研究業績 Publication

2023年度

1. Furuta, H.; Sheng, Y.; Takahashi, A.; Nagano, R.; Kataoka, N.; Perks, C.M.; Barker, R.; Hakuno, F.; Takahashi, S.-I.

   The IGF-Independent Role of IRS-2 in the Secretion of MMP-9 Enhances the Growth of Prostate Carcinoma Cell Line PC3.
   Int. J. Mol. Sci. 2023, 24, 15065. doi: 10.3390/ijms242015065.

   >URL

日本語著書および総説など

1. Kataoka N.

   The Nuclear Cap-Binding Complex, a multitasking binding partner of RNA polymerase II transcripts.
   J Biochem. 2023 Oct 13:mvad081. doi: 10.1093/jb/mvad081.

   >PubMed

2022年度

1. Oshizuki S, Matsumoto E, Tanaka S, Kataoka N.* (2022)(*Corresponding author)

   Mutations equivalent to Drosophila mago nashi mutants imply reduction of Magoh protein incorporation into exon junction complex.
   Genes Cells. 27(7), 505–511. doi: 10.1111/gtc.12941.

   >PubMed

2. Shinriki S, Hirayama M, Nagamachi A, Yokoyama A, Kawamura T, Kanai A, Kawai H, Iwakiri J, Liu R, Maeshiro M, Tungalag S, Tasaki M, Ueda M, Tomizawa K, Kataoka N, Ideue T, Suzuki Y, Asai K, Tani T, Inaba T, Matsui H.

   DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells.
   Leukemia. 2022 Oct 14. doi: 10.1038/s41375-022-01708-9.

   >PubMed

3. Nishitani K, Hayakawa K, Minatomoto M, Tanaka K, Ogawa H, Kojima H, Tanaka S.

   N-Oleoyldopamine promotes the differentiation of mouse trophoblast stem cells into parietal trophoblast giant cells.
   Biochem Biophys Res Commun. 2022 Oct 28;636(Pt 1):205-212. doi: 10.1016/j.bbrc.2022.10.085.

   >PubMed

4. Nishitani K, Hayakawa K, Tanaka S.

   Epidermal growth factor represses differentiation of mouse trophoblast stem cells into spongiotrophoblast cells via epidermal growth factor receptor.
   Biochem Biophys Res Commun. 2023 May 21;657:100-107. doi: 10.1016/j.bbrc.2023.03.059

   >URL

日本語著書および総説など

1. 片岡直行

   特集：mRNAスプライシング制御の最前線と創薬への応用
   骨髄異形成症候群 (MDS) における異常スプライシング機構
   生化学第94巻第6号, pp. 797-805 (2022)

2021年度

1. Goda, Y., Yamanaka, D., Nishi, H., Masuda, M., Kamei, H., Kumano, M., Ito, K., Katsumata, M., Yamanouchi, K., Kataoka, N., Hakuno, F., Takahashi, SI. (2021)

   Dietary lysine restriction induces lipid accumulation in skeletal muscle through an increase in serum threonine levels in rats
   Journal of Biological Chemistry, 297(4):101179. doi: 10.1016/j.jbc.2021.101179

   >PubMed

2. Fukushima S, Nishi H, Kumano M, Yamanaka D, Kataoka N, Hakuno F, Takahashi SI.

   A novel amino acid signaling process governs glucose-6-phosphatase transcription.
   iScience. 2021 Jun 24;24(7):102778. doi: 10.1016/j.isci.2021.102778.

   >PubMed

3. Hayakawa K. Tanaka S.

   Oocyte-specific linker histone H1foo interacts with Esrrb to induce chromatin decondensation at specific gene loci
   BBRC 561:165-171 (2021) doi: 10.1016/j.bbrc.2021.05.033

   >PubMed

4. Nakura T, Ozoe A, Narita Y, Matsuo M, Hakuno F, Kataoka N*, Takahashi SI*. (*Corresponding authors)

   Rbfox2 mediates exon 11 inclusion in insulin receptor pre-mRNA splicing in hepatoma cells.
   Biochimie. 2021 May 19:S0300-9084(21)00125-5. doi: 10.1016/j.biochi.2021.05.007.

   >PubMed

日本語著書および総説など

1. Kataoka, N.* and Cho, W.C. (2021) (*Corresponding author)

   Editorial: Interplay Between RNA Processing Machinery and Epigenetic Regulation in Gene Expression.
   Frontiers in Genetics, 12:799874. doi: 10.3389/fgene.2021.799874

   >PubMed

2. Zhang, W., Kataoka, N. and Guan, X. (2021)

   Editorial: Non-Coding RNAs in Breast Cancer.
   Frontiers in Oncology, 11:789798. doi: 10.3389/fonc.2021.789798

   >PubMed

3. Kataoka N*, Matsumoto E, Masaki S. (*Corresponding author)

   Mechanistic Insights of Aberrant Splicing with Splicing Factor Mutations Found in Myelodysplastic Syndromes.
   Int J Mol Sci. 2021 Jul 21;22(15):7789. doi: 10.3390/ijms22157789.

