Rep. 13, 8512 (2023)
Polyoxazoline-conjugated porcine serum albumin as an artificial plasma expander for dogs
Okamoto, W., Usui, T., Hasegawa, M., Kobayashi, T., Fujisawa, J., Taguchi, K., Matsumoto, K., Kohno, M., Iwazaki, M., Shimano, S., Nagao, I., Toyoda, H., Matsumura, N., Tomiyasu, H., Tochinai, R., & Komatsu, T.
Sci Rep. 13, 9512 (2023)
Detection of domestic cat hepadnavirus by next-generation sequencing and epidemiological survey in Japan
Sakamoto, H., Ito, G., Goto-Koshino, Y., Sakamoto, M., Nishimura, R., & Momoi, Y.
J Vet Med Sci. 85, 642-646 (2023)
Prognostic value of increased intraepithelial lymphocytes and lymphocytic clonality in dogs with chronic enteropathy or small-cell lymphoma
Nakashima, K., Matsumoto, I., Goto-Koshino, Y., Hiyoshi-Kanemoto, S., Kojima, K., Chambers, J.K., Takeuchi, Y., Tsujimoto, H., Tomiyasu, H., & Uchida, K.
Vet J. 296-297 (2023)
Analysis of fecal microbial profiles in dogs with intestinal lymphangiectasia
Nagahara, T., Ohno, K., Nakagawa, T., Goto-Koshino, Y., Chambers, J.K., Uchida, K., Mizusawa, N., Kaga, C., Nagazawa, M., Tomiyasu, H., & Tsujimoto, H.
J Vet Med Sci. 85, 199-206 (2023)
≪2022年≫
Outcomes and prognostic factors in canine epitheliotropic and nonepitheliotropic cutaneous T-cell lymphomas.
Azuma K, Ohmi A, Goto-Koshino Y, Tomiyasu H, Ohno K, Chambers JK, Uchida K, Namba H, Nagata M, Nagamine E, Nibe K, Irie M, Tsujimoto H.
Vet Comp Oncol. 20 118-126 (2022)
Association between intestinal lymphangiectasia and expression of inducible nitric oxide synthase in dogs with lymphoplasmacytic enteritis.
Nagahara T, Ohno K, Nagao I, Nakagawa T, Goto-Koshino Y, Tsuboi M, Chambers JK, Uchida K, Tomiyasu H, Tsujimoto H.
J Vet Med Sci. 84 20-24 (2022)
Effects of proportions of carbohydrates and fats in diets on mucin concentration and bile composition in gallbladder of dogs.
Shikano R, Ohno K, Nagahara T, Nagao I, Toyoda H, Nakagawa T, Goto-Koshino Y, Chambers JK, Tomiyasu H, Tsujimoto H.
J Vet Med Sci. 84 1465-1468 (2022)
Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds.
Ohmi A, Tanaka M, Rinno J, Tsuboi M, Chambers JK, Uchida K, Goto-Koshino Y, Tomiyasu H, Ohno K, Tsujimoto H.
Vet Med Sci. Epub ahead of print. (2022)
Efficacy and adverse events of continuous l-asparaginase administration for canine large cell lymphoma of presumed gastrointestinal origin.
Nakagawa T, Kojima M, Ohno K, Chambers JK, Uchida K, Ohmi A, Goto-Koshino Y, Tomiyasu H, Tsujimoto H.
Vet Comp Oncol. 20 102-108 (2022)
Changes in gene expression profiles and cytokine secretions in peripheral monocytes by treatment with small extracellular vesicles derived from a canine lymphoma cell line.
Tani A, Tomiyasu H, Asada H, Lin CS, Goto-Koshino Y, Ohno K, Tsujimoto H.
J Vet Med Sci. 84 712-719 (2022)
Evaluation of the degree and distribution of lymphangiectasia in full-thickness canine small intestinal specimens diagnosed with lymphoplasmacytic enteritis and granulomatous lymphangitis.
Nagahara T, Ohno K, Nagao I, Nakagawa T, Goto-Koshino Y, Tsuboi M, Chambers JK, Uchida K, Tomiyasu H, Tsujimoto H.
J Vet Med Sci. 84 566-573 (2022)
Evaluation of the central lymphatic vessel size using non-contrast-enhanced magnetic resonance lymphography in dogs with intestinal lymphangiectasia,
Nagahara T, Ohno K, Nagao I, Nakagawa T, Yokoyama N, Yamamoto K, Fujiwara R, Goto-Koshino Y, Chambers JK, Uchida K, Momoi Y, Tomiyasu H, Tsujimoto H
Jpn J Vet Res. 70 57-63 (2022)
Analysis of fecal microbial profiles in dogs with intestinal lymphangiectasia.
