東京大学大学院農学生命科学研究科　獣医病理学研究室

主な研究業績
Recent publications

2018
Wang H, Hirabayashi M, Chambers JK, Uchida K, Nakayama H. Immunohistochemical studies on meningoencephalitis in feline infectious peritonitis (FIP). J Vet Med Sci. in press

Uneyama M, Chambers JK, Miyama K, Miwa Y, Uchida K, Nakayama H. A histopathological study on adrenal cysts in ferrets. J Toxicol Pathol. in press

Kishimoto TE, Chambers JK, Miyama K, Son NV, Kok MK, Uneyama M, Miwa Y, Nakayama H, Uchida K. Neuromastoma of the hard palate mucosa in an Australian green tree frog (Litoria caerulea). J Vet Med Sci. in press

Takaichi Y, Ano Y, Chambers JK, Uchida K, Takashima A, Nakayama H. Deposition of phosphorylated α-synuclein in the rTg4510 mouse model of tauopathy. J Neuropathol Exp Neurol. 2018;77(10):920-928.

Sumi A, Chambers JK, Doi M, Kudo T, Omachi T, Uchida K. Clinical features and outcomes of Merkel cell carcinoma in 20 cats. Vet Comp Oncol. in press

Matsumoto I, Nakashima K, Goto-Koshino Y, Chambers JK, Tsujimoto H, Nakayama H, Uchida K. Immunohistochemical profiling of canine intestinal T-cell lymphomas. Vet Pathol. in press

Matsumoto I, Uchida K, Nakashima K, Goto-Koshino Y, Chambers JK, Tsujimoto H, Nakayama H. Pathological features of intestinal T-cell lymphoma in Shiba dogs in Japan. Vet Comp Oncol. in press

Kok MK, Chambers JK, Ong SM, Nakayama H, Uchida K. Hierarchical cluster analysis of cytokeratins and stem cell expression profiles of canine cutaneous epithelial tumors. Vet Pathol. in press

Caswell JL, Bassel LL, Rothenburger JL, Grone A, Sargeant JM, Beck AP, Ekman S, Gibson-Corley KN, Kuiken T, LaDouceur EEB, Meyerholz DK, Origgi FC, Posthaus H, Priestnall SL, Ressel L, Sharkey L, Teixeira LBC, Uchida K, Ward JM, Webster JD, Yamate J. Observational study design in veterinary pathology, part 1: study design. Vet Pathol. 2018;55(5):607-621.

SaitoT, Chambers JK, Nakashima K, Uchida E, Ohno K, Tsujimoto H, Uchida K, Nakayama H. Histopathological features of colorectal adnoma and adnocarcinoma dveloping within inflamatory polyps in miniature dachshunds. Vet Pathol. 2018;55(5):654-662.

Kishimoto TE, Uchida K, Thongtharb A, Shibato T, Chambers JK, Nibe K, Kagawa Y, Nakayama H. Expression of oligodendrocyte precursor cell markers in canine oligodendrogliomas. Vet Pathol. 2018;55(5):634-644.

Matsumoto I, Chambers JK, Nibe K, Kinoshita R, Nishimura R, Nakayama H, Uchida K. Histopathologic and immunohistochemistry findings in feline renal cell carcinoma, Vet Pathol. 2018;55(5):663-672.

Son NV, Chambers JK, Shiga T, Kishimoto T, Kikuhara S, Saeki K, Fujiwara R, Tsuboi M, Nishimura R, Uchida K, Nakayama H. Sarcomatoid mesothelioma of tunica vaginalis testis in the right scrotum of a dog. J Vet Med Sci. 2018;80(7):1125-1128.

Chambers JK, Shiga T, Takimoto H, Dohata A, Miwa Y, Nakayama H, Uchida K. Proliferative lesions of the endometrium of 50 four-toed hedgehogs (Atelerix albiventris). Vet Pathol. 2018;55(4):562-571.

Chambers JK, Thongtharb A, Shiga T, Azakami D, Saito M, Sato M, Morozumi M, Nakayama H, Uchida K. Accumulation of laforin and other related proteins in canine Lafora disease with EPM2B repeat expansion. Vet Pathol. 2018;55(4):543-551.

