発表論文

2016

Ishihara Y, Shioda C, Bangphoomi N, Sugiura K, Saeki K, Tsuda S, Iwanaga T, Takenaka-Uema A, Kato K, Murakami S, Uchida K, Akashi H, Horimoto T. Akabane virus nonstructural protein NSm regulates viral growth and pathogenicity in a mouse model. J Vet Med Sci. 2016 Oct 1;78(9):1391-1397.

Gong H, Kobayashi K, Sugi T, Takemae H, Horimoto T, Xuan X, Akashi H, Kato K. Pull-down method to access the cell surface receptor for Toxoplasma gondii. Parasitol Int. 2016 Oct;65(5 Pt B):514-515.

Horimoto T, Hiono T, Mekata H, Odagiri T, Lei Z, Kobayashi T, Norimine J, Inoshima Y, Hikono H, Murakami K, Sato R, Murakami H, Sakaguchi M, Ishii K, Ando T, Otomaru K, Ozawa M, Sakoda Y, Murakami S. Nationwide Distribution of Bovine Influenza D Virus Infection in Japan. PLoS One. 2016 Sep 28;11(9):e0163828.

Murakami S, Endoh M, Kobayashi T, Takenaka-Uema A, Chambers JK, Uchida K, Nishihara M, Hause B, Horimoto T. Influenza D Virus Infection in Herd of Cattle, Japan. Emerg Infect Dis. 2016 Aug;22(8):1517-9.

Kato K, Sugi T, Takemae H, Takano R, Gong H, Ishiwa A, Horimoto T, Akashi H. Characterization of a Toxoplasma gondii calcium calmodulin-dependent protein kinase homolog. Parasit Vectors. 2016 Jul 21;9(1):405. doi: 10.1186/s13071-016-1676-1.

Suda Y, Fukushi S, Tani H, Murakami S, Saijo M, Horimoto T, Shimojima M. Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system. Arch Virol. 2016 Jun;161(6):1447-54.

Takenaka-Uema A, Sugiura K, Bangphoomi N, Shioda C, Uchida K, Kato K, Haga T, Murakami S, Akashi H, Horimoto T. Development of an improved reverse genetics system for Akabane bunyavirus. J Virol Methods. 2016 Jun;232:16-20.

Murakoshi F, Ichikawa-Seki M, Aita J, Yaita S, Kinami A, Fujimoto K, Nishikawa Y, Murakami S, Horimoto T, Kato K. Molecular epidemiological analyses of Cryptosporidium parvum virus 1 (CSpV1), a symbiotic virus of Cryptosporidium parvum, in Japan. Virus Res. 2016 Jan 4;211:69-72.

Murakami S, Terasaki K, Makino S. Generation of a Single-Cycle Replicable Rift Valley Fever Vaccine. Methods Mol Biol. 2016;1403:187-206.

 

2015

Takenaka-Uema A, Murata Y, Gen F, Ishihara-Saeki Y, Watanabe K, Uchida K, Kato K, Murakami S, Haga T, Akashi H, Horimoto T. Generation of a Recombinant Akabane Virus Expressing Enhanced Green Fluorescent Protein. J Virol. 2015 Sep;89(18):9477-84.

Inomata A, Murakoshi F, Ishiwa A, Takano R, Takemae H, Sugi T, Cagayat Recuenco F, Horimoto T, Kato K. Heparin interacts with elongation factor 1α of Cryptosporidium parvum and inhibits invasion. Sci Rep. 2015 Jul 1;5:11599.

Horimoto T, Gen F, Murakami S, Iwatsuki-Horimoto K, Kato K, Hisasue M, Sakaguchi M, Nidom CA, Kawaoka Y. Cats as a potential source of emerging influenza virus infections. Virol Sin. 2015 Jun;30(3):221-3.

Yamayoshi S, Fukuyama S, Yamada S, Zhao D, Murakami S, Uraki R, Watanabe T, Tomita Y, Neumann G, Kawaoka Y. Amino acids substitutions in the PB2 protein of H7N9 influenza A viruses are important for virulence in mammalian hosts. Sci Rep. 2015 5:8039.