Nagahara T, Ohno K, Nakagawa T, Goto-Koshino Y, Chambers JK, Uchida K, Mizusawa N, Kaga C, Nakazawa M, Tomiyasu H, Tsujimoto H
J Vet Med Sci. in Press (2022)
犬のアレルギー性皮膚炎に対する治療における飼い主満足度関連因子の探索
遠藤玲希央、大野耕一、後藤裕子、村上義孝、富安博隆
日本獣医師会雑誌、75 157-164 (2022)
Successful treatment of a lung abscess without surgical intervention in a cat
Nishi, R., Ohmi, A., Tsuboi, M., Yamamoto, K., & Tomiyasu, H.
JFMS Open Rep. 8, 20551169221086434 (2022)
≪2021年≫
Clinical and histopathological features and prognosis of gastrointestinal adenocarcinomas in Jack Russell Terriers.
Ohmi, A., Ohno, K., Chambers JK., Uchida, K., Nakagawa, T., Tomiyasu, H., Tsujimoto, H.
J Vet Med Sci. 83 167-173 (2021)
Construction and validation of a scoring system to predict resistance to chemotherapeutic drugs using gene expression profiles in canine lymphoma.
Tani, A., Saegusa, Y., Ogawa, K., Tomiyasu, H., Takeuchi, Y., Harada, K., Kobayashi, T., Setoguchi, A., Nakamichi, J., Mizuno, T., Irie, M., Tokita, M., Fujita, K., Suenaga, M., Motegi, T., Ohmi, A., Goto-Koshino, Y., Ohno, K., Tsujimoto, H.
Res Vet Sci. 137 208-216 (2021)
Efficacy of chemotherapy and palliative hypofractionated radiotherapy for cats with nasal lymphoma.
Nakazawa, M., Tomiyasu, H., Suzuki, K., Asada, H., Fujiwara-Igarashi, A., Goto-Koshino, Y., Ohmi, A., Ohno, K., Fujita, F., Tsujimoto, H.
Vet Med Sci. 83 456-460 (2021)
Changes in the coagulation parameters in dogs with protein-losing enteropathy between before and after treatment.
Nagahara T, Ohno K, Nagao I, Nakagawa T, Yokoyama N, Ohmi A, Goto-Koshino Y, Chambers JK, Uchida K, Tomiyasu H, Tsujimoto H.
J Vet Med Sci. 83 1295-1302. (2021)
≪2020年≫
Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders.
Tani, A., Tomiyasu, H., Ohmi, A., Ohno, K., Tsujimoto, H.
J Vet Med Sci. 82 771-778 (2020)
Variations in ATP7B in cats with primary copper-associated hepatopathy.
Asada, H.,Chambers, JK.,Kojima, M.,Goto-Koshino, Y., Nakagawa, T., Yokoyama, N.,Tsuboi, M., Uchida, K., Tsujimoto, H., Ohno, K.
J Feline Med. Surg. 22(8):753-759 (2020)
Measurement of the concentration of serum soluble interleukin-2 receptor alpha chain in dogs with lymphoma.
Mizutani, N., Goto-Koshino, Y., Kurata, K., Fujiwara-Igarashi, A., Sakaguchi, M., Asada, M., Ohno, K.,Tsujimoto, H.
Vet. Immunol. Immunopathol. 225:110054 (2020)
Evaluation of an automated point-of-care test system for measuring thrombin-antithrombin complex in dogs.
Kato, D., Takahashi, T., Yonezawa, T., Ohmi, A., Takeda, S., Nakagawa, T., Hosoda, S., Kanemoto, H., Fukushima, K., Ohno, K., Matsuki, N., Tsujimoto, H.
J. Vet. Emerg. Crit. Care (San Antonio). 30(1):102-106 (2020)
Comparison of the efficacy of cyclosporine and leflunomide in treating inflammatory colorectal polyps in miniature dachshunds.
Tani, A., Seno, T., Yokoyama, N., Nakagawa, T., Tomiyasu, H., Goto-Koshino, Y., Tsujimoto, H., Ohno, K.
J. Vet. Med. Sci. 9;82(4):437-440 (2020)
Treatment with rivaroxaban and monitoring of coagulation profiles in two dogs with venous thromboembolism.
Uchida, M., Ohmi, A., Fujiwara, R., Fukushima, K., Doi, A., Azuma, K., Tsujimoto, H.
J. Vet. Med. Sci. 24;82(9):1271-1276 (2020)
≪2019年≫
Evaluation of visceral fat mass in dogs by computed tomography.
Nagao, I., Ohno, K., Nagahara, T., Yokoyama, N., Nakagawa, T., Fujiwara, R., Yamamoto, K., Goto-Koshino, Y., Tomiyasu, H., Tsujimoto, H.
J. Vet. Med. Sci. 81: 1552-1557 (2019)
Variations in ATP7B in cats with primary copper-associated hepatopathy.
Asada, H., Chambers, J.K., Kojima, M., Goto-Koshino, Y., Nakagawa, T., Yokoyama, N., Tsuboi, M., Uchida, K., Tsujimoto, H., Ohno, K.