Shiga T, Okuno S, Uchida K, Chambers JK, Nakayama H. Electrophysiological and histopathological findings of muscular disease suspected as myotonic dystrophy in a Shiba dog. J Vet Med Sci. 2018;80(3):480-484.

Kok MK, Chambers JK, Ushio N, Miwa Y, Nakayama H, Ucida K. Amyloid-producing odontoameloblastoma in a black tailed prairie dog (Cynomys ludovicianus). J Comp Pathol. 2018;159:26-30.

Tei M, Uchida K, Chambers JK, Watanabe K, Tamamoto T, Ohno K, Nakayama H. Variation of amino acid sequences of serum amyloid A (SAA) and immunohistochemical analysis of amyloid A (AA) in Japanese domestic cats. J Vet Med Sci. 2018;80(1):164-172.

Matsumoto I, Uchida K, Nakashima K, Hiyoshi S, Chambers JK, Tsujimoto H, Nakayama H. IgA antibodies against gliadin and tissue transglutaminase in dogas with chronic enteritis and intestinal T-cell lymphom. Vet Pathol. 2018;55(1):98-107.

２０１７
Dong J, Zhu W, Yamashita N, Chambers JK, Uchida K, Kuwano M, Haga T. Isolation of equine papillomavirus type 1 from racing horse in Japan. J Vet Med Sci. 2017;79(12):1957-1959.

Matsumoto I, Uchida K, Chambers JK, Nibe K, Hamasu T, Nakayama H. Hodgkin's-like lymphoma in a ferret (Mustela putorius furo). J Vet Med Sci. 2017;79(10):1660-1663.

Kubota-Aizawa S, Ohno K, Fukushima K, Kanemoto H, Nakashima K, Uchida K, Chambers JK, Goto-Koshino Y, Watanabe T, Sekizaki T, Mimuro H, Tsujimoto H. Epidemiological study of gastric Helicobacter spp. in dogs with gastrointestinal disease in Japan and diversity of Helicobacter heilmannii sensu stricto. Vet J. 2017;225:56-62.

Chambers JK, Saito T, Fukushima K, Kakuta S, Nakayama J, Ohno K, Tsujimoto H, Nakayama H, Uchida K. Adenocarcinoma of Barrett’s esophagus in a dog. J Toxicol Pathol. 2017;30(3):239-243.

Kok MK, Chambers JK, Ushio N, Watamori A, Miwa Y, Nakayama H, Uchida K. Histopathological and immunohistochemical study on rabbit trichoblastoma. J Comp Pathol. 2017;157(2-3):126-135.

Shiga T, Uchida K, Chambers JK, Nakayama H. Immunohistochemical analysis of canine and feline muscle disorders using formalin-fixed, paraffin-embedded tissues. J Vet Diagn Invest. 2017;29(6):805-813.

Kok MK, Chambers JK, Dohata A, Uchida K, Nishimura R, Nakayama H. Desmoplastic tricholemmoma in a dog. J Vet Med Sci. 2017;79(6):984-987.

Matsumoto I, Chambers JK, Miwa Y, Nakayama H, Uchida K. Anaplastic large T-cell lymphoma in three black-tailed prairie dogs (Cynomys ludovicianus). J Vet Med Sci. 2017;79(6):979-983.

Yoshino Y, Chambers JK, Nakamori T, Goto-Koshino Y, Nishigaki K, Tsujimoto H, Matsuki N, Nakayama H, Uchida K. Primary cerebellar lymphoma with Hodgkin lymphoma-like morphology in a cat. J Vet Diagn Invest. 2017;29(5):707-710.

Kubota-Aizawa S, Ohno K, Kanemoto H, Nakashima K, Fukushima K, Uchida K, Chambers JK, Goto-Koshino Y, Mimuro H, Watanabe T, Sekizaki T, Tsujimoto H. Epidemiological study on feline gastric Helicobacter spp. in Japan. J Vet Med Sci. 2017;79(5):876-880.

