発表論文
2022
- Fujikura Y, Yamanouchi K, Sugihara H, Hatakeyama M, Abe T, Ato S, Oishi K
“Ketogenic diet containing medium-chain triglyceride ameliorates transcriptome disruption in skeletal muscles of rat models of duchenne muscular dystrophy.”
Biochemistry and Biophysics Reports 32: 101378 (2022)[Biochemistry and Biophysics Reports] - Kihara Y, Tanaka Y, Ikeda M, Homma J, Takagi R, Ishigaki K, Yamanouchi K, Honda H, Nagata S, Yamato M
“In utero transplantation of myoblasts and adipose-derived mesenchymal stem cells to murine models of Duchenne muscular dystrophy does not lead to engraftment and frequently results in fetal death.”
Regenerative Therapy 21: 486-493 (2022)[Regenerative Therapy] - Yamanouchi K, Tanaka Y, Ikeda M, Kato S, Okino R, Nishi H, Hakuno F, Takahashi SI, Chambers J, Matsuwaki T, Uchida K
“Macroglossia and less advanced dystrophic change in the tongue muscle of the Duchenne muscular dystrophy rat.”
Skeletal Muscle volume 12: 24 (2022) [Skeltal Muscle] - Fujikura Y, Kimura K, Yamanouchi K, Sugihara H, Hatakeyama M, Zhuang H, Abe T, Daimon M, Morita H, Komuro I, Oishi K.
“A medium-chain triglyceride containing ketogenic diet exacerbates cardiomyopathy in a CRISPR/Cas9 gene-edited rat model with Duchenne muscular dystrophy.”
Sci Rep 12: 11580 (2022). doi: 10.1038/s41598-022-15934-9.[PubMed]
2021
- Yamanouchi K, Nakamura K, Takeuchi S, Hosoyama T, Matsuwaki T, Nishihara M.
“Suppression of MyoD induces spontaneous adipogenesis in skeletal muscle progenitor cell culture.”
Anim Sci J. 2021 Dec;92(1):e13573. doi: 10.1111/asj.13573.[PubMed] - Teramoto N, Ikeda M, Sugihara H, Shiga T, Matsuwaki T, Nishihara M, Uchida K, Yamanouchi K.
“Loss of p16/Ink4a drives high frequency of rhabdomyosarcoma in a rat model of Duchenne muscular dystrophy. ”
J Vet Med Sci 83: 1416-1424 doi: 10.1292/jvms.21-0243. [PubMed] - Fujikura Y, Sugihara H, Hatakeyama M, Oishi K, Yamanouchi K.
“Ketogenic diet with medium-chain triglycerides restores skeletal muscle function and pathology in a rat model of Duchenne muscular dystrophy.”
FASEB J 35: e21861. doi: 10.1096/fj.202100629R. [PubMed] - Goda Y, Yamanaka D, Nishi H, Masuda M, Kamei Y, Kumano M, Ito K, Katsumata M, Yamanouchi K, Kataoka N, Hakuno F, Takahashi SI.
“Pietary lysine restriction induces lipid accumulation in skeletal muscle through an increase in serum threonine levels in rats.”
J Biol Chem 297: 101179. doi: 10.1016/j.jbc.2021.101179. [PubMed]
2020
- Toyoshima Y, Nakamura K, Tokita R, Teramoto N, Sugihara H, Kato H, Yamanouchi K, Minami S.
“Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats. ”
J Biol Chem 295: 11914-11927. doi: 10.1074/jbc.RA120.013095. [PubMed] - Sugihara H, Kimura K, Yamanouchi K, Teramoto N, Okano T, Daimon M, Morita H, Takenaka K, Shiga T, Tanihata J, Aoki Y, Inoue-Nagamura T, Yotsuyanagi H, Komuro I.
“Age-dependent echocardiographic and pathologic findings in a rat model with Duchenne muscular dystrophy generated by CRISPR/Cas9 genome editing.”
Int Heart J 61: 1279-1284. doi: 10.1536/ihj.20-372. [PubMed] - Teramoto N, Sugihara H, Yamanouchi K, Nakamura K, Kimura K, Okano T, Shiga T, Shirakawa T, Matsuo M, Nagata T, Daimon M, Matsuwaki T, Nishihara M.
“Pathological evaluation of rats carrying in-frame mutations in the dystrophin gene: a new model of Becker muscular dystrophy.”
Dis Model Mech. 2020 Sep 28;13(9):dmm044701. doi: 10.1242/dmm.044701. [PubMed] - Takeuchi S, Yamanouchi K, Sugihara H, Matsuwaki T, Nishihara M.
“Differentiation of skeletal muscle Mesenchymal progenitor cells to myofibroblasts is reversible. ”
Anim Sci J. 2020 Jan-Dec;91(1):e13368. doi: 10.1111/asj.13368.[PubMed] - Kuroda M, Matsuwaki T, Tanaka Y, Yamanouchi K, Nishihara M.
“Convulsive responses to seizure-inducible drugs are exacerbated in progranulin-deficient mice. ”
Neuroreport. 2020 Apr 8;31(6):478-483. doi: 10.1097/WNR.0000000000001425.[PubMed] - Sugihara H, Teramoto N, Nakamura K, Shiga T, Shirakawa T, Matsuo M, Ogasawara M, Nishino I, Matsuwaki T, Nishihara M, Yamanouchi K.
“Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy ”
Sci Rep. 2020 Oct 12;10(1):16385. doi: 10.1038/s41598-020-73315-6.[PubMed]
2019
- Omi S, Yamanouci K, Nakamura K, Matsuwaki T, Nishihara M.
“Reduced fibrillar collagen accumulation in skeletal muscle of secreted protein acidic and rich in cysteine (SPARC)-null mice.”