J. Feline Med. Surg. doi: 10.1177/1098612X19884763 (2019)
Effect of a two-base insertion mutation of the TP53 gene on expression of p53 protein in canine histiocytic sarcoma cells.
Asada, H., Tomiyasu, H., Goto-Koshino, Y., Ohno, K., Tsujimoto, H.
J. Vet. Res. 80: 680-688 (2019)
Development of canine X-chromosome inactivation pattern analysis for the detection of cell clonality by incorporating the examination of the SLIT and NTRK-like family member 4 (SLITRK4) gene.
Tomita, A., Mochizuki, H., Tsuboi, M., Ogura, I., Igarashi, H., Goto-Koshino, Y., Takahashi, M., Ohmi, A., Tomiyasu, H., Ohno, K., Nakagawa, T., Uchida, K., Nishimura, R., Tsujimoto, H.
Res. Vet. Sci. 125: 170-175 (2019)
Comprehensive analysis of miRNA and protein profiles within exosomes derived from canine lymphoid tumour cell lines.
Asada, H., Tomiyasu, H., Uchikai, T., Ishihara, G., Goto-Koshino, Y., Ohno, K., Tsujimoto, H.
PLoS One 2019:14 e0208567
Hepatic copper accumulation in a young cat with familial variations in the ATP7B gene.
Asada, H., Kojima, M., Nagahara, T., Goto-Koshino, Y., Chambers, J.K., Nakagawa, T., Yokoyama, N., Uchida, K., Tsujimoto, H. and Ohno, K.
J. Vet. Intern. Med. 33:874-878 (2019)
Clinical significance of the two-base insertion mutation in the TP53 gene in canine histiocytic sarcoma.
Asada, H., Tomiyasu, H., Okada, K., Chambers, J.K., Goto-Koshino, Y., Uchida, K., Kagawa, Y., Ohno, K. and Tsujimoto. H.
Res. Vet. Sci. 124:57-60 (2019)
The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma.
Asada, H., Ichii, O., Tomiyasu, H., Uchida, K., Chambers, J.K., Goto-Koshino, Y., Ohno, K., Kon, Y. and Tsujimoto, H.
J. Vet. Med. Sci. 81:353-356 (2019)
≪2018年≫
Clinical and clinicopathological characteristics of acute lymphoblastic leukaemia in six cats.
Tomiyasu, H., Doi, A., Chambers, J.K., Goto‐Koshino, Y., Ohmi, A., Ohno, K. and Tsujimoto, H.
J. Small Anim. Prac.59:742-746 (2018)
Influence of the expression of CD44 variant isoforms on the prognosis in canine multicentric high-grade B-cell lymphoma.
Motegi, T., Tomiyasu, H., Goto-Koshino, Y., Takahashi, M., Hiyoshi-Kanemoto, S., Fujino, Y., Ohno, K. and Tsujimoto, H.
J. Vet. Res., Epub ahead of print (2018)
IgA antibodies against gliadin and tissue transglutaminase in dogs with chronic enteritis and intestinal T-cell lymphoma.
Matsumoto, I., Uchida, K., Nakashima, K., Hiyoshi, S., Chambers, J.K., Tsujimoto, H. and Nakayama, H.
Vet. Pathol. 55:98-107 (2018)
Prognostic significance of hypermethylation of death-associated protein kinase (DAPK) gene CpG island in dogs with high-grade B-cell lymphoma.
Sato, M., Mochizuki, H., Goto-Koshino, Y., Fujiwara-Igarashi, A., Takahashi, M., Ohno, K. and Tsujimoto, H.
Comp. Oncol., Epub ahead of print (2018)
Pathological features of intestinal T-cell lymphoma in Shiba dogs in Japan.
Matsumoto I., Uchida, K., Nakashima, K., Goto-Koshino, Y., Chambers, J., Tsujimoto, H. and Nakayama, H.
Comp. Oncol., Epub ahead of print (2018)
Multiple acquired portosystemic shunts secondary to primary hypoplasia of the portal vein in a cat.
Sugimoto, S., Maeda, S., Tsuboi, M., Saeki, K., Chambers, J.K., Yonezawa, T., Fukushima, K., Fujiwara, R., Uchida, K., Tsujimoto, H., Matsuki, N. and Ohno, K.
Vet. Med. Sci., Epub ahead of print (2018)
Evaluation of an automated point-of-care test system for measuring thrombin-antithrombin complex in dogs.
Kato, D., Takahashi, M., Yonezawa, T., Ohmi, A., Takeda, S., Nakagawa, T., Hosoda, S., Ohno, K., Kanemoto, H., Fukushima, K., Matsuki, N. and Tsujimoto, H.
Vet. Emerg. Crit. Care, Epub ahead of print (2018)
≪2017年≫
Detection of monoclonality in intestinal lymphoma with polymerase chain reaction for antigen receptor gene rearrangement analysis to differentiate from enteritis in dogs.
