Selected Publications in Dept. Vet. Anat., Univ. of Tokyo
(2002~ present)
Partial male-to-female reprogramming of mouse fetal testis by Sertoli cell ablation.
Development, dev.201660. Abstract
*A Uchida, K Imaimatsu, H Suzuki, X Han, H Ushioda, M Uemura, K Imura-Kishi, R Hiramatsu, HM Takase, Y Hirate, A Ogura, M Kanai-Azuma, A Kudo, Y Kanai (2022)
SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse.
Nature Communications, 10.1038/s41467-022-35465-1. Abstract
* Yamada R, Oguri A, Fujiki K, Shirahige K, Hirate Y, Kanai-Azuma M, Takezoe H, Akimoto Y, Takahashi N, Kanai Y. (2021)
MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode.
Dis. Model Mech., dmm.049251 Abstract
* Yamada R, Oguri A, Fujiki K, Shirahige K, Takezoe H, Takahashi N, Kanai Y. (2021)
Single-cell transcriptional analysis reveals developmental stage-dependent changes in retinal progenitors in the murine early optic vesicle.
Biochem. Biophys. Res. Commun., 543, 80-86. Abstract
* Imura-Kishi K, Uchida A, Tsunekawa N, Suzuki H, Takase HM, Hirate Y, Kanai-Azuma M, Hiramatsu R, Kurohmaru M, Kanai Y. (2021)
Low retinoic acid levels mediate regionalization of Sertoli Valve in the terminal segment of mouse seminiferous tubules.
Sci Rep, 11(1): 1110. Abstract
Yanai S, Baba T, Inui K, Miyabayashi K, Han S, Inoue M, Takahashi F, Kanai Y, Ohkawa Y, Choi, MH, Morohashi K (2021)
Gene expression and functional abnormalities in XX/Sry Leydig cells.
Sci Rep, 11(1): 719. Abstract
* Uemura M, Higashi M, Pattarapanawan M, Takami S, Ichikawa N, Higashiyama H, Furukawa T, Fujishiro J, Fukumura Y, Yao T, Tajiri T, Kanai-Azuma M, Kanai Y. (2020)
Gallbladder wall abnormality in biliary atresia of mouse Sox17 +/- neonates and human infants.
Dis Model Mech, 13(4): dmm042119. Abstract
Saba R, Kitajima K, Rainbow L, Engert S, Uemura M, Ishida H, Kokkinopoulos I, Shintani Y, Miyagawa S, Kanai Y, Kanai-Azuma M, Koopman P, Meno C, Kenny J, Lickert H, Saga Y, Suzuki K, Sawa Y, Yashiro K. (2019)
Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.
Sci Rep, 9(1): 11953. Abstract
Nomura R, Kashimada K, Suzuki H, Zhao L, Hosokawa-Tsuji A, Yagita H, Takagi M, Kanai Y, Bowles J, Koopman P, Kanai-Azuma M, Morio T. (2019)
Nr5a1 suppression during the fetal period optimizes ovarian development by fine-tuning of Notch signaling.
J Cell Sci, pii: jcs223768. Abstract
* Miura K, Harikae K, Nakaguchi M, Imaimatsu K, Hiramatsu R, Tomita A, Hirate Y, Kanai-Azuma M, Kurohmaru M, Ogura A, Kanai Y. (2019)
Molecular and genetic characterization of partial masculinization in embryonic ovaries grafted into male nude mice.
PLoS ONE, 14(3): e0212367. Abstract
Kitadate Y, Jörg DJ, Tokue M, Maruyama A, Ichikawa R, Tsuchiya S, Segi-Nishida E, Nakagawa T, Uchida A, Kimura-Yoshida C, Mizuno S, Sugiyama F, Azami T, Ema M, Noda C, Kobayashi S, Matsuo I, Kanai Y, Nagasawa T, Sugimoto Y, Takahashi S, Simons BD, Yoshida S. (2019)
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.
Cell Stem Cell, 24(1): 79-92. Abstract
* Igarashi H, Uemura, M, Hiramatsu R, Hiramatsu R, Segami S, Pattarapanawan M, Hirate Y, Yoshimura Y, Hashimoto H, Higashiyama H, Sumitomo H, Kurohmaru M, Saijoh Y, Suemizu H, Kanai-Azuma M, Kanai Y. (2018)
Sox17 is essential for proper formation of the marginal zone of extraembryonic endoderm adjacent to a developing mouse placental disk.
Biol. Reprod., 99(3): 578-589. Abstract
* Higashiyama, H., Ozawa, A., Sumitomo, H., Uemura, M., Fujino, K., Igarashi, H., Imaimatsu, K., Tsunekawa, N., Hirate, Y., Kurohmaru, M., Saijoh, Y., Kanai-Azuma, M., and Kanai, Y.. (2017)
Embryonic Cholecystitis and Defective Gallbladder Contraction in the Sox17-haploinsufficient Model of Biliary Atresia.