J Vet Med Sci. 2019 Nov 29;81(11):1649-1654. doi: 10.1292/jvms.19-0485. Epub 2019 Oct 2. [PubMed] [2019年（第81巻）JVMS優秀論文賞]
2018
- Ishiuchi Y, Sato H, Tsujimura K, Kawaguchi H, Matsuwaki T, Yamanouchi K, Nishihara M, Nedachi T.
“Skeletal muscle cell contraction reduces a novel myokine, chemokine (C-X-C motif) ligand 10 (CXCL10): potential roles in exercise-regulated angiogenesis.”
Biosci Biotechnol Biochem. 82: 97-105. [PubMed] - Ishiuchi Y, Sato H, Komatsu N, Kawaguchi H, Matsuwaki T, Yamanouchi K, Nishihara M, Nedachi T.
“Identification of CCL5/RANTES as a novel contraction-reducible myokine in mouse skeletal muscle.”
Cytokine. 108:17-23 [PubMed] - Sugihara H, Miyaji K, Matsuwaki T, Yamanouchi K, Nishihara M.
“Progranulin deficiency leads to prolonged persistence of macrophages, accompanied with myofiber hypertrophy in regenerating muscle.”
J Vet Med Sci.80(2):346-353 [PubMed] - Sugihara H, Teramoto N, Matsuwaki T, Yamanouchi K, Nishihara M.
“Oxidative stress-mediated senescence in mesenchymal progenitor cells causes the loss of their fibro/adipogenic potential and abrogates myoblast fusion”
Aging (Albany NY).10(4):747-763 [PubMed]
2017
- Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M.
“Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.”
Hum Mol Genet 6: 969-988 [PubMed] - Ma Y, Matsuwaki T, Yamanouchi K, Nishihara M
“Glucocorticoids suppress the protective effect of cyclooxygenase-2-related signaling on hippocampal neurogenesis under acute stress conditions.”
Mol Neurobiol 54, 1953-1966. [PubMed] - Matsuwaki T, Komatsuda M, Fujisawa A, Doke M, Yamanouchi K, Nishihara M
“Molecular species of prostaglandins involved in modulating luteinizing hormone pulses under infectious stress conditions.”
J Neuroendocrinol. 29 [PubMed] - Matsuwaki T, Shionoya K, Ihnatko R, Eskilsson A, Kakuta S, Dufour S, Schwaninger M, Waisman A, Müller W, Pinteaux E, Engblom D, Blomqvist A.
“Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses.”
Brain Behav Immun. 66:165-176 [PubMed] - Eskilsson A*, Matsuwaki T*, Shionoya K*, Mirrasekhian E, Zajdel J, Schwaninger M, Engblom D, Blomqvist A.
“Immune-Induced Fever Is Dependent on Local But Not Generalized Prostaglandin E2 Synthesis in the Brain.”
J Neurosci. 37: 5035-5044 [PubMed] - Ma Y, Matsuwaki T, Yamanouchi K, Nishihara M
“Progranulin protects hippocampal neurogenesis via suppression of neuroinflammatory responses under acute immune stress.”
Mol Neurobiol 54: 3717-3728 [PubMed] - Ma Y, Matsuwaki T, Yamanouchi K, Nishihara M
“Involvement of progranulin in modulating neuroinflammatory responses but not neurogenesis in the hippocampus of aged mice.”
Exp Gerontol 95: 1-8 [PubMed] - Tsutiya A, Nakano Y, Hansen-Kiss E, Kelly BJ, Nishihara M, Goshima Y, Corsmeier D, White P, Herman GE, Ohtani-Kaneko R
“Human Crmp4 mutation and disrupted Crmp4 expression in mice associated with ASD characteristics and sexual dimorphism. ”
Sci Rep 7: 16812 [PubMed]
2016
- Ma Y, Matsuwaki T, Yamanouchi K, Nishihara M.
“Progranulin Protects Hippocampal Neurogenesis via Suppression of Neuroinflammatory Responses Under Acute Immune Stress.”
Mol Neurobiol [PubMed] - Doke M, Matsuwaki T, Yamanouchi K, Nishihara M.
“Lack of estrogen receptor α in astrocytes of progranulin-deficient mice.”
J Reprod Dev 62: 547-551 [PubMed] - Takeuchi S, Nakano S, Nakamura K, Ozoe A, Chien P, Yoshihara H, Hakuno F, Matsuwaki T, Saeki Y, Takahashi SI, Yamanouchi K, Nishihara M
“Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues”
Experimental Cell Research 347: 367-377[PubMed] - Nakano S, Nakamura K, Teramoto N, Yamanouchi K, Nishihara M.
“Basic fibroblast growth factor is pro-adipogenic in rat skeletal muscle progenitor clone, 2G11 cells.”
Anim Sci J 87: 99-108. [PubMed] - Tsutiya A, Watanabe H, Nakano Y, Nishihara M, Goshima Y, Ohtani-Kaneko R
“Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb.”
J Anat. 228:792-804. [PubMed] - Murakami S, Endoh M, Kobayashi T, Takenaka-Uema A, Chambers JK, Uchida K, Nishihara M, Hause B, Horimoto T
“influenza D virus infection in herd of cattle, Japan.”
Emerg Infect Dis 22, 1517-1519 [PubMed] - Kawashima K, Ishiuchi Y, Konnai M, Komatsu S, Sato H, Kawaguchi H, Miyanishi N, Lamartine J, Nishihara M, Nedachi T
“Glucose deprivation regulates the progranulin-sortilin axis in PC12 cells.”
FEBS Open Bio 7, 149-159[PubMed] - Ma Y, Matsuwaki T, Yamanouchi K, Nishihara M
“Involvement of progranulin in modulating neuroinflammatory responses but not neurogenesis in the hippocampus of aged mice.”
Exp Gerontol[PubMed]
2015
- Hosokawa M, Arai T, Masuda-Suzukake M, Kondo H, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H.
“Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice.”
J Neuropathol Exp Neurol. 74:158-65.[PubMed] - Tsutiya A, Nishihara M, Goshima Y, Ohtani-Kaneko R
“Mouse pups lacking collapsin response mediator protein 4 manifest impaired olfactory function and hyperactivity in the olfactory bulb.”
Eur J Neurosci. 42:2335-45. [PubMed] - Matsuwaki T, Kobayashi A, Mase K, Nakamura K, Nakano S, Miyoshi T, Yamanouchi K, Nishihara M.
“Possible involvement of the cerebellum in motor-function impairment in progranulin-deficient mice. ”
Neuroreport 26: 877-81. [PubMed] - Kanazawa M, Kawamura K, Takahashi T, Miura M, Tanaka Y, Koyama M, Toriyabe M, Igarashi H, Nakada T, Nishihara M, Nishizawa M, Shimohata T.
“Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke.”
Brain. 138:1932-48. doi: 10.1093/brain/awv079. Epub 2015 Apr 2.[PubMed]
2014
- Nakamura K, Yamanouchi K, Nishihara M.
"Secreted protein acidic and rich in cysteine internalization and its age-related alterations in skeletal muscle progenitor cells."
Aging Cell 13: 175-184 [PubMed] - Ma Y, Matsuwaki T, Yamanouchi K, Nishihara M.
"Differential Roles of Cyclooxygenase-2-Related Signaling in Regulating Hypothalamic Neuronal Activity under Various Acute Stresses."
J Vet Med Sci 76: 219-227 [PubMed] - Takegahara Y, Yamanouchi K, Nakamura K, Nakano SI, Nishihara M.
"Myotube formation is affected by adipogenic lineage cells in a cell-to-cell contact-independent manner."
Exp Cell Res 324: 105-114 [PubMed] - Komatsuda M, Yamanouchi K, Matsuwaki T, Nishihara M.
"Free access to running wheels abolishes hyperphagia in human growth hormone transgenic rats."
J Vet Med Sci 76(7):993-9 [PubMed] - Matsuwaki T, Eskilsson A, Kugelberg U, Jönsson JI, Blomqvist A.
"Interleukin-1β induced activation of the hypothalamus-pituitary-adrenal axis is dependent on interleukin-1 receptors on non-hematopoietic cells."
Brain Behav Immun 40:166-73 [PubMed] - Sato K, Yamanaka Y, Ishii M, Ishibashi K, Ogura Y, Ohtani-Kaneko R, Nishihara M, Nedachi T.
"Dual cell protective mechanisms activated by differing levels of oxidative stress in HT22 murine hippocampal cells."
Biosci Biotech Biochem 78(9):1495-503 [PubMed] - Tanaka Y, Chambers JK, Matsuwaki T, Yamanouchi K, Nishihara M.
"Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice."
Acta Neuropathol Commun 2(1):78 [PubMed] - Nakamura K, Fujii W, Tsuboi M, Tanihata J, Teramoto N, Takeuchi S, Naito K, Yamanouchi K, Nishihara M.
"Generation of muscular dystrophy model rats with a CRISPR/Cas system."
Sci Rep 4: 5635 [PubMed] - Okuda DT, Melmed K, Matsuwaki T, Blomqvist A, Craig AD.
"Central neuropathic pain in MS is due to distinct thoracic spinal cord lesions."
Ann Clin Transl Neurol 8: 554-61 [PubMed]
2013
- Fujisawa A, Matsuwaki T, Yamanouchi K, Nishihara M.
"Possible involvement of neuropeptide Y in photo-induced suppression of growth hormone pulses."
J Vet Med Sci 75: 275-281 [PubMed] - Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M.
"Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice."
Neuroscience. 231: 49-60 [PubMed] - Wu G, Matsuwaki T, Tanaka Y, Yamanouchi K, Hu J, Nishihara M.
"Taurine counteracts the suppressive effect of lipopolysaccharide on neurogenesis in the hippocampus of rats."
Adv Exp Med Biol 775: 111-119 [PubMed] - Nakamura K, Nakano SI, Miyoshi T, Yamanouchi K, Nishihara M.
"Loss of SPARC in mouse skeletal muscle causes myofiber atrophy."
Muscle Nerve 48: 791-9 [PubMed] - Ma Y, Matsuwaki T, Yamanouchi K, Nishihara M.
"Cyclooxygenase-2-related signaling in the hypothalamus plays differential roles in response to various acute stresses."
Brain Res 508: 23-33 [PubMed] - Iwakura T, Sakoh M, Tsutiya A, Yamashita N, Ohtani A, Tsuda MC, Ogawa S, Tsukahara S, Nishihara M, Shiga T, Goshima Y, Kato T, Ohtani-Kaneko R.
"Collapsin response mediator protein 4 affects the number of tyrosine hydroxylase-immunoreactive neurons in the sexually dimorphic nucleus in female mice."
Develop Neuroiol 73: 502-17 [PubMed] - Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M.
"Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice."
Neuroscience 250: 8-19 [PubMed] - Yamanouchi K, Nakamura K, Takegahara Y, Nakano S, Nishihara M.
"Ex vivo bupivacaine treatment results in increased adipogenesis of skeletal muscle cells in the rat."
Anim Sci J 84: 757-63 [PubMed]
2012
- Kim H, Yamanouchi K, Matsuwaki T, Nishihara M.
“Induction of Ski Protein Expression upon Luteinization in Rat Granulosa Cells without a Change in its mRNA Expression.”
J Reprod Dev 58: 254-259. [PubMed] - Nakamura K, Nakano SI, Miyoshi T, Yamanouchi K, Matsuwaki T, Nishihara M.
“Age-related resistance of skeletal muscle-derived progenitor cells to SPARC may explain a shift from myogenesis to adipogenesis.”