 

2014

Murakami S, Terasaki K, Ramirez SI, Morrill JC, Makino S. Development of a novel, single-cycle replicable Rift Valley fever vaccine. PLoS Negl Trop Dis. 2014 8(3):e2746.

Yamayoshi S, Yamada S, Fukuyama S, Murakami S, Zhao D, Uraki R, Watanabe T, Tomita Y, Macken C, Neumann G, Kawaoka Y. Virulence-affecting amino acid changes in the PA protein of H7N9 Influenza A viruses. J Virol. 2014 88(6):3127-34.

Mohamed YM, Bangphoomi N, Yamane D, Suda Y, Kato K, Horimoto T, Akashi H. Physical interaction between bovine viral diarrhea virus nonstructural protein 4A and adenosine deaminase acting on RNA (ADAR). Arch Virol. 2014 159(7):1735-41.

Bangphoomi N, Takenaka-Uema A, Sugi T, Kato K, Akashi H, Horimoto T. Akabane virus utilizes alternative endocytic pathways to entry into mammalian cell lines. J Vet Med Sci. 2014 76(11):1471-8.

Katsura H, Piao Z, Iwatsuki-Horimoto K, Akeda Y, Watanabe S, Horimoto T, Oishi K, Kawaoka Y. A bivalent vaccine based on a replication-incompetent influenza virus protects against Streptococcus pneumoniae and influenza virus infection. J Virol. 2014 88(22):13410-7.

Recuenco FC, Takano R, Chiba S, Sugi T, Takemae H, Murakoshi F, Ishiwa A, Inomata A, Horimoto T, Kobayashi Y, Horiuchi N, Kato K. Lambda-carrageenan treatment exacerbates the severity of cerebral malaria caused by Plasmodium berghei ANKA in BALB/c mice. Malar J. 2014 13:487.

Takemae H, Sugi T, Kobayashi K, Murakoshi F, Recuenco FC, Ishiwa A, Inomata A, Horimoto T, Yokoyama N, Kato K, Kato K. Interaction between Theileria orientalis 23-kDa piroplasm membrane protein and heparin. Jpn J Vet Res. 2014 62(1-2):17-24.

Recuenco FC, Kobayashi K, Ishiwa A, Enomoto-Rogers Y, Fundador NG, Sugi T, Takemae H, Iwanaga T, Murakoshi F, Gong H, Inomata A, Horimoto T, Iwata T, Kato K. Gellan sulfate inhibits Plasmodium falciparum growth and invasion of red blood cells in vitro. Sci Rep. 2014 4:4723.

Gong H, Kobayashi K, Sugi T, Takemae H, Ishiwa A, Recuenco FC, Murakoshi F, Xuan X, Horimoto T, Akashi H, Kato K. Characterization and binding analysis of a microneme adhesive repeat domain-containing protein from Toxoplasma gondii. Parasitol Int. 2014 63(2):381-8.

Horimoto T, Gen F, Murakami S, Iwatsuki-Horimoto K, Kato K, Akashi H, Hisasue M, Sakaguchi M, Kawaoka Y, Maeda K. Serological evidence of infection of dogs with human influenza viruses in Japan. Vet Rec. 2014 174(4):96.

 

2013

Watanabe T, Kiso M, Fukuyama S, Nakajima N, Imai M, Yamada S, Murakami S, Yamayoshi S, Iwatsuki-Horimoto K, Sakoda Y, Takashita E, McBride R, Noda T, Hatta M, Imai H, Zhao D, Kishida N, Shirakura M, de Vries RP, Shichinohe S, Okamatsu M, Tamura T, Tomita Y, Fujimoto N, Goto K, Katsura H, Kawakami E, Ishikawa I, Watanabe S, Ito M, Sakai-Tagawa Y, Sugita Y, Uraki R, Yamaji R, Eisfeld AJ, Zhong G, Fan S, Ping J, Maher EA, Hanson A, Uchida Y, Saito T, Ozawa M, Neumann G, Kida H, Odagiri T, Paulson JC, Hasegawa H, Tashiro M, Kawaoka Y.,Characterization of H7N9 influenza A viruses isolated from humans.Nature. 2013 26;501(7468):551-5.