Development, 144(10):1906-1917. Abstract
Hirate Y., Suzuki, H., Kawasumi, M., Takase, M.H., Igarashi, H., Naquet, P., Kanai, Y., Kanai-Azuma, M. (2016)
Mouse Sox17 haploinsufficiency leads to female subfertility due to impaired implantation.
Sci. Rep., 6, 24171. Abstract
* Aiyama Y, Tsunekawa N, Kishi K, Kawasumi M, Suzuki H, Kanai-Azuma M, Kurohmaru M, Kanai Y. (2015)
A niche for GFRa1-positive spermatogonia in the terminal segments of the seminiferous tubules in hamster testes.
Stem Cells, 33(9):2811-24. Abstract
Rommelaere S, Millet V, Vu Manh TP, Gensollen T, Andreoletti P, Cherkaoui-Malki M, Bourges C, Escaliere B, Du X, Xia Y, Imb ert J, Beutler B, Kanai Y, Malissen B, Malissen M, Tailleux A, Staels B, Galland F, Naquet P. (2014)
Sox17 regulates liver lipid metabolism and adaptation to fasting.
PLoS One, 9(8):e104925. Abstract
Nobuhisa I, Osawa M, Uemura M, Kishikawa Y, Anani M, Harada K, Takagi H, Saito K, Kanai-Azuma M, Kanai Y, Iwama A, Taga T. (2014)
Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters.
Mol. Cell Biol., 34(11):1976-90. Abstract
Kuroki, S., Matoba, S., Akiyoshi, M., Matsumura, Y., Miyachi, H., Mise, N., Abe, K., Ogura, A., Wilhelm, D., Koopman, P., Nozaki, M., Kanai, Y., Shinkai, Y., Tachibana, M. (2013)
Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a.
Science, 341(6150):1106-9. Abstract
Fujimoto, Y., Tanaka, S.S., Yamaguchi, Y.L., Kobayashi, H., Kuroki, S., Tachibana, M., Shinomura, M., Kanai, Y., Morohashi, K., Kawakami, K., Nishinakamura, R. (2013)
Homeoproteins six1 and six4 regulate male sex determination and mouse gonadal development.
Dev. Cell, 26(4):416-30. Abstract
* Harikae, K., Miura, K., Shinomura, M., Matoba, S., Hiramatsu, R., Tsunekawa, N., Kanai-Azuma, M., Kurohmaru, M., Morohashi, K. and Kanai, Y. (2013)
Heterogeneity in Sexual Bipotentiality and Plasticity of Granulosa Cells in Developing Mouse Ovaries.
J. Cell Sci., 126 (13): 2834-44. Abstract
* Uemura, M., Ozawa, A., Nagata, T., Kurasawa, K., Tsunekawa, N., Nobuhisa, I., Taga, T., Hara, K., Kudo, A., Kawakami, H., Saijoh, Y., Kurohmaru, M., Kanai-Azuma, M., and Kanai, Y. (2013)
Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice.
Development, 140 (3), 639-648. Abstract
Saund, R.S., Kanai-Azuma, M., Kanai, Y., Kim, I., Lucero, M.T., Saijoh, Y. (2012)
Gut endoderm is involved in transfer of left right asymmetry from the node to the lateral plate mesoderm in the mouse embryo.
Development, 139(13):2426-35. Abstract
Katoh-Fukui, Y., Miyabayashi, K., Komatsu, T., Owaki A., Baba, T., Shima, Y., Kidokoro, T., Kanai, Y., Schedl, A., Wilhelm, D., Koopman, P., Okuno, Y., Morohashi, K. (2012)
Cbx2, a polycomb group gene, is required for Sry gene expression in mice.
Endocrinology, 153(2):913-24. Abstract
* Sato,T., Aiyama, Y., Ishii-Inagaki, M., Hara, K., Tsunekawa, N., Harikae, K., Uemura-Kamata, M., Shinomura, M., Zhu, X.B., Maeda, S., Kuwahara-Otani, S., Kudo, A., Kawakami, H., Kanai-Azuma, M., Fujiwara, M., Miyamae, Y., Yoshida, S., Seki, M., Kurohmaru, M., Kanai, Y.(2011)
Cyclical and Patch-like GDNF Distribution along the Basal Surface of Sertoli cells in Mouse and Hamster Testes.
PLoS One, 6(12): e28367. Abstract
* Hiramatsu, R., Harikae, K., Tsunekawa, N., Kurohmaru, M., Matsuo, I., Kanai, Y. (2010)
FGF signaling directs a center-to-pole expansion of tubulogenesis in mouse testis differentiation.
Development, 137(2):303-12. Abstract
* Hara, K., Kanai-Azuma, M., Uemura, M., Shitara, H., Taya, C., Yonekawa, H., Kawakami, H., Tsunekawa, N., Kurohmaru, M., Kanai, Y. (2009)
Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis.