Aging. 4(1):40-8. [PubMed] - Seki M, Matsura R, Iwamori T, Nukumi N, Yamanouchi K, Kano K, Naito K, Tojo H.
“Identification of whey acidic protein (WAP) in dog milk.”
Exp Anim 61: 67-70. [PubMed] - Naidansuren PJ, Park CW, Nanjidsuren TM, Park JJ, Yun SJ, Kang MH, Yamanouchi K, Min KS.
“Ovarian and placental expression of 20a-hydroxysteroid dehydrogenase during pregnancy in deer.”
Anim Reprod Sci 130: 63-73. [PubMed] - Nishizawa H, Handayaningsih AE, Iguchi G, Cho Y, Takahashi M, Yamamoto M, Suda K, Kasahara K, Hakuno F, Yamanouchi K, Nishihara M, Seino S, Takahashi SI, Takahashi Y.
“Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans.”
Growth Horm IGF Res 22: 64-68. [PubMed] - Miyoshi T, Nakano SI, Nakamura K, Yamanouchi K, Nishihara M.
“In Vivo Electroporation Induces Cell Cycle Reentry of Myonuclei in Rat Skeletal Muscle.”
J Vet Med Sci 74, 1291-1297. [PubMed]
2011
- Murakami Y, Yada E, Nakano SI, Miyagoe-Suzuki Y, Hosoyama T, Matsuwaki T, Yamanouchi K, Nishihara M.
“Establishment of bipotent progenitor cell clone from rat skeletal muscle.”
Anim Sci J 82: 764-772. [PubMed] - Yonezawa T, Mogi K, Li JY, Sako R, Manabe N, Yamanouchi K, Nishihara M.
“Effects of estrogen on growth hormone pulsatility in peripheral blood and neuropeptide profiles in the cerebrospinal fluid of goats.”
J Reprod Dev 57: 280-287. [PubMed] - Nedachi T, Kawai T, Matsuwaki T, Yamanouchi K, Nishihara M.
“Progranulin enhances neural progenitor cell proliferation through glycogen kinase 3b phosphorylation.”
Neuroscience 185: 106-115. [PubMed] - Rathbone CR, Yamanouchi K, Chen XK, Nevoret-Bell CJ, Rhoads RP, Allen RE.
“Effects of transforming growth factor-beta (TGF-b1) on satellite cell activation and survival during oxidative stress.”
J Muscle Res Cell Motil 32: 99-109. [PubMed] - Asakura R, Matsuwaki T, Shim JH, Yamanouchi K, Nishihara M.
“Involvement of progranulin in the enhancement of hippocampal neurogenesis by voluntary exercise.”
Neuroreport 7: 881-886. [PubMed] - Hakuno F, Yamauchi Y, Kaneko G, Yoneyama Y, Nakae J, Chida K, Kadowaki T, Yamanouchi K, Nishihara M, Takahashi SI.
“Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts.”
PLoS ONE 6: e25655. [PubMed] - Seo KS, Naidansuren P, Kim SH, Yun SJ, Park JJ, Sim BW, Park CW, Nanjidsuren T, Kang MH, Seo H, Ka H, Kim NH, Hwang SY, Yoon JT, Yamanouchi K, Min KS.
“Expression of aldo-keto reductase family 1 member C1 (AKR1C1) gene in porcine ovary and uterine endometrium during the estrous cycle and pregnancy.”
Reprod Biol Endocrinol 9: 139. [PubMed] - Naidansuren P, Park CW, Kim SH, Nanjidsuren T, Park JJ, Yun SJ, Sim BW, Hwang S, Kang MH, Ryu BY, Hwang SY, Yoon JT, Yamanouchi K, Min KS.
“Molecular characterization of bovine placental and ovarian 20α-hydroxysteroid dehydrogenase. ”
Reproduction 142: 723-731. [PubMed] - Hirao J, Nishimura M, Arakawa S, Niino N, Mori K, Furukawa T, Sanbuissho A, Manabe S, Nishihara M, Mori Y.
“Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses.”
J Toxicol Sci 36(1):9-22. [PubMed]
2010
- Matsuwaki T, Asakurs R, Suzuki M, Yamanouchi K, Nishihara M.
“Age-dependent chandes in progranulin expression in mouse brain.”
J Reprod Dev 57(1):113-9. [PubMed] - Matsuwaki T, Nishihara M, Sato T, Yoda T, Iwakura Y, Chida D.
“Functional hypothalamic amenorrhea due to increased CRH tone in melanocortin receptor 2-deficient mice.”
Endcrinology 151(11):5489-96. [PubMed] - Hirao J, Hiino N, Arakawa S, Shibata S, Mori K, Ando Y, Furukawa T, Sanbuissho A, Manabe S, Mori Y, Nishihara M.
“Circadian modulation of hepatic transcriptome in transgenic rats expressing human growth hormone.”
J Toxicol Sci 35, 673-685. [PubMed] - Ahmed Z, Sheng H, Xu YF, Lin WL, Innes A, Yu X, Hou H, Chiba S, Yamanouchi K, Petrucelli L, Nishihara M, Hutton ML, McGowan E, Dickson D, Lewis J.
“Accelerated lipofuscinosis and ubiquitination in knockout mice suggests a role for progranulin in successful aging.”
Am J Pathol 177,311-324. [PubMed] - Yonezawa T, Mogi K, Li JY, Sako R, Manabe N, Yamanouchi K, Nishihara M.
“Correlation between neuropeptide Y profile in the cerebrospinal fluid and growth hormone pulses in the peripheral circulation.”
Neuroendocrinology 91,308-317. [PubMed] - Shibata S, Ueno C, Ito T, Yamanouchi K, Matsuwaki T, Nishihara M.