   >PubMed

2020年度

1. Shuai SUN, Shota YANO, Momo O NAKANISHI, Michiko HIROSE, Kazuhiko NAKABAYASHI, Kenichiro HATA, Atsuo OGURA, Satoshi TANAKA (2021)

   Maintenance of mouse trophoblast stem cells in KSR-based medium allows conventional 3D culture
   Journal of Reproduction and Development 2021 Mar 20.doi: 10.1262/jrd.2020-119.

   >PubMed

2. Muraoka S, Fukumura K, Hayashi M, Kataoka N, Mayeda A, Kaida D. (2020)

   Rbm38 Reduces the Transcription Elongation Defect of the SMEK2 Gene Caused by Splicing Deficiency.
   International Journal of Molecular Sciences 2020 21(22):8799. doi: 10.3390/ijms21228799.

   >PubMed

3. Kawamura, H., Nojima, T., Oshiro-Ideue, T., Kataoka, N.* and Hagiwara, M.* (2020) (*Corresponding authors)

   RNA binding activity of HSV-2 ICP27 protein
   RNA & DISEASE, 7: e1165. doi: 10.14800/rd.1165

   >Link

4. Matsumoto, S., Porter, CJ., Ogasawara, N., Iwatani, C., Tsuchiya, H., Seita, Y., Chang, YW., Okamoto, I., Saitou, M., Ema, M., Perkins, TJ., Stanford, WL. and Tanaka, S.* (2020) (*Corresponding author)

   Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts
   Scientific Reports 10(1):6827. doi: 10.1038/s41598-020-63602-7.

   >PubMed

5. Masaki, S., Hashimoto, K., Kihara, D., Tsuzuki, C., Kataoka, N. and Suzuki, K. (2020)

   The cysteine residue at 424th of pyruvate kinase M2 is crucial for tetramerization and responsiveness to oxidative stress
   Biochemical and Biophysical Research Communications, 526, 973-977. doi: 10.1016/j.bbrc.2020.03.182

   >PubMed

6. Masaki, S., Kabuto, T., Suzuki, K. and Kataoka, N.* (2020) (*Corresponding author)

   Multiple nuclear localization sequences in SRSF4 protein.
   Genes to Cells, doi: 10.1111/gtc.12756.

   >PubMed

2019年度

1. Chen, R., Sugiyama, A, Takaishi, S, Kataoka, N., Sugimoto, M., Seno, H., Fukuda, A. and Yokoyama, S. (2020)

   Promoter-level transcriptome identifies stemness associated with relatively high proliferation in pancreatic cancer cells
   Frontiers in Oncology, 10:316. doi: 10.3389/fonc.2020.00316.

   >PubMed

2. Hase, K, Contua, VR., Kabuta, C., Sakaia, R., Takahashia, M., Kataoka, N., Hakuno, F., Takahashi, SI, Fujiwara, Y., Wada, K. and Kabuta, T. (2020)

   Cytosolic domain of SIDT2 carries an arginine-1 rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes.
   Autophagy, 2020 Jan 16:1-15. doi: 10.1080/15548627.2020.1712109.

   >PubMed

3. K. Nishitani, K. Hayakawa and S. Tanaka

   Extracellular glucose levels in cultures of undifferentiated mouse trophoblast stem cells affect gene expression during subsequent differentiation with replicable cell line-dependent variation
   J Reprod Dev. 2019 Feb 8;65(1):19-27

   >PubMed

4. Masaki, S.*, Ikeda, S., Hata, A., Shiozawa, Y., Kon, A., Ogawa, S., Suzuki, K., Hakuno, F., Takahashi, S-IT. and Kataoka, N.* (*Corresponding authors)

   Myelodysplastic syndrome-associated SRSF2 mutations cause splicing changes by altering binding motif sequences
   Front Genet. 2019 Apr 16;10:338:

   >PubMed

日本語著書および総説など

1. Nakayama, K.* and Kataoka, N.* (*Corresponding authors)

   Regulation of gene expression under hypoxic conditions
   International Journal of Molecular Sciences, 20(13), 3278; doi.org/10.3390/ijms20133278

   >PubMed

2. Kataoka, N.*, Mayeda, A. and Ohno, K. (*Corresponding author)

   Editorial: RNA Diseases in Humans – From Fundamental Research to Therapeutic Applications
   Frontiers in Molecular Biosciences, 6:53. doi: 10.3389/fmolb.2019.00053

   >PubMed

2018年度

1. K. Hayakawa, K. Terada, T. Takahashi, H. Oana, M. Washimizu and S. Tanaka

   Nucleosomes of polyploid trophoblast giant cells mostly consist of histone variants and form a loose chromatin structure.
   Sci Rep. 2018 Apr 11;8(1):5811.