Dev. Biol., 330(2):427-39. Abstract
* Hiramatsu, R., Matoba, S., Kanai-Azuma, M., Tsunekawa, N., Katoh-Fukui, Y., Kurohmaru, M., Morohashi, K., Wilhelm, D., Koopman, P, Kanai, Y. (2009)
A critical time window of Sryaction in gonadal sex determination in mice.
Development, 136(1):129-38. Abstract
* Matoba, S., Hiramatsu, R., Kanai-Azuma, M., Tsunekawa, N., Harikae, K., Kawakami, H., Kurohmaru, M., Kanai, Y. (2008)
Establishment of testis-specific SOX9 activation requires high-glucose metabolism in mouse sex differentiation.
Dev. Biol., 324(1):76-87. Abstract
Kimura, T., Tomooka, M., Yamano, N., Murayama, K., Matoba, S., Umehara, H., Kanai, Y., Nakano, T. (2008)
Akt signaling promotes derivation of embryonic germ cells from primordial germ cells.
Development, 135(5):869-79. Abstract
Shimoda, M., Kanai-Azuma, M., Hara, K., Miyazaki, S., Kanai, Y., Monden, M., Miyazaki, J. (2007)
Sox17 plays a substantial role in late-stage differentiation of the extraembryonic endoderm in vitro.
J. Cell Sci., 120, 3859-3869. Abstract
* Ishii, M., Tachiwana, T., Hoshino, A., Tsunekawa, N., Hiramatsu, R., Matoba, S., Kanai-Azuma, M., Kawakami H., Kurohmaru, M., Kanai, Y. (2007)
Potency of testicular somatic environment to support spermatogenesis in XX/Sry transgenic male mice.
Development, 134, 449-454. Abstract
Wilhelm, D., Hiramatsu, R., Mizusaki, H., Widjaja, L., Combes, A.N., Kanai, Y., Koopman, P. (2007)
SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development.
J. Biol. Chem. 282,10553-10560. Abstract
Honda, A., Hirose, M., Hara, K., Matoba, S.,Inoue, K., Hiura, H., Miki, H., Kanai, Y., Kono, T., Shinohara, T., Ogura A. (2007)
Isolation, characterization, and in vitro and in vivo differentiation of putative thecal stem cells.
Proc. Natl. Acad. Sci. USA, 104(30):12389-12394. Abstract
* Matsui, T., Kanai-Azuma, M., Hara K., Matoba, S., Hiramatsu, R., Kawakami, H., Kurohmaru, M., Koopman, P., Kanai Y. (2006)
Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice.
J. Cell Sci., 119 (17): 3513-3526. Abstract
Suzuki, T., Kanai Y., Hara, T., Sasaki, J., Sasaki, T., Kohara, M., Maehama, T., Taya, C., Shitara, H., Yonekawa, H., Frohman, M.A.., Yokozeki, T., Kanaho, Y. (2006)
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development.
Mol. Cell. Biol., 26(16): 6149-6156. Abstract
Sohn, J., Natale, J., Chew, L-J., Belachew, S., Cheng, Y., Aguirre, A., Lytle, J., Kanai-Azuma, M., Kanai, Y., Gallo, V. (2006)
Identification of Sox17 as a transcription factor that regulates oligodendrocyte development.
J. Neurosci., 26(38): 9722-9735. Abstract
Matsuura, R., Kogo, H., Ogaeri, T., Miwa, T., Kuwahara, M., Kanai, Y., Nakagawa, T., Kuroiwa, A., Fujimoto, T., Torihashi, S. (2006)
Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells.
Stem Cells, 24 (3): 624-630. Abstract
* Kidokoro, T., Matoba S., Hiramatsu, R., Fujisawa, M., Kanai-Azuma, M., Taya, C., Kurohmaru, M., Kawakami, H., Hayashi, Y., Kanai, Y., Yonekawa, H. (2005)
Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry Expression during early phases of testis differentiation in mice.
Dev. Biol., 278(2), 511-525. Abstract
* Matoba, S., Kanai, Y., Kidokoro, T., Kanai-Azuma, M., Kawakami, H., Hayashi, Y., Kurohmaru, M. (2005)
A novel Sry-downstream cellular event which preserves the readily available energy source of glycogen in mouse sex differentiation.
J. Cell Sci., 118(7), 1449-1459. Abstract
Tam, P.P., Kanai-Azuma, M., Kanai, Y. (2003)
Endoderm development in vertebrates: lineage differentiation and morphogenetic function.
Curr. Opin. Genet. Dev., 13, 393-400. Abstract
* Kanai-Azuma, M., Kanai, Y., Gad, J.M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P.P.L., Hayashi, Y. (2002)
Depletion of definitive gut endoderm in Sox17-null mutant mice.
Development, 129, 2367-2379. Abstract