“Skeletal muscle growth defect in human growth hormone transgenic rat is accompanied by phenotypic changes in progenitor cells.”
Age 32, 239-253. [PubMed] - Yamada M, Tatsumi R, Yamanouchi K, Hosoyama Y, Shiratsuchi S, Sato A, Mizunoya W, Ikeuchi Y, Furuse M, Allen RE.
“High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for re-establishing satellite cell quiescence in vivo.”
Am J Physiol Cell Physiol 298: C465-476. [PubMed] - Iwamori T, Nukumi N, Itoh K, Kano K, Naito K, Kuromaru M, Yamanouchi K, Tojo H.
“Bacteriostatic Activity of Whey Acidic Protein (WAP).”
J Vet Med Sci 72: 621-625. [PubMed] - Ito M, Yamanouchi K, Naito K, Calos MP, Tojo H.
“Site-specific integration of transgene targeting an endogenous lox-like site in early mouse embryos.”
J Appl Genet 52(1), 89-94. [PubMed] - Alam MS, Ohsako S, Matsuwaki T, Zhu XB, Tsunekawa N, Kanai Y, Sone H, Tohyama C, Kurohmaru M
“Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effect of di(n-butyl) phthalate.”
Reproduction, 427-437. [PubMed]
2009
- Adachi S, Fujioka H, Kakehashi C, Matsuwaki T, Nishihara M, Akema T.
“Possible involvement of microglia containing cyclooxygenase-1 in the accumulation of gonadotrophin-releasing hormone in the preoptic area in female rats.”
J Neuroendoc 21, 1029-1037. [PubMed] - Kiyoshi Kano, Ayami Kitamura, Takashi Matsuwaki, Masami Morimatsu, Kunihiko Naito
“Discoidin Domain Receptor 2 (DDR2) is required for maintenance of spermatogenesis in male mice.”
Mol Reprod Dev, 29-37. [PubMed] - Suzuki M, Lee H-C, Kayasuga Y, Chiba S, Nedachi T, Matsuwaki T, Yamanouchi K, Nishihara M.
“Roles of progranulin in sexual differentiation of the developing brain and adult neurogenesis.”
J Reprod Dev, 351-355. [PubMed] - Chiba S, Matsuwaki T, Yamanouchi K, Nishihara M.
“Alteration in anxiety with relation to the volume of the locus ceruleus in progranulin-deficient mice.”
J Reprod Dev, 518-522. [PubMed] - Kuraoka M, Furuta T, Matsuwaki T, Omatsu T, Ishii Y, Kyuwa S, Yoshikawa Y.
“Direct experimental occlusion of the distal middle cerebral artery induces high reproducibility of brain ischemia in mice.”
Exp Anim 58, 19-29. [PubMed] - Dormann D, Capell A, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M, Haass C.
“Proteolytic processing of tar DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties indipendent of progranulin.”
J Neurochem 110, 1082-1094. [PubMed] - Yamanouchi K, Hosoyama T, Murakami Y, Nakano S, Nishihara M.
“Satellite cell differentiation in goat skeletal muscle single fiber culture.”
J Reprod Dev 55, 252-255. [PubMed] - Kiyokawa Y, Takeuchi Y, Nishihara M, Mori Y.
“Main olfactory system mediates social buffering of conditioned fear responses in male rats.”
Eur J Neurosci 29, 777-785. [PubMed] - Hosoyama T, Ishiguro N, Yamanouchi K, Nishihara M.
“Degenerative muscle fiber accelerates adipogenesis of intramuscular cells via RhoA signaling pathway.”
Differentiation 77, 350-359. [PubMed]
2008
- Matsuwaki T, Yamanouchi K, Nishihara M.
“The effect of glucocorticoids on bradykinesia induced by immobilization stress.”
Horm Behav 54, 41-46. [PubMed] - Ban A, Yamanouchi K, Matsuwaki T, Nishihara M.
“In vivo gene transfer of PPARg is insufficient to induce adipogenesis in skeletal muscle.”
J Vet Med Sci 70, 761-767. [PubMed] - Choi JH, Ishida M, Matsuwaki T, Yamanouchi K, Nishihara M.
“Involvement of 20a-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.”
J Reprod Dev 54, 408-412. [PubMed] - 千葉秀一、西原真杉
“ホルモンによる成体神経新生の制御”
Clin Neurosci 26, 893-895.
2007
- Yamanouchi K, Yada E, Ishiguro N, Nishihara M.
“18a-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis.”
Cell Physiol Biochem 20: 791-780. [PubMed] - Kayasuga Y, Chiba S, Suzuki M, Kikusui T, Matsuwaki T, Yamanouchi K, Kotaki H, Horai R, Iwakura Y, Nishihara M.
“Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene.”
Behav Brain Res 185: 110-118. [PubMed] - Ishida M, Choi JH, Hirabayashi K, Matsuwaki T, Suzuki M, Yamanouchi K, Horai R, Sudo K, Iwakura Y, Nishihara M.
“Reproductive phenotypes in mice with targeted disruption of the 20a-hydroxysteroid dehydrogenase gene.”
J Reprod Dev 53: 499-508. [PubMed] - Yamanouchi K, Ban A, Shibata S, Hosoyama T, Murakami Y, Nishihara M.
“Both PPARg and C/EBPa are sufficient to induce transdifferentiation of goat fetal myoblasts to adipocytes.”
J Reprod Dev 53: 563-572. [PubMed] - Fujioka H, Yamanouchi K, Akema T, Nishihara M.
“The effects of GABA on embryonic gonadotropin-releasing hormone neurons in rat hypothalamic primary culture.”
J Reprod Dev 53: 323-331. [PubMed] - Chiba S, Suzuki M, Yamanouchi K, Nishihara M.
“Involvement of granulin in estrogen-induced neurogenesis in the adult rat hippocampus.”