   >PubMed

2. Furuta, H., Yoshihara, H., Fukushima, T., Yosuke Yoneyama, Y., Ito, A., Worrall, C., Girnita, A., Girnita, L., Minoru Yoshida, M., Asano, T., Komada, M., Kataoka, N., Chida, K., Hakuno, F., and Takahashi1, S-I.

   IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line
   Oncotarget, 9:33871-33883, doi.org/10.18632/oncotarget.26049

   >PubMed

3. Cho, H., Gleghorn, M.L., Rambout, X. Nguyen, P., Phipps, C.R., Miyoshi, K., Fasan, R., Myers, J.R., Kataoka, N. and Maquat, L.E.

   Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target-gene expression
   Genes & Development, 32: 555-567, doi: 10.1101/gad.309773.117.

   >PubMed

4. Nishi, H., Yamanaka, D., Kamei, H., Goda, Y., Kumano, M., Toyoshima, Y., Takenaka, A., Masuda, M., Nakabayashi, Y., Shioya, R., Kataoka, N., Hakuno, F. and Takahashi1, S-I.

   Importance of Serum Amino Acid Profile for Induction of Hepatic Steatosis under Protein Malnutrition
   Scientific Reports, 8: 5461 doi:10.1038/s41598-018-23640-8

   >PubMed

日本語著書および総説など

1. 廣澤瑞子、早川晃司、田中智、塩田邦郎

   ヒストンのグリコシル化
   生体の科学 (特集 タンパク質核酸の分子修飾) p416-417 (2018)

2. M. Hirosawa, K. Hayakawa, K. Shiota and S. Tanaka

   Histone O-GlcNAcylation and Potential Biological Functions
   OBM Genetics 2018; 2(3), doi:10.21926/obm.genet.1803036

3. Kataoka N.

   Modulation of Abnormal Splicing of RNA Diseases by Small Chemical Compounds
   Applied RNA Bioscience (Editors: Seiji Masuda, Shingo Izawa) 115-130, doi.org/10.1007/978-981-10-8372-3_8

4. 片岡直行

   Campus＆Conference探訪記
   40にして惑わず！不惑で魅惑のスプライシング研究
   “40 years of mRNA splicing : From Discovery to Therapeutics” in CSHL
   実験医学36:462-464

2017年度

1. K. Hayakawa, M. Hirosawa, R. Tani, C. Yoneda, S. Tanaka and K. Shiota

   H2A O-GlcNAcylation at serine 40 functions genomic protection in association with acetylated H2AZ or γH2AX.
   Epigenetics Chromatin. 2017 Oct 30;10(1):51.

   >PubMed

2. K. Hayakawa, Y. Sakamoto, O. Konie, A. Ohtake, S. Daikoku, Y. Ito and K. Shiota

   Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells.
   Epigenetics. 2017 Sep;12(9):764-778.

   >PubMed

3. Wang, D.O., Ninomiya, K., Mori, C., Koyama, A., Haan, M., Kitabatake, M., Hagiwara, M., Chida, K., Takahashi, S-I., Ohno, M.* and Kataoka, N.* (*Corresponding authors)

   Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex are associated with microtubules and spatially separated from eIF4E granules and P bodies in Human Neuronal Processes
   Frontiers in Molecular Biosciences, 4: 93. doi: 10.3389/fmolb.2017.00093.

   >PubMed

4. Ohe, K., Yoshida, M., Nakano-Kobayashi, A., Hosokawa, M., Sako, Y., Sakuma, M., Okuno, Y., Usui, T., Ninomiya, K., Nojima, T., Kataoka, N.* and Hagiwara, M.* (*Corresponding authors)

   RBM24 promotes U1 snRNP recognition of the mutated 5' splice site in the IKBKAP gene of familial dysautonomia.
   RNA, 23: 1393-1403, doi:10.1261/rna.059428.116

   >PubMed

日本語著書および総説など

1. Kataoka, N.

   Modulation of aberrant splicing in human RNA diseases by chemical compounds
   Human Genetics, 136: 1237-1245, doi:10.1007/s00439-017-1789-4