Takemae H, Sugi T, Kobayashi K, Gong H, Ishiwa A, Recuenco FC, Murakoshi F, Iwanaga T, Inomata A, Horimoto T, Akashi H, Kato K: Characterization of the interaction between Toxoplasma gondii rhoptry neck protein 4 and host cellular β-tubulin. Sci Rep 3:3199, 2013.Ishiwa A, Kobayashi K, Takemae H, Sugi T, Gong H, Recuenco FC, Murakoshi F, Inomata A, Horimoto T, Kato K. Effects of dextran sulfates on the acute infection and growth stages of Toxoplasma gondii. Parasitol Res. 2013 112: 4169-4176, .

Sugi T, Kobayashi K, Takemae H, Gong H, Ishiwa A, Murakoshi F, Recuenco FC, Iwanaga T, Horimoto T, Akashi H, Kato K. Identification of mutations in TgMAPK1 of Toxoplasma gondii conferring resistance to 1NM-PP1. International J Parasit. 2013 3:93-101.

Takemae H, Sugi T, Kobayashi K, Gong H, Ishiwa A, Recuenco FC, Murakoshi F, Iwanaga T, Inomata A, Horimoto T, Akashi H, Kato K. Toxoplasma gondii RON4 binds to heparan sulfate of host cell surface. Sci Rep. 2013 3: 3199.

Kobayashi K, Takano R, Takemae H, Sugi T, Ishiwa R, Gong H, Recuenco FC, Iwanaga T, Horimoto T, Akashi H, Kato K. Analyses of interactions between heparin and the apical surface proteins of Plasmodium falciparum. Sci Rep. 2013 3: 3178.

Gong H, Kobayashi K, Sugi T, Takemae H, Ishiwa A, Recuenco FC, Murakoshi F, Xuan X, Horimoto T, Akashi H, Kato K: Characterization and binding analysis of a microneme adhesive repeat domain-containing protein from Toxoplasma gondii. Parasitol Int. 2013 63(3):381-388.

Ozawa, M., Shimojima M, Goto H, Watanabe S, Hatta Y, Kiso M, Furuta Y, Horimoto T, Peters NR, Hoffmann MF, Kawaoka Y: A cell-based high-throughput screening system for influenza A viral RNA transcription/replication inhibitors. Sci Rep. 2013 3:1106.

Gen F, Yamada S, Kato K, Akashi H, Kawaoka Y, Horimoto T: Attenuation of an influenza A virus due to alteration of its hemagglutinin-neuraminidase functional balance in mice. Arch Virol. 2013 158(5):1003-1011.

Murakoshi F, Horimoto T, Kato K. Molecular characterization of Cryptosporidium isolates from calves in Ishikari District, Hokkaido, Japan. J Vet Med Sci. 2013 75(7):837-840.

Iwanaga T, Sugi T, Kobayashi K, Takemae H, Gong H, Ishiwa A, Murakoshi F, Recuenco FC, Horimoto T, Akashi H, Kato K. Characterization of Plasmodium falciparum cdc2-related kinase and the effects of a CDK inhibitor on the parasites in erythrocytic schizogony. Parasit International. 2013 62(5):423-430.

 

2012

Murakami S, Terasaki K, Narayanan K, Makino S. Roles of the coding and noncoding regions of Rift Valley fever virus RNA genome segments in viral RNA packaging. J Virol. 2012 86(7):4034-9.

Yamada S, Shinya K, Takada A, Ito T, Susuki T, Suzuki Y, Le QM, Ebina M, Kasai N, Kida H, Horimoto T, Rivailler P, Chen LM, Donis R, Kawaoka Y: Adaptation of a duck influenza A virus in quail. J Virol. 2012 86(3):1411-1420.

Gong H, Kobayashi K, Sugi T, Takemae H, Kurokawa H, Horimoto T, Akashi H, Kato K: A novel PAN/apple domain- containing protein from Toxoplasma gondii: characterization and receptor identification. PLoS ONE. 2012 7(1):e30169.

Kobayashi K, Takemae H, Sugi T, Gong H, Recuenco FC, Iwanaga T, Horimoto T, Akashi H, Kato K. Approach for the development of antiprotozoal agents and vaccines on the basis of invasion inhibitory effect of heparin. Jpn J Vet Parasitol. 2012 11(1): 23.