Ohmura, S., Leipig, M., Schöpper, I., Hergt, F., Weber, K., Rütgen, B.C., Tsujimoto, H., Hermanns, W. and Hirschberger, J.
Comp. Oncol. 15:194-207 (2017)
Plasma matrix metalloproteinase-9 activity in cats with lymphoma.
Tamamoto, T., Ohno, K., Takahashi, M., Fukushima, K., Kanemoto, H., Fujino, Y., and Tsujimoto, H.
Comp. Oncol. 15:1-5 (2017)
Melting curve analysis in canine lymphoma by calculating maximum fluorescence decrease.
Schöpper, I., Ohmura, S., Rütgen, B., Tsujimoto, H., Weber, K. and Hirschberger, J.
Comp. Oncol. 15:563-575 (2017)
The first report of the ante-morten diagnosis of Ollulanus tricuspis infection in two dogs.
Kato, D., Oishi, M., Ohno, K., Nakashima, K., Wada, A., Fukumoto, S., Morita, T., Imai, S., Tsuboi, M., Chambers, J.K., Uchida, K. and Tsujimoto, H.
Vet. Med. Sci. 77:1499-1502 (2017)
Assessment of severity and changes in C-reactive protein concentration and various biomarkers in dogs with pancreatitis.
Sato, T., Tamamoto, T., Oishi, M., Ohno, K., Kanemoto, H., Fukushima, K., Goto-Koshino, Y., Takahashi, M. and Tsujimoto, H.
Vet. Med. Sci. 79:35-40 (2017)
Analysis of serum corticosteroid-induced alkaline phosphatase isoenzyme in dogs with hepatobiliary diseases.
Kojima, K., Ohno K., Kanemoto, H., Goto-Koshino, Y., Fukushima, K. and Tsujimoto, H.
Small Anim. Prac. 58:257-262 (2017)
Long-term management of a dog with idiopathic megaesophagus and recurrent aspiration pneumonia by use of an indwelling esophagostomy tube for suction of esophageal content and esophagogastric tube feeding.
Kanemoto, Y., Fukushima, K., Kanemoto, H., Ohno, K. and Tsujimoto, H.
Vet. Med. Sci. 79:188-191 (2017)
Primary cerebellar lymphoma with Hodgkin lymphoma-like morphology in a cat.
Yoshino, Y., Chambers, J.K., Nakamori, T., Goto-Koshino, Y., Nishigaki, K., Tsujimoto, H., Matsuki, N., Nakayama, H. and Uchida, K.
Vet. Diag. Invest. 29:707-710 (2017)
Genetic and epigenetic aberrations of p16 in feline primary neoplastic diseases and tumor cell lines of lymphoid and non-lymphoid origins.
Mochizuki, H., Fujiwara-Igarashi, A., Sato, M., Goto-Koshino, Y., Ohno, K. and Tsujimoto, H.
J. 219:27-33 (2017).
Bile acid composition of gallbladder contents in dogs with gallbladder mucocele and biliary sludge.
Kakimoto,T., Kanemoto, H., Fukushima, K., Ohno, K. and Tsujimoto, H.
J. Vet. Res. 78:223-229 (2017)
Epidemiological study on feline gastric Helicobacter in Japan.
Kubota-Aizawa, S., Ohno, K., Kanemoto, H., Nakashima, K., Fukushima, K., Uchida, K., Chambers, J., Goto-Koshino, Y., Mimuro, H., Watanabe, T., Sekizaki, T. and Tsujimoto, H.
J. Vet. Med. Sci. 79:876-880 (2017)
Hypoxia-activated prodrug TH-302 decreased survival rate of canine lymphoma cells under hypoxic condition.
Yamazaki, H., Lai, Y.-C., Tateno, M., Setoguchi, A., Goto-Koshino, Y., Endo, Y., Nakaichi, M., Tsujimoto, H. and Miura, N.
PLoS One 12:e0177305 (2017)
Effects of toceranib phosphate (Palladia) monotherapy on multidrug resistant lymphoma on dogs.
Yamazaki, H., Miura, N., Lai Y.-C., Takahashi, M., Goto-Koshino, Y., Momoi, Y., Nakaichi, M., Tsujimoto, H., Setoguchi, A. and Endo,
Vet. Med. Sci. 79:1225-1229 (2017)
Characterization of a novel canine T-cell line established from a dog with cutaneous T-cell lymphoma.
Hara, K., Iio, A., Asahina, R., Takahashi, M., Mori, T., Nishida, H., Kamishina, H., Sakai, H., Kitoh, K., Mizuno, T., Tsujimoto, H. and Maeda, S.
Dermatol. Sci. 88:254-256 (2017)
Significance of clonal rearrangements of lymphocyte antigen receptor genes on the prognosis of chronic enteropathy in 22 Shiba dogs.