J Reprod Dev 53: 297-307. [PubMed] - Yamanouchi K, Hosoyama T, Murakami Y, Nishihara M.
“Myogenic and adipogenic properties of goat skeletal muscle stem cells.”
J Reprod Dev 53: 51-58. [PubMed] - 松脇貴志、山内啓太郎、西原真杉
“感染ストレス条件下におけるグルココルチコイドの生殖機能維持機構について”
エンドトキシン研究10 2007 8-13. - 松脇貴志、西原真杉
“性ステロイドの中枢作用”
HORMONE FRONTIER in Gynecology 14, 29-35.
2006
- Hozumi H, Yamanouchi K, a Nishihara M.
“Involvement of neuropeptide Y in hyperphagia in human growth hormone transgenic rats.”
J Vet Med Sci 68, 959-965. [PubMed] - Cho Y, Ariga M, Uchijima Y, Kimura K, Rho JY, Furuhata Y, Hakuno F,Yamanouchi K, Nishihara M, Takahashi SI.
“The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats.”
Endocrinology 147(11): 5374-84. [PubMed] - Kim H, Yamanouchi K, Nishihara M.
“Expression of Ski in the granulosa cells of atretic follicles in the rat ovary.”
J Reprod Dev 52: 715-721. [PubMed] - Yamanouchi K, Hosoyama T, Murakami Y, Nishihara M.
“Myogenic and adipogenic properties of goat skeletal muscle stem cells.”
J Reprod Dev 53: 51-58. [PubMed] - Matsuwaki T, Kayasuga Y, Yamanouchi K, Nishihara M.
“Maintenance of Gonadotropin Secretion by Glucocorticoids under Stress Conditions through the Inhibition of Prostaglandin Synthesis in the Brain. ”
Endocrinology 147:1087-1093. [PubMed] - Yada E, Yamanouchi K, Nishihara M.
“Adipogenic Potential of Satellite Cells from Distinct Skeletal Muscle Origins in the Rat.”
J Vet Med Sci 68: 479-486. [PubMed] - Hosoyama T, Yamanouchi K, Nishihara M.
“Role of serum myostatin during thelactation period.”
J Reprod Dev 52: 469-478. [PubMed] - Lee HC, Yamanouchi K, Nishihara M.
“Effects of Perinatal Exposure toPhthalate/Adipate Esters on Hypothalamic Gene Expression and Sexual Behavior in Rats.”
J Reprod Dev 52:J Reprod Dev 52: 343-352. [PubMed] - Yamanouchi K, Yada E, Ishiguro N, Hosoyama T, Nishihara M.
“Increased adipogenicity of cells from regenerating skeletal muscle.”
Exp Cell Res 312:2701-2711. [PubMed]
2005
- Li JY, Suzuki K, Koike Y, Chen DS, Yonezawa T, Nishihara M, Manabe N.
“Effects of dietary supplementation with branched-chain amino acids (BCAAs) during nursing on plasma BCAA levels and subsequent growth in cattle.”
Asian-Aust J Anim Sci 18, 1440-1444. - Ida T, Mori K, Miyazato M, Egi Y, Abe S, Nakahara K, Nishihara M, Kanagawa K, Murakami N.
“Neuromedin S is a novel anoexigenic hormone.”
Endocrinology 146, 4217-4223. [PubMed] - Yonezawa T, Mogi K, Li JY, Sako R, Yamanouchi K, Nishihara M.
“Modulation of growth hormone pulsatility by sex steroids in female goats.”
Endocrinology, 146, 2736-2743. [PubMed] - Jayasekara WSN, Yonezawa T, Ishida M, Yamanouchi K, Nishihara M.
“Expression and possible role of 20 a -hydroxysteroid dehydrogenase in the placenta of the goat.”
J Reprod Dev 51, 265-272. [PubMed] - Hosoyama T, Tachi C, Yamanouchi K, Nishihara M.
“Long term adrenal insufficiency induces skeletal muscle atrophy and increases the serum levels of active form myostatin in rat serum.”
Zool Sci 22, 229-236. [PubMed] - 鈴木正寿、西原真杉
“脳の性分化の分子・遺伝子機構”
Horm Front Gynecol 12, 227-134. - 鈴木正寿、西原真杉
“脳の性分化における分子機構ーグラニュリンの関わり”
性差と医療 2, 157-160.
2004
- Hirabayashi K, Ishida M, Suzuki M, Yamanouchi K, Nishihara M.
“Characterization and functional analysis of the 5'-flanking region of the mouse 20 a -hydroxysteroid dehydrogenase gene.”
Biochem J 382, 975-980. [PubMed] - Yamanouchi K, Yada E, Hozumi H, Ueno C, Nishihara M.
“Analyses of hind leg skeletons in human growth hormone transgenic rats.”
Exp Gerontol 39, 1179-1188. [PubMed] - Suzuki M, Lee HC, Chiba S, Yonezawa T, Nishihara M.
“Effects of methoxychlor exposure during perinatal period on reproductive function after maturation in rats.”
J Reprod Dev 50, 455-461. [PubMed] - Ikemura R, Matsuwaki T, Yamanouchi K, Nishihara M.
“Involvement of endogenous vasopressin in high plasma osmolality-induced anorexia via V1 receptor-mediated mechanism.”
J Vet Med Sci 66, 951-955. [PubMed] - Mogi K, Yonezawa T, Chen DS, Li JY, Suzuki M, Yamanouchi K, Sawasaki T, Nishihara M.
“Relationship between growth hormone (GH) pulses in the peripheral circulation and GH-releasing hormone and somatostatin profiles in the cerebrospinal fluid of goats.”
J Vet Med Sci 66, 1071-1078. [PubMed] - Takagi H, Shibutani M, Lee KY, Lee HC, Nishihara M, Uneyama C, Takigami S, Mitsumori K, Hirose M.