Thongtharb A, Uchida K, Chambers JK, Nakayama H. Variations in histiocytic differentiation of cell lines from canine cerebral and articular histiocytic sarcomas. Vet Pathol. 2017;54(3):395-404.

Watanabe KI, Chambers JK, Uchida K, Nibe K, Ushio N, Horiuchi N, Kobayashi Y, Nakayama H. A cutaneous mixed tumor in a dog. J Vet Med Sci. 2017;79(3):670-673.

Tsuboi M, Watanabe M, Nibe K, Yoshimi N, Kato A, Sakaguchi M, Yamato O, Tanaka M, Kuwamura M, Kushida K, Ishikura T, Harada T, Chambers JK, Sugano S, Uchida K, Nakayama H. Identification of the PLA2G6 c.1579G>A missense mutation in papillon dog neuroaxonal dystrophy using whole exome sequencing analysis. PLoS One. 2017;12(1):e0169002.

Watanabe K, Uchida K, Chambers JK, Ushio N, Nakayama H. Deposition, clearance, and reinduction of amyloid A amyloid in interleukin 1 receptor antagonist knockout mice. Vet Pathol. 2017;54(1):99-110.

Ano Y, Dohata A, Taniguchi Y, Hoshi A, Uchida K, Takashima A, Nakayama H. Iso-α-acids, Bitter Components of Beer, Prevent Inflammation and Cognitive ecline Induced in a Mouse Model of Alzheimer's Disease. J Biol Chem. 2017;292(9):3720-3728.

２０１６
Youssef SA, Capucchio MT, Rofina JE, Chambers JK, Uchida K, Nakayama H, Head E. Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal odels of Human Neurodegenerative Diseases. Vet Pathol. 2016;53(2):327-48.

Ide T, Moriyama A, Uchida K, Chambers JK, Okazaki T, Kobayashi K, Nakatsuji S, Matsumoto M. Neuroblastoma at the trigeminal nerve in a cynomolgus monkey (Macaca fascicularis). J Toxicol Pathol. 2016;29(3):191-4.

Kobayashi R, Chambers JK, Yoshida K, Nakamura T, Yasuno K, Uchida K, Kamiie J, Shirota K. Spontaneous lipoprotein glomerulopathy-like nephropathy in a squirrel (Sciurus vulgaris). J Zoo Wildl Med. 2016;47(2):663-6.

Uchida K, Park E, Tsuboi M, Chambers JK, Nakayama H. Pathological and mmunological features of canine necrotising meningoencephalitis and ranulomatous meningoencephalitis. Vet J. 2016;213:72-7.

Murakami S, Endoh M, Kobayashi T, Takenaka-Uema A, Chambers JK, Uchida K, Nishihara M, Hause B, Horimoto T. Influenza D virus infection in herd of cattle, Japan. Emerg Infect Dis. 2016;22(8):1517-9.

Chambers JK, Nakamori T, Kishimoto TE, Nakata M, Miwa Y, Nakayama H, Uchida K. Lachrymal gland basal cell adenocarcinoma in a ferret (Mustela putorius furo). J Comp Pathol. 2016;155(2-3):259-62.

Ushio N, Chambers JK, Watanabe K, Kishimoto TE, Li JY, Nakayama H, Uchida K. Abdominal hamartoma with pancreatic and hepatic differentiation in a sow. J Vet Med Sci. 2016;78(8):1373-5.

Thongtharb A, Uchida K, Chambers JK, Miwa Y, Murata Y, Nakayama H. Histological and immunohistochemical features of histiocytic sarcoma in four domestic ferrets (Mustela putorius furo). J Vet Diagn Invest. 2016;28(2):165-70.

Morimoto A, Omachi S, Osada Y, Chambers JK, Uchida K, Sanjoba C, Matsumoto Y, Goto Y. Hemophagocytosis in experimental visceral leishmaniasis by Leishmania donovani. PLoS Negl Trop Dis. 2016;10(3):e0004505.

Ozawa M, Chambers JK, Uchida K, Nakayama H. The Relation between canine cognitive dysfunction and age-related brain lesions. J Vet Med Sci. 2016;78(6):997-1006.