Ohmi, A., Ohno, K., Uchida, K., Goto-Koshino, Y., Tomiyasu, H., Kanemoto, H., Fikushima, K. and Tsujimoto, H.
Vet. Med. Sci. 79:1578-1584 (2017)
Molecular epidemiological study of gammaherpesvirus in domestic cats in Japan.
Tateno, M., Takahashi, M., Miyake, E., Sakata, Y., Nishigaki, K., Tsujimoto, H. and Endo, Y.
Vet. Med. Sci. 79:1735-1740 (2017)
A 2-base insertion in exon 5 is a common mutation of the TP53 gene in dogs with histiocytic sarcoma.
Asada, H., Tsuboi, M., Chambers, J.K., Uchida K., Tomiyasu, H., Goto-Koshino, Y., Ohno, K. and Tsujimoto, H.
Vet. Med. Sci. 79:1721-1726 (2017)
Analysis of fecal short chain fatty acid concentration in miniature dachshunds with inflammatory colorectal polyps.
Igarashi, H., Ohno, K., Matsuki, N., Fujiwara-Igarashi, A., Kanemoto, H., Fukushima, K., Uchida, K. and Tsujimoto, H.
Vet. Med. Sci. 79:1727-1734 (2017)
Intrahepatic cholelithiasis in dogs and cats: A case series.
Kanemoto, H., Fukushima, K., Tsujimoto, H. and Ohno, K.
Vet. J. 58:971-973 (2017)
Adenocarcinoma of Barrett’s esophagus in a dog.
Chambers, J.K., Saito, T., Fukushima, K., Kakuta, S., Ohno, K., Tsujimoto, H., Nakayama, H. and Uchida, K.
Toxicol. Pathol. 30:239-243 (2017)
Molecular survey of Bartonella henselae and Bartonella clarridgeiae in pet cats across Japan by species-specific nested-PCR.
Sato, S., Kabeya, H., Negishi, A., Tsujimoto, H., Nishigaki, K., Endo, Y. and Maruyama, S.
Infect. 145:2694-2700 (2017)
Epidemiological study of gastric Helicobacter spp. in dogs with gastrointestinal disease in Japan and diversity of Helicobactor heilmannii sensu stricto.
Kubota-Aizawa, S., Ohno, K., Fukushima, K., Kanemoto, H., Nakashima, K., Uchida, K., Chambers, J.K., Goto-Koshino, Y., Watanabe, T., Sekizaki, T., Mimuro, H. and Tsujimoto, H.
J., Epub ahead of print (2017)
Comprehensive analysis of gene expression profiles reveals candidates of chemotherapy resistant factors in canine lymphoma.
Suenaga, M., Tomiyasu, H., Watanabe, M., Ogawa, K., Motegi, T., Goto-Koshino, Y., Ohno, K., Sugano, S., Skorupski, K.A. and Tsujimoto, H.
Effect of a high-fat-high-cholesterol diet on gallbladder bile acid composition and gallbladder motility in dogs.
Kakimoto, T., Kanemoto, H., Fukushima, K., Ohno, K. and Tsujimoto, H.
J. Vet. Res. 78:1406-1413 (2017)
Effects of serum amyloid A on matrix metalloproteinase-9 production in feline lymphoma-derived cell lines.
Tamamoto, T., Goto-Koshino, Y., Ohno, K. and Tsujimoto, H.
Immunol. Immunopathol. 187:10-13 (2017)
≪2016年≫
Evaluation of CD25-positive cells in relation to the subtypes and prognoses in various lymphoid tumours in dogs.
Mizutani, N., Goto-Koshino, Y., Tsuboi, M., Kagawa, Y., Ohno, K., Uchida, K. and Tsujimoto, H.
Immunol. Immunopathol. 173:39-43 (2016)
Clinical and histopathological evaluation of 16 dogs with T-zone lymphoma.
Mizutani, N., Goto-Koshino, Y., Uchida, K., Takahashi, M. and Tsujimoto, H.
Vet. Med. Sci. 78:1237-1244 (2016)
Fecal dysbiosis in miniature dachshunds with inflammatory colorectal polyps.
Igarashi, H., Ohno, K., Horigome, A., Fujiwara-Igarashi, A., Kanemoto, H., Fukushima, K., Odamaki, T. and Tsujimoto, H.
Vet. Sci. 105:41-46 (2016)
Intranuclear inclusions in a dog with B-cell leukemia.
Kato, D., Takahashi, M., Harada, T., Tsuboi, M., Uchida, K., Fukushima, K., Kanemoto, H., Fujino, Y., Ohno, K., Nakayama, H. and Tsujimoto, H.
Clin. Pathol. 45:579-583 (2016)
Comprehensive genomic characterization of five canine lymphoid tumor cell lines.
Roode, S.C., Rotroff, D., Richards, K.L., Moore, P., Motsinger-Reif, A., Okamura, Y., Mizuno, T., Tsujimoto, H., Suter, S.E. and Breen, M.