Tsuda S, Watanabe S, Masangkay JS, Mizutani T, Alviola P, Ueda N, Iha K, Taniguchi S, Fujii H, Kato K, Horimoto T, Kyuwa S, Yoshikawa Y, Akashi H. Genomic and serological detection of bat coronavirus from bats in the Philippines. Arch Virol. 2012 157(12): 2349-2355.

Katsura H, Iwatsuki-Horimoto K, Fukuyama S, Watanabe S, Sakabe S, Hatta Y, Murakami S, Shimojima M, Horimoto T, Kawaoka Y: A replication-incompetent virus possessing an uncleavable hemagglutinin as an influenza vaccine. Vaccine. 2012 30(42): 6027-6033.

Suda Y, Yamane D, Zahoor MA, Kato K, Horimoto T, Akashi H. Subcellular formation and localization of bovine viral diarrhea virus replication complex. Jpn J Vet Res. 2012 60 (suppl.): 78.

Murakami S, Horimoto T, Ito M, Takano R, Katsura H, Shimojima M, Kawaoka Y. Enhanced growth of influenza vaccine seed viruses in Vero cells mediated by broadening the optimal pH range for virus membrane fusion. J Virol. 2012 86(3):1405-10.

 

2011

Kiso M, Ozawa M, Le MQ, Imai H, Takahashi K, Kakugawa S, Noda T, Horimoto T, and Kawaoka Y: Effect of an asparagine-to-serine mutation at position 294 in neuraminidase on the pathogenicity of highly pathogenic H5N1 influenza A virus. J Virol. 2011 85(10):860-866.

Iwatsuki-Horimoto K, Horimoto T, Tamura D, Kiso M, Kawakami E, Hatakeyama S, Ebihara Y, Koibuchi T, Fujii T, Takahashi K, Shimojima M, Sakai-Tagawa Y, Ito M, Sakabe S, Iwasa A, Takahashi K, Ishii T, Gorai T, Tsuji K, Iwamoto A, and Kawaoka Y: Sero-prevalence of pandemic (H1N1) 2009 influenza A virus among schoolchildren and their parents in Tokyo, Japan. Clin Vaccine Immunol. 2011 18(5):860-866.

Akarsu H, Iwatsuki-Horimoto K, Noda T, Katsura H, Baudin F, Horimoto T, and Kawaoka Y: Structure-based design of NS2 mutants for attenuated influenza A virus vaccines. Virus Res. 2011 155(1):240-248.

Horimoto T, Maeda K, Murakami S, Iwatsuki-Horimoto K, Ito T, Suzuki K, Yokoyama M, and Kawaoka Y: Highly pathogenic avian influenza virus infection in feral raccoons, Japan. Emerg Infect Dis. 2011 17(4):714-717.

Sakabe S, Iwatsuki-Horimoto K, Takano R, Nidom CA, Le MT, Nagamura-Inoue T, Horimoto T, Yamashita N, Kawaoka Y: Cytokine production by primary human macrophages infected with highly pathogenic H5N1 or pandemic H1N1 2009 influenza viruses. J Gen Virol. 2011 92(Pt 6):1428-1434.

Kurokawa H, Kato K, Iwanaga T, Sugi T, Sudo A, Kobayashi K, Gong H, Takemae H, Recuenco FC, Horimoto T, Akashi H. Identification of Toxoplasma gondii cAMP dependent protein kinase and its role in the tachyzoite growth. PLoS One. 2011 6(7): e22492.

Terasaki K, Murakami S, Lokugamage KG, Makino S. Mechanism of tripartite RNA genome packaging in Rift Valley fever virus. Proc Natl Acad Sci U S A. 2011 108(2):804-9.

Sugi T, Kato K, Kobayashi K, Kurokawa H, Takemae H, Gong H, Recuenco FC, Iwanaga T, Horimoto T, Akashi H. 1NM-PP1 treatment of mice infected with Toxoplasma gondii. J Vet Med Sci. 2011 73(10): 1377-1379.