   >PubMed

2016年度

1. M. Hirosawa, K. Hayakawa, C. Yoneda, D. Arai, H. Shiota, T. Suzuki, S. Tanaka, N. Dohmae and K. Shiota

   Novel O-GlcNAcylation on Ser40 of canonical H2A isoforms specific to viviparity.
   Sci Rep. 2016 12;6:31785

   >PubMed

2. R. Tani, K. Hayakawa, S. Tanaka and K. Shiota

   Linker histone variant H1T targets rDNA repeats.
   Epigenetics. 2016 Apr 2;11(4):288-302

   >PubMed

3. Ninomiya, K., Ohno, M. and Kataoka, N.* (*Corresponding authors)

   Dendritic Transport Element of human arc mRNA confers RNA degradation activity in a translation-dependent manner.
   Genes to Cells, 21: 1263-1269, doi: 10.1111/gtc.12439.

   >PubMed

4. Fukumura, K., Wakabayashi, S. Kataoka, N., Sakamoto, H., Suzuki, Y., Nakai, K., Mayeda, A. and Inoue, K.

   The Exon Junction Complex Controls the Efficient and Faithful Splicing of a Subset of Transcripts Involved in Mitotic Cell-Cycle Progression.
   International Journal of Molecular Sciences, 17: 1153-1165; doi: 10.3390/ijms17081153

   >PubMed

5. López-Perrote, A., Castaño, R., Melero, R., Zamarro, T., Kurosawa, H., Ohnishi, T., Uchiyama, A., Aoyagi, K., Buchwald, G., Kataoka, N., Yamashita, A. and Llorca, O.

   Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex.
   Nucleic Acids Research, 44:1909-1923. doi: 10.1093/nar/gkv1527.

   >PubMed

日本語著書および総説など

1. K. Hayakawa, M. Hirosawa and K. Shiota

   Analysis of DNA Methylation by Bisulfite Reaction in Neural Cells as an Example of Orexin Neurons.
   Epigenetic Methods in Neuroscience Research. Volume 105 of the series Neuromethods pp 55-63

2. K. Hayakawa, C. Yoneda, R. Tani and K. Shiota

   Analysis of Histone Modifications in Neural Cells as an Example of Orexin Neurons.
   Epigenetic Methods in Neuroscience Research. Volume 105 of the series Neuromethods pp 139-147

3. Kataoka N.

   Purification of RNA-Protein Splicing Complexes Using a Tagged Protein from In Vitro Splicing Reaction Mixture
   RNA-Protein Complexes and Interactions (Editor: Ren-Jang Lin)
   Methods in Molecular Biology 1421: 45-52. doi: 10.1007/978-1-4939-3591-8_5.

   >PubMed

4. 片岡直行、前田明 （特集企画者）

   概論─mRNA前駆体スプライシング−分子機構とその破綻による疾患まで
   実験医学 34:3108-3115

5. 片岡直行

   コーディングRNAからのノンコーディングRNA発現機構
   実験医学 34:3127-3132

2015年度

1. Y. Arai, K. Hayakawa, D. Arai, R. Ito, Y. Iwasaki, K. Saito, K. Akutsu, S. Takatori, R. Ishii, R. Hayashi, S. Izumi, N. Sugino, F. Kondo, M. Horie, H. Nakazawa, T. Makino, M. Hirosawa, K. Shiota and J. Ohgane

   Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells.
   Biomed Res Int. 2015:876047 (2015)

   >PubMed

2. D. Arai, K. Hayakawa, J. Ohgane, M. Hirosawa, Y. Nakao, S. Tanaka and K. Shiota

   An epigenetic regulatory element of the Nodal gene in the mouse and human genomes.
   Mech Dev. May;136:143-54 (2015)

   >PubMed

3. M. Kuwahara, K. Ito, K. Hayakawa, S.Yagi and K. Shiota

   N-Acetylmannosamine improves sleep-wake quality in middle-aged mice: relevance to automatic nervous function.
   Auton Neurosci. Jan;187:56-62 (2015)

   >PubMed

4. S. Ito, K. Hirabayashi, K. Moriishi, Y. Matsui, K. Moriya, K. Koike, Y. Matsuura, K. Shiota and S. Yagi

   Novel sex-dependent differentially methylated regions are demethylated in adult male mouse livers.
   Biochem Biophys Res Commun. 2015 Jul 10;462(4):332-8.

   >PubMed

5. Masaki, S., Kii, I., Sumida, Y, Kato-Sumida, T, Ogawa, Y., Ito, N., Nakamura, M., Sonamoto, R., Kataoka, N., Hosoya, T., and Hagiwara, M.

   Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis
   Bioorganic & Medicinal Chemistry, 23: 4434-4441

   >PubMed

6. Yoshida, M., Kataoka, N.*, Miyauchi, K., Iida, K., Usui, T., Ohe, K., Yoshida, S., Nojima, T., Okuno, Y., Onogi, H., Takeuchi, A., Hosoya, T., Suzuki, T. and Hagiwara, M.* (*Corresponding authors)

   Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia.
   Proceedings of the National Academy of Science, U.S.A., 112: 2764-2769; doi:10.1073/pnas.1415525112

   >PubMed

7. Masaki, S., Yoshimoto, R., Kaida, D., Hata, A., Satoh, T., Ohno, M. and Kataoka, N.* (*Corresponding authors)

   Identification of the specific interactors of the human lariat RNA debranching enzyme 1 protein.
   International Journal of Molecular Sciences, 16: 3705-3721; doi:10.3390/ijms16023705

   >PubMed

日本語著書および総説など

1. K. Hayakawa, E. Himeno, S. Tanaka and T. Kunath

   Isolation and manipulation of mouse trophoblast stem cells.
   Curr Protoc Stem Cell Biol. Feb 2;32:1E.4.1-1E.4.32 (2015)

   >PubMed

2. Kataoka, N.

   Human RNA lariat Debranching Enzyme Protein 1 –A surveillant for branch RNAs for degradation
   RNA & Disease 2: e963. doi: 10.14800/rd.963

2014年度

1. S. Tanaka, MO. Nakanishi and K. Shiota

   DNA methylation and its role in the trophoblast cell lineage.
   Int J Dev Biol. 58(2-4):231-8. (2014)

   >PubMed

2. Melero, R., Uchiyama, A., Castaño, R., Kataoka, N., Kurosawa, H., Ohno, S., Yamashita, A. and Llorca, O.

   Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD.
   Structure, 22: 1105-19. doi: 10.1016/j.str.2014.05.015.

   >PubMed

3. Ozoe, A., Sone, M., Fukushima, T., Kataoka, N., Chida, K., Asano, T., Hakuno, F. and Takahashi, S-I.

   Insulin receptor substrate-1 (IRS-1) associates with small nucleolar RNA which contributes to ribosome biogenesis
   Frontiers in Cancer Endocrinology 5: 24. doi: 10.3389/fendo.2014.00024

   >PubMed

4. Yoshimoto, R., Okawa, K., Yoshida, M., Ohno, M.* and Kataoka, N.* (*Corresponding authors)

   Identification of a novel component C2ORF3 in the lariat-intron complex: Lack of C2ORF3 interferes with pre-mRNA splicing via intron turnover pathway
   Genes to Cells: 19, 78-87

   >PubMed

2013年度

1. M. Takasugi, K. Hayakawa, D. Arai and K. Shiota

   Age- and sex-dependent DNA hypomethylation controlled by growth hormone in mouse liver.
   Mech Ageing Dev. Jul-Aug;134(7-8):331-7 (2013)

   >PubMed

2. K. Hayakawa, M. Hirosawa, Y. Tabei, D. Arai, S. Tanaka, N. Murakami, S. Yagi and K. Shiota

   Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells.
   J. Biol. Chem. in press (2012)

   >PubMed

3. K. Hirabayashi, K. Shiota and S. Yagi

   DNA methylation profile dynamics of tissue-dependent and differentially methylated regions during mouse brain development.
   BMC Genomics 6; 14: 82 (2013)

   >PubMed

4. Ozoe, A., Sone, M., Fukushima, T., Kataoka, N., Arai, T., Chida, K., Asano, T., Hakuno, F. and Takahashi, S-I.

   Insulin Receptor Substrate-1 (IRS-1) Forms a Ribonucleoprotein Complex Associated with Polysomes
   FEBS Letters 587: 2319-2324

   >PubMed

5. Kataoka, N.*, #, Dobashi, I., Hagiwara, M. and Ohno, M#. (*Corresponding author, #Equally contributed authors)

   hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity
   Scientific Reports 3: 1090; DOI:10.1038/srep01090

   >PubMed

日本語著書および総説など

1. S. Ito, M. Hirosawa, K. Hayakawa, S. Yagi, S. Tanaka and K. Shiota

   Epigenetics of Placental Development and Function.
   The Guide to Investigation of Mouse Pregnancy. pp.285-295. Academic Press. Dec (2013)

2. K. Hayakawa, M. Hirosawa and K. Shiota

   A Method for Obtaining Epigenomic Data.
   The Guide to Investigation of Mouse Pregnancy. pp.773-776. Academic Press. Dec (2013)