BMC Vet. Res. 12:207 (2016)
Pathological features of colorectal inflammatory polyps in miniature dachshunds.
Uchida, E., Chambers, J.K., Nakashima, K., Saito, T., Ohno, K., Tsujimoto, H., Nakayama, H. and Uchida, K.
Pathol. 53:9833-839 (2016)
Efficacy of leflunomide for treatment of refractory inflammatory colorectal polyps in 15 Miniature Dachshunds.
Fukushima, K., Eguchi, N., Ohno, K., Kanemoto, H., Takahashi, M., Igarashi, H., Ohmi, A., Nakashima, K. and Tsujimoto, H.
Vet. Med. Sci. 78:265-269 (2016)
Mutation of p53 gene and its correlation with the clinical outcome in dogs with lymphoma.
Koshino, A., Goto-Koshino, Y., Setoguchi, A., Ohno, K. and Tsujimoto, H.
Vet. Intern. Med. 30:223-229 (2016)
Characterization of triple-phase computed tomography in dogs with pancreatic insulinoma.
Fukushima, K., Fujiwara, R., Yamamoto, K., Kanemoto, H., Ohno, K., Takahashi, M., Nakashima, K., Fujino, Y., Tsuboi, M., Uchida, K., Matsuki, N., Nishimura, R. and Tsujimoto, H.
Vet. Med. Sci. 77:1549-1553 (2016)
Changes in Foxp3-positive regulatory T cell number in the intestine of dogs with idiopathic inflammatory bowel disease and intestinal lymphoma.
Maeda, S., Ohno, K., Fujiwara-Igarashi, A., Uchida, K. and Tsujimoto, H.
Pathol. 53:102-112 (2016)
Minimal residual disease in canine lymphoma: An objective marker to assess tumor cell burden in remission.
Sato, M., Yamazaki, J., Goto-Koshino, Y., Setoguchi, A., Takahashi, M., Baba, K., Fujino, Y., Ohno, K. and Tsujimoto, H.
J. 215:38-42 (2016)
Detection of circulating tumor cells using GeneScan analysis for antigen receptor gene rearrangements in canine lymphoma patients.
Hiyoshi-Kanemoto, S., Goto-Koshino, Y., Fukushima, K., Takahashi, M., Kanemoto, H., Uchida, K., Fujino, Y., Ohno, K. and Tsujimoto, H.
Vet. Med. Sci. 78:877-881 (2016)
Novel feline leukemia virus interference group based on the env gene.
Miyake, A., Watanabe, S., Hiratsuka, T., Ito, J., Ngo, M.H., Makundi, I., Kawasaki, J., Endo, Y., Tsujimoto, H. and Nishigaki, K.
Virol. 90:4832-4837 (2016)
Changes in the small intestine of a cat associated with barium sulphate following contrast radiography.
Igarashi, H., Oishi, M., Ohno, K., Tsuboi, M., Irie, N., Uchida, K. and Tsujimoto, H.
Comp. Pathol. 154:235-238 (2016)
Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior.
Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20.
Weiskopf, K., Anderson, K.L., Ito, D., Schnorr, P.J., Tomiyasu, H., Ring, A.M., Bloink, K., Efe, J., Rue, S., Lowery, D., Barkal, A., Prohaska, S., McKenna, K.M., Cornax, I., O'Brien, T.D., O'Sullivan, M.G., Weissman, I.L., Modiano, J.F.
Cancer Immunol Res. 2016;4(12) 1072-1087.
≪2015年≫
World Small Animal Veterinary Association (WSAVA) Vaccination Guidelines Group (VGG). Recommendation on vaccination for Asian small animal practitioners: a report of the WSAVA Vaccination Guidelines Group.
Day M.J., Karkare, U., Schultz, R.D., Squires, R. and Tsujimoto H
Small Anim. Prac. 56:77-95 (2015)
Functional analysis of pattern recognition receptors in miniature dachshunds with inflammatory colorectal polyps.
Igarashi, H., Ohno, K., Fujiwara-Igarashi, A., Kanemoto, H., Fukushima, K., Goto-Koshino, Y., Uchida, K. and Tsujimoto, H.
J. Vet. Med. Sci. 77:439-447 (2015)
Evaluation of the drug sensitivity and expression of 16 drug resistance-related genes in canine histiocytic sarcoma cell lines.
Asada, H., Tomiyasu, H., Goto-Koshino, Y., Fujino, Y., Ohno, K. and Tsujimoto, H.
J. Vet. Med. Sci. 77:677-684 (2015)
Inflammatory colorectal polyps in miniature Dachshunds frequently develop ventrally in the colorectal mucosa.
Igarashi, H., Ohno, K., Fujiwara-Igarashi, A., Kanemoto, H., Fukushima, K., Uchida, K. and Tsujimoto, H.