“Lack of modifying effects of genistein on disruption of the reproductive system by perinatal dietary exposure to ethinylestradiol in rats.”
Reprod Toxicol 18, 687-700. [PubMed] - Jayasekara WSN, Yonezawa T, Ishida M, Yamanouchi K, Nishihara M.
“Molecular cloning of goat 20 a -hydroxysteroid dehydrogenase cDNA.”
J Reprod Dev, Dev 50, 323-331. [PubMed] - Matsuwaki T, Suzuki M, Yamanouchi K, Nishihara M.
“Glucocorticoid counteracts the suppressive effect of tumor necrosis factor- a on the surge of luteinizing hormone secretion in rats.”
J Endocrinol 181, 509-513. [PubMed] - 今川和彦、西原真杉
“比較生物学から見た月経の意義”
Horm Front Gynecol 11, 127-132.
2003
- Yonehara K, Suzuki M, Yamanouchi K, Nishihara M.
“Expression analysis of estrogen and androgen target genes in neonatal rat hypothalamus.”
J Reprod Dev 49, 547-552. [PubMed] - Fujioka H, Suzuki M, Yamanouchi K, Ohta A, Nagashima H, Kato M, Nishihara M.
“Generation of transgenic rats expressing enhanced green fluorescent protein in gonadotropin-releasing hormone neurons.”
J Reprod Dev 49, 523-529. [PubMed] - Mogi K, Yonezawa T, Chen DS, Li JY, Sawasaki T, Nishihara M.
“Correlation between spontaneous feeding behavior and neuropeptide Y profile in the cerebrospinal fluid of goats.”
Domestic Animal Endocrinology 25, 175-182. [PubMed]。 - Matsuwaki T, Watanabe E, Suzuki M, Yamanouchi K, Nishihara M.
“Glucocorticoid maintains pulsitile secretion of LH under infectious stress condition.”
Endocrinology 144, 3477-3482. [PubMed] - Kubota K, Suzuki M, Yamanouchi K, Takahashi M, Nishihara M.
“Involvement of activin and inhibin in the regulation of food and water intake in the rat.”
J Vet Med Sci 65, 237-242. [PubMed] - Bannai M, Yoshimoto R, Hori M, Nishiharaa M, Takahashi K, Yamamura H, Taniguchi S, Katsuki M, Ozaki H, Karaki H.
“Increased locomotor activity, increased food and water intake and decreased PVN neurons in h1 calponin gene-deficient mice.”
J Vet Med Sci 65, 153-155. [PubMed] - Ishida M, Hirabayashi K, Suzuki M, Yamanouchi K, Nishihara M.
“Cloning and chromosomal localization of mouse 20 a -hydroxysteroid dehydrogenase gene.”
J Reprod Dev 49, 79-85. [PubMed]
2002
- Furuhata Y, Nishihara M and Takahashi M.
“Effects of pulsatile secretion of growth hormone (GH) on fat deposition in human GH transgenic rats.”
Nutri Res Rev 15, 231-244. [PubMed] - Yonehara K, Suzuki M, Yamanouchi K, Nishihara M.
“Androgen induces p130 mRNA expression in the neonatal rat hypothalamus.”
Neurosci Lett, 334, 107-110. [PubMed] - Narita K, Murata T, Honda K, Nishihara M, Takahashi M, Higuchi T.
“Subthalamic locomotor region is involved in running activity originating in the rat ventromedial hypothalamus.”
Behaiv Brain Res 134, 275-281. [PubMed] - Yonezawa T, Furuhata Y, Hirabayashi K, Suzuki M, Yamanouchi K, Nishihara M.
“Protamine-derived snthetic peptide enhances the efficiency of sperm-mediated gene transfer using liposome-peptide-DNA complex.”
J Reprod Dev 48, 281-286 . - Yonehara K, Suzuki M, Nishihara M.
“Sex-related differences in gene expression in neonatal rat hypothalamus assessed by cDNA microarray analysis.”
Endocrine J 49, 131-137. [PubMed] - Mogi K, Li JY, Suzuki M, Sawasaki T, Takahashi M, Nishihara M.
“Characterization of growth hormone pulsatility in male Shiba goats: Effects of postpubertal castration and intravenous injection of KP102.”
Endocrine J 45, 145-151. [PubMed] - Suzuki M, Nishihara M.
“Granulin precursor gene; a sex-steroid inducible gene involved in sexual differentiation of the rat brain.”
Mol Genet Metab 75, 31-37. [PubMed] - Furuhata Y, Hirabayashi K, Yonezawa T, Takahashi M, Nishihara M.
“Effects of pair-feeding and growth hormone treatment on obese transgenic rats.”
Europ J Endocrinol 146, 245-249. [PubMed] - Furuhata Y, Yonezawa T, Takahashi M, Nishihara M.
“Impaired insulin signaling in the liver of transgenic rats with low circulating growth hormone levels.”
J Endocrinol 172, 127-136. [PubMed] - Suzuki M, Nishihara M.
“Estrogen affects gene expression of estrogen receptors, androgen receptor, and aromatase in the neonatal rat hypothalamus.”
J Reprod Dev 48, 17-23. - 降旗泰史、西原真杉、高橋迪雄
“成長ホルモン分泌不全トランスジェニックラットにおけるインスリン抵抗性と肥満”
内分泌・糖尿病科 15, suppl. 1, 187-194. - 米沢智洋、茂木一孝、山内啓太郎、鈴木正寿、西原真杉
“実験動物における成長ホルモン分泌調節機構”
内分泌・糖尿病科 15, suppl. 1, 19-25.
2001
- Hirabayashi K, Kuranaga E, Suzuki M, Takahashi M, Nishihara M.
“Expression of ovarian 20 a -hydroxysteroid dehydrogenase in rat thymus.”