Uchida E, Chambers JK, Nakashima K, Saito T, Ohno K, Tsujimoto H, Nakayama H, Uchida K. Pathologic features of colorectal inflammatory polyps in Miniature Dachshunds. Vet Pathol. 2016;53(4):833-9.

Chambers JK, Yoshino Y, Fujiwara R, Nishimura R, Nakayama H, Uchida K. Thymic carcinoma with cartilage formation in a dog. J Comp Pathol. 2016;154(1):38-41.

Thongtharb A, Uchida K, Chambers JK, Kagawa Y, Nakayama H. Histological and immunohistochemical studies on primary intracranial canine histiocytic sarcomas. J Vet Med Sci. 2016;78(4):593-9.

Wada M, Hasegawa D, Hamamoto Y, Asai A, Shouji A, Chambers J, Uchida K, Fujita M. A canine case with cystic meningioma showing miraculous reduction of the cystic lesion. J Vet Med Sci. 2016;78(1):101-104.

Itoh T, Kojimoto A, Kushima K, Uchida K, Chambers JK, Shii H. Obstructive pyogranuomatous laryngitis in a dog treated with permanent tracheostomy. Jpn Vet Anesth Surg. 2016;47(1):1-5.

２０１５
He XJ, Uchida K, Megumi C, Tsuge N, Nakayama H. Dietary curcumin upplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) eurotoxicity in C57BL mice. J Toxicol Pathol. 2015;28(4):197-206.

Chambers JK, Tokuda T, Uchida K, Ishii R, Tatebe H, Takahashi E, Tomiyama T, Une Y, Nakayama H. The domestic cat as a natural animal model of Alzheimer's disease. Acta Neuropathol Commun. 2015;3:78.

Murata Y, Uchida K, Shioda C, Uema A, Bangphoomi N, Chambers JK, Akashi H, Nakayama H. Histopathological Studies on the neuropathogenicity of the Iriki and OBE-1 strains of Akabane virus in BALB/cAJcl Mice. J Comp Pathol. 2015;153(2-3):140-9.

Ushio N, Watanabe K, Chambers JK, Shibato T, Nakayama H, Uchida K. Sarcocystis calchasi encephalitis in a rock pigeon. J Vet Med Sci. 2015;77(11):1523-6.

Kato D, Oishi M, Ohno K, Nakashima K, Wada A, Morita T, Imai S, Tsuboi M, Chambers JK, Uchida K, Tsujimoto H. The first report of the ante-mortem diagnosis of Ollulanus tricuspis infection in two dogs. J Vet Med Sci. 2015;77(11):1499-502.

Murata Y, Chambers JK, Uchida K, Nakashima K, Hanafusa Y, Ikezawa M, Sugita T, Nakayama H. Mycotic aneurysm caused by Graphium species in a dog. J Vet Med Sci. 2015;77(10):1285-8.

Ogawa M, Uchida K, Yamato O, Mizukami K, Chambers JK, Nakayama H. Expression of autophagy-related proteins in the spinal cord of Pembroke Welsh Corgi dogs with canine degenerative myelopathy. Vet Pathol. 2015;52(6):1099-107.

Kanemoto H, Morikawa R, Chambers JK, Kasahara K, Hanafusa Y, Uchida K, Ohno K, Nakayama H. Common variable immune deficiency in a Pomeranian with Pneumocystis carinii pneumonia. J Vet Med Sci. 2015;77(6):715-9.

Dohata A, Chambers JK, Uchida K, Nakazono S, Kinoshita Y, Nibe K, Nakayama H. Clinical and pathologic study of feline Merkel cell carcinoma with immunohistochemical characterization of normal and neoplastic Merkel cells. Vet Pathol. 2015;52(6):1012-8.

Thongtharb A, Chambers JK, Uchida K, Watanabe K, Takahashi A, Mochizuki M, Nishimura R, Nakayama H. Lymphangiosarcoma with systemic metastases in a Japanese domestic cat. J Vet Med Sci. 2015;77(3):371-4.

Watanabe K, Uchida K, Chambers JK, Tei M, Shoji A, Ushio N, Nakayama H. Experimental transmission of AA amyloidosis by injecting the AA amyloid protein into interleukin-1 receptor antagonist knockout (IL-1raKO) mice. Vet Pathol. 2015;52(3):505-12.