Vet. J. 203:256-258 (2015)
Construction of a multicolor GeneScan analytical system to detect clonal rearrangements of immunoglobulin and T cell receptor genes in canine lymphoid tumors.
Goto-Koshino, Y., Mochizuki, H., Sato, M., Nakashima, K., Hiyoshi, S., Fujiwara-Igarashi, A., Maeda, S., Nakamura, K., Uchida, K., Fujino, Y., Ohno, K. and Tsujimoto, H.
Immunol. Immunipathol. 165:81-87 (2015)
急性巨核芽球性白血病の犬の１例
舛方祐子、林聡恵、秋吉秀保、大橋文人、玉本智枝、望月浩之、辻本元、安田和雄
日本獣医師会雑誌 68:182-187 (2015)
Genetic diversity in the feline leukemia virus gag gene.
Kawamura, M., Watanabe, S., Odahara, Y., Nakagawa, S., Endo, Y., Tsujimoto, H. and Nishigaki, K.
Virus Res. 204:74-81 (2015)
Association between lymphocyte antigen receptor gene rearrangements and histopathological evaluation in canine chronic enteropathy.
Hiyoshi, S., Ohno, K., Uchida, K., Goto-Koshino, Y., Nakashima, K., Fukushima, K., Kanemoto, H., Maeda, S. and Tsujimoto, H.
Immunol. Immunopathol. 165:138-144 (2015)
Polymorphisms of nucleotide-binding oligomerization domain 2 (NOD2) gene in miniature dachshunds with inflammatory colorectal polyps.
Igarashi, H., Ohno, K., Uchida, E., Fujiwara-Igarashi, A., Kanemoto, H., Fukushima, K., Uchida, K. and Tsujimoto, H.
Immunol. Immunopathol. 164:160-169 (2015)
Measurement of feline lipase activity using a dry-chemistry assay with a triolein substrate and comparison with pancreas-specific lipase (Spec fPLTM).
Oishi, M., Ohno, K., Sato, T., Tamamoto, T., Kanemoto, H., Fukushima, K. and Tsujimoto, H.
Vet. Med. Sci. 77:1495-1497 (2015)
Prognostic factors in dogs with protein-losing enteropathy.
Nakashima, K., Hiyoshi, S., Ohno, K., Uchida, K., Goto-Koshino, Y., Mizutani, N., Takeuchi, A. and Tsujimoto, H.
J. 205:28-32 (2015)
Comparative aspects of molecular mechanisms of drug resistance through ABC transporters and other related molecules in canine lymphoma.
Tomiyasu, H. and Tsujimoto, H.
Sci. 2:185-205 (2015)
Expression profile of circulating serum microRNAs in dogs with lymphoma.
Fujiwara-Igarashi, A., Igarashi, H., Mizutani, N., Goto-Koshino, Y., Takahashi, M., Ohno, K. and Tsujimoto, H.
J. 205:317-321 (2015)
Aberrant RB-E2F Transcriptional Regulation Defines Molecular Phenotypes of Osteosarcoma.
Scott, M.C., Sarver, A.L., Tomiyasu, H., Cornax, I, VamEtten, J., Varshney, J., O’Sullivan, M.G., Subramanian, S. and Modiano, J.F.
J. Biol. Chem. 2015;290(47) 28070-28083.
≪2014年≫
The regulation of the expression of ABCG2 gene through mitogen-activated protein kinase pathways in canine lymphohoid tumor cell lines.
Tomiyasu, H., Goto-Koshino, Y., Fujino, Y., Ohno, K. and Tsujimoto, H.
Vet. Med. Sci. 76:237-242 (2014)
Prognostic significance of the expression levels of the p16, p15, and p14 genes in dogs with high-grade lymphoma.
Fujiwara-Igarashi, A., Goto-Koshino, Y., Sato, M., Maeda, S., Igarashi, H., Takahashi, M., Fujino, Y., Ohno, K. and Tsujimoto, H.
J. 199:236-244 (2014)
Epigenetic regulation of the ABCB1 gene in drug-sensitive and drug-resistant lymphoid tumor cell lines obtained from canine patients.
Tomiyasu, H., Goto-Koshino Y., Fujino, Y., Ohno, K. and Tsujimoto, H.
J. 199:103-109 (2014)
The association between gall bladder mucoceles and hyperlipidemia in dogs: A retrospective case control study.
Kutsunai, M., Kanemoto, H., Fukushima, K., Fujino, Y. and Ohno, K.
J. 199:76-79 (2014)
Notch2 transduction by feline leukemia virus in a naturally infected cat.
Watanabe, S., Ito, J., Baba, T., Ochi, H., Anai, Y., Hisasue, M., Tsujimoto, H. and Nishigaki, K.
J. Vet. Med. Sci. 76:553-557 (2014)
Computed tomographic morphology and clinical features of extrahepatic portosystemic shunts in 172 dogs in Japan.