Endocrine J 48, 557-563. [PubMed] - Yonezawa T, Furuhata Y, Hirabayashi K, Suzuki M, Takahashi M, Nishihara M.
“Detection of transgene in progeny at different developmental stages following testis-mediated gene transfer.”
Mol Reprod Dev 60, 196-201. [PubMed] - Hayashida T, Murakami K, Mogi K, Nishihara M, Nakazato M, Mondal MS, Hori Y, Kojima M, Kangawa K, Murakami N.
“Ghrelin in domestic animals: distribution in stomach and its possible role.”
Domestic Animal Endocrinol 21, 17-24. [PubMed] - Li JY, Shinozaki K, Nishihara M, Sawasaki T, Takahashi M.
“Induction of short ovulatory cycle in shiba-goats by repeated treatments with prostaglandin F2 a.”
J Reprod Dev 47, 97-103. - Suzuki M, Yonezawa T, Fujioka H, Matsumuro M, Nishihara M.
“Induction of granulin precursor gene expression by estrogen treatment in neonatal rat hypothalamus.”
Neurosci Lett 297, 199-202. [PubMed] - 西原真杉
“トランスジェニック動物を用いた有用遺伝子の探索”
学術月報54，23-27.
2000
- Furuhata Y, Kagaya R, Hirabayashi K, Ikeda A, Chang KT, Nishihara M, Takahashi M.
“Development of obesity in transgenic rats with low ciculating growth hormone levels: Involvement of leptin resistance.”
Europ J Endocrinol 143, 535-541. [PubMed] - Suzuki M, Matsumuro M, Hirabayashi K, Ogawara M, Nishihara M, Takahashi M.
“Oocyte-specific expression of granulin precursor (acrogranin) in rat ovary.”
J Reprod Dev 46, 271-277. - Takahashi M, Chang KT, Ikeda A, Nishihara M, Ohta A, Ogawa S.
“A novel method to generate transgenic animals: Testicular mediated gene transfer (TMGT) method. In: Cloned Animal and Placentation. Roberts RM, Yanagimachi R, Kariya T, Hashizume K (eds),”
Yokendo, Tokyo, pp. 55-62. - Hu JM, Ikemura R, Chang KT, Suzuki M, Nishihara M, Takahashi M.
“Expression of cysteine sulfinate decarboxylase mRNA in rat mammary gland.”
J Vet Med Sci 62, 829-834. [PubMed] - Kuranaga E, Kanuka H, Furuhata Y, Yonezawa T, Suzuki M, Nishihara M, Takahashi M.
“Requirement of the Fas ligand-expressing luteal immune cells for regression of corpus luteum.”
FEBS Lett 472, 137-142. [PubMed] - Hu JM, Rho JY, Suzuki M, Nishihara M, Takahashi M.
“Effect of taurine in rat milk on the growth of offspring.”
J Vet Med Sci 62, 693-698. [PubMed] - Kuranaga E, Kanuka H, Hirabayashi K, Suzuki M, Nishihara M, Takahashi M.
“Progesterone is a cell death suppressor that downregulates Fas expression in the corpus luteum.”
FEBS Lett 466, 279-282. [PubMed] - Suzuki M, Bannai M, Matsumuro M, Furuhata Y, Ikemura R, Kuranaga E, Kaneda Y, Nishihara M, Takahashi M.
“Suppression of copulatory behavior by infusion of antisense oligodeoxynucleotide of granulin into the hypothalamus of neonatal male rats.”
Physiol Behav 68, 707-713. [PubMed] - Suzuki M, Nishihara M, Takahashi M.
“Granulin is a sex-steroid inducible gene in the hypothalamus and involved in sexual differentiation of the rat brain.”
J Reprod Dev 46 Suppl, 51-52. [PubMed] - 鈴木正寿、西原真杉、高橋迪雄
“脳の性分化誘導機構に関する分子生物学的解析－グラニュリン遺伝子の単離とその機能－”
J Reprod Dev 46, j51-j57.
1999
- Ishida M, Chang KT, Hirabayashi K, Nishihara M, Takahashi M.
“Cloning of mouse 20 a -hydroxysteroid dehydrogenase cDNA and its mRNA localization during pregnancy.”
J Reprod Dev 45, 321-329. - Yoshida S, Kubota K, Sasaki H, Hasegawa T, Nishihara M, Terada M, Takahashi M.
“26-Cholesterol hydroxylase in rat corpora lutea: a negative regulator of progesterone secretion.”
Biol Reprod 61, 557-562. [PubMed] - Kuranaga E, Kanuka H, Bannai M, Suzuki M, Nishihara M, Takahashi M.
“Fas/Fas ligand system in prolactin-induced apoptosis in rat corpus luteum: possible role of luteal immune cells.”
Biochem Biophys Res Comm 260, 167-173. [PubMed] - Iwamoto Y, Nishihara M, Takahashi M.
“VMH lesions reduce excessive running under the activity-stress paradigm in the rat.”
Physiol Behav 66, 803-808. [PubMed] - Nishihara M, Takeuchi Y, Tanaka T, Mori Y.
“Electrophysiological correlates of pulsatile and surge gonadotrophin secretion.”
Reviews of Reproduction 4, 110-116. [PubMed] - Chang KT, Ikeda A, Hayashi K, Furuhata Y, Nishihara M, Ohta A, Ogawa S, Takahashi M.
“Production of transgenic rats and mice by the testis-mediated gene transfer.”
J Reprod Dev 45, 29-36. - Chang KT, Ikeda A, Hayashi K, Furuhata Y, Bannai M, Nishihara M, Ohta A, Ogawa S, Takahashi M.
“Possible mechanisms for the testis-mediated gene transfer as a new method for producing transgenic animals.”
J Reprod Dev 45, 37-42.