Hirose N, Uchida K, Matsunaga S, Chambers JK, Nakayama H. Expression of cell adhesion molecules in canine choroid plexus tumors. J Vet Med Sci. 2015;77(2):255-9.

Nishi A, Itoh T, Uchida K, Chambers J, Shii H. Bilateral rostral mandibulectomy for treatment of a rapidly-growing amyloid-producing odontogenic tumor in a Shih-tzu dog. Jpn J Vet Anesth Surg. 2015;46(4):73-76.

Itoh T, Nishi A, Uchida K, Chambers J, Shii H. Resolution of megaesophagus after excision of a nasopharyngeal polyp in an 8-month-old cat. Jpn J Vet Anesth Surg. 2015;46(4):77-79.

Suzuki S, Uchida K, Harada T, Nibe K, Yamashita M, Ono K, Nakayama H. The origin and role of autophagy in the formation of cytoplasmic granules in canine lingual granular cell tumors. Vet Pathol. 2015;52(3):456-64.

Ano Y, Ozawa M, Kutsukake T, Sugiyama S, Uchida K, Yoshida A, Nakayama H. Preventive effects of a fermented dairy product against Alzheimer's disease and identification of a novel oleamide with enhanced microglial phagocytosis and anti-inflammatory activity. PLoS One. 2015 Mar 11;10(3):e0118512.

Itoh T, Nishi A, Chambers J, Uchida K, Shii H. Clinical features, pathological findings, andtreatment results of 29 cases of canine subcutaneous soft tissue sarcomas. Journal of Veterinary Medicine. 2015;68(10):757-762.

２０１４
Imura K, Chambers JK, Uchida K, Nomura S, Suzuki S, Nakayama H, Miwa Y. Herpes simplex virus type 1 infection in two pet marmosets in Japan. J Vet Med Sci. 2014;76(12):1667-70.

Tanaka Y, Chambers JK, Matsuwaki T, Yamanouchi K, Nishihara M. Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice. Acta Neuropathol Commun. 2014;2:78.

Ogawa M, Uchida K, Isobe K, Saito M, Harada T, Chambers JK, Nakayama H. Globoid cell leukodystrophy (Krabbe’s disease) in a Japanese domestic cat. Neuropathology. 2014;34(2):190-6.

Takahashi E, Kuribayashi H, Chambers JK, Imamura E, Une Y. Senile plaques and cerebral amyloid angiopathy in an aged California sea lion (Zalophus californianus). Amyloid. 2014;21(3):211-5.

Hirose N, Uchida K, Kanemoto H, Ohno K, Chambers JK, Nakayama H. A retrospective histopathological survey on canine and feline liver diseases at the University of Tokyo between 2006 and 2012. J Vet Med Sci. 2014;76(7):1015-20.

Chambers JK, Uchida K, Ise K, Nakayama H. Cystic rete ovarii and uterine tube adenoma in a rabbit. J Vet Med Sci. 2014;76(6):909-12.

Chambers JK, Uchida K, Murata Y, Watanabe K, Ise K, Miwa Y, Nakayama H. Cystic rete testis with testicular dysplasia in a rabbit. J Vet Med Sci. 2014;76(5):751-5.

Zhu W, Dong J, Uchida K, Watanabe K, Nakayama H, Goto Y, Haga T. Bovine papillomavirus type 10 with a deletion associated with a lingual papilloma in a cow. Vet J. 2014;199(2):303-5.

Harada T, Ogawa Y, Eguchi M, Shi F, Sato M, Uchida K, Nakayama H, Shimoji Y. Phosphorylcholine and SpaA, a choline-binding protein, are involved in the adherence of Erysipelothrix rhusiopathiae to porcine endothelial cells, but this adherence is not mediated by the PAF receptor. Vet Microbiol. 2014;172(1-2):216-22.

Park ES, Uchida K, Nakayama H. Establishment of a rat model for canine necrotizing meningoencephalitis (NME). Vet Pathol. 2014;51(6):1151-64.