Fukushima, K., Kanemoto, H., Ohno. K., Takahashi, M., Fujiwara, R., Nishimura, R. and Tsujimoto, H.
J. 199:376-381 (2014)
Plasma transferrin concentration as a nutritional marker in malnourished dogs with nutritional treatment.
Nakajima, M., Ohno, K., Goto-Koshino, Y., Fujino, Y and Tsujimoto, H.
J. Vet. Med. Sci. 76:539-543 (2014)
Clinical characteristics and prognostic factors in dogs with histiocytic sarcomas in Japan.
Takahashi, M., Tomiyasu, H., Hotta, E., Asada, H., Fukushima, K., Kanemoto, H., Fujino, Y., Uchida, K., Nakayama, H. and Tsujimoto, H.
J. Vet. Med. Sci. 76:661-666 (2014)
Prognostic analyses on anatomical and morphological classification of feline lymphoma.
Sato, H., Fujino, Y., Chino, J., Takahashi, M., Fukushima, K., Goto-Koshino, Y., Uchida, K., Ohno, K. and Tsujimoto, H.
J. Vet. Med. Sci. 76:807-811 (2014)
Phase I dose-escalation study of nimustine in tumor-bearing dogs.
Takahashi, M., Goto-Koshino, Y., Fukushima, K., Kanemoto, H., Nakashima, K., Fujino, Y., Ohno, K., Endo, Y., and Tsujimoto, H.
J. Vet. Med. Sci. 76:895-899 (2014)
Demonstration of the cell clonality in canine hematopoietic tumors by X-chromosome inactivation pattern analysis.
Mochizuki, H., Goto-Koshino, Y., Takahashi, M., Fujino, Y., Ohno, K. and Tsujimoto, H.
Pathol. 52:61-69 (2014)
Expression profiling of pattern recognition receptors and selected cytokines in miniature dachshunds with inflammatory colorectal polyps.
Igarashi, H., Ohno, K., Maeda, S., Kanemoto, H., Fukushima, K., Uchida, K. and Tsujimoto, H.
Immunol. Immunopathol. 159:1-10 (2014)
Differential expression of CD45 isoforms in canine leukocytes.
Goto-Koshino, Y., Tomiyasu, H., Suzuki, H., Tamamoto, T., Mizutani, N., Fujino, Y., Ohno, K. and Tsujimoto, H.
Immunol. Immunopathol. 160:118-122 (2014)
Antitumour effect and modulation of expression of ABCB1 gene by perifosine in canine lymphoid tumour cell lines.
Tomiyasu, H., Goto-Koshino, Y., Fujino, Y., Ohno, K. and Tsujimoto, H.
J. 201:83-90 (2014)
Inhibition of p16 tumor suppressor gene expression via promoter hypermethylation in canine lymphoid tumor cells.
Fujiwara-Igarashi, A., Goto-Koshino, Y., Mochizuki, H., Sato, M., Fujino, Y., Ohno, K. and Tsujimoto, H.
Vet. Sci. 97:60-63 (2014)
Methylation of TNFRSF13B and TNFRSF13C in duodenal mucosa in canine inflammatory bowel disease and its association with decreased mucosal IgA expression.
Maeda, S., Ohno, K., Fujiwara-Igarashi, A., Tomiyasu, H., Fujino, Y. and Tsujimoto, H.
Immunol. Immunopathol. 160:97-106 (2014)
Intestinal protease-activated receptor-2 and fecal serine protease activity are increased in canine inflammatory bowel disease and may contribute to intestinal cytokine expression.
Maeda, S., Ohno, K., Uchida, K., Nakashima, K., Fukushima, K., Igarashi, H., Goto-Koshino, Y., Fujino, Y. and Tsujimoto, H.
J. Vet. Med. Sci. 76:1119-1127 (2014)
Serum amyloid A promotes invasion of feline mammary carcinoma cells.
Tamamoto, T., Ohno, K., Goto-Koshino, Y. and Tsujimoto, H.
J. Vet. Med. Sci. 76:1183-1188 (2014)
Evaluation of DNA methylation profiles of the CpG island of the ABCB1 gene in dogs with lymphoma.
Tomiyasu, H., Fujiwara-Igarashi, A., Goto-Koshino, Y., Fujino, Y., Ohno, K. and Tsujimoto, H.
J. Vet. Res. 75:835-841 (2014)
Hypermethylation of the death-associated protein kinase CpG island in canine B-cell lymphoid tumors.
Sato, M., Mochizuki, H., Goto-Koshino, Y., Fujiwara-Igarashi, A., Takahashi, M., Fujino, Y., Ohno, K. and Tsujimoto, H.
Immunol. Immunopathol. 161:222-231 (2014)
Effect of oral administration of metronidazole or prednisolone on fecal microbiota in dogs.
Igarashi, H., Maeda, S., Ohno, K., Horigome, A., Odamaki, T. and Tsujimoto, H.