 

2010

Haga T, Horimoto T. Animal Models to Study Influenza Virus Pathogenesis and Control. The Open Antimicrobial Agents Journal. 2010 15-21.

Horimoto T,  Kawaoka Y. Pandemic Influenza. The Open Antimicrobial Agents Journal. 2010 9-14.

Sakabe S, Iwatsuki-Horimoto K, Horimoto T, Nidom CA, Le Mt, Takano R, Kubota-Koketsu R, Okuno Y, Ozawa M, Kawaoka Y. A cross-reactive neutralizing monoclonal antibody protects mice from H5N1 and pandemic (H1N1) 2009 virus infection. Antiviral Res. 2010 88(3):249-55.

Imai H, Shinya K, Takano R, Kiso M, Muramoto Y, Sakabe S, Murakami S, Ito M, Yamada S, Le MT, Nidom CA, Sakai-Tagawa Y, Takahashi K, Omori Y, Noda T, Shimojima M, Kakugawa S, Goto H, Iwatsuki-Horimoto K, Horimoto T, Kawaoka Y. The HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets. PLoS Pathog. 2010 6(9):e1001106.

Tamura D, Fujino M, Ozawa M, Iwatsuki-Horimoto K, Goto H, Sakai-Tagawa Y, Horimoto T, Nirasawa M, Kawaoka Y. Significance of seasonal influenza viruses in the stool of pediatric patients. Pediatr Infect Dis J. 2010 29(6):578-9.

Arii J, Goto H, Suenaga T, Oyama M, Kozuka-Hata H, Imai T, Minowa A, Akashi H, Arase H, Kawaoka Y, Kawaguchi Y. Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1. Nature. 2010 467(7317):859-62.

Arii J, Wang J, Morimoto T, Suenaga T, Akashi H, Arase H, Kawaguchi Y. A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor alpha (PILRalpha) abrogates PILRalpha-dependent viral entry and reduces pathogenesis. J Virol. 2010 84(20):10773-83.

Watanabe S, Masangkay JS, Nagata N, Morikawa S, Mizutani T, Fukushi S, Alviola P, Omatsu T, Ueda N, Iha K, Taniguchi S, Fujii H, Tsuda S, Endoh M, Kato K, Tohya Y, Kyuwa S, Yoshikawa Y, Akashi H. Bat coronaviruses and experimental infection of bats, the Philippines. Emerg Infect Dis. 2010 Aug;16(8):1217-23.

Zahoor MA, Yamane D, Mohamed YM, Suda Y, Kobayashi K, Kato K, Tohya Y, Akashi H. Bovine viral diarrhea virus non-structural protein 5A interacts with NIK- and IKKbeta-binding protein. J Gen Virol. 2010 91(Pt 8):1939-48.

Azab W, Tsujimura K, Maeda K, Kobayashi K, Mohamed YM, Kato K, Matsumura T, Akashi H. Glycoprotein C of equine herpesvirus 4 plays a role in viral binding to cell surface heparan sulfate. Virus Res. 2010 151(1):1-9.

Watanabe S, Maeda K, Suzuki K, Ueda N, Iha K, Taniguchi S, Shimoda H, Kato K, Yoshikawa Y, Morikawa S, Kurane I, Akashi H, Mizutani T. Novel betaherpesvirus in bats. Emerg Infect Dis. 2010 16(6):986-8.

Fujii H, Watanabe S, Yamane D, Ueda N, Iha K, Taniguchi S, Kato K, Tohya Y, Kyuwa S, Yoshikawa Y, Akashi H. Functional analysis of Rousettus aegyptiacus "signal transducer and activator of transcription 1" (STAT1). Dev Comp Immunol. 2010 34(5):598-602.

Sugi T, Kato K, Kobayashi K, Watanabe S, Kurokawa H, Gong H, Pandey K, Takemae H, Akashi H. Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step. Eukaryot Cell. 2010 9(4):667-70.

Azab W, Tsujimura K, Kato K, Arii J, Morimoto T, Kawaguchi Y, Tohya Y, Matsumura T, Akashi H. Characterization of a thymidine kinase-deficient mutant of equine herpesvirus 4 and in vitro susceptibility of the virus to antiviral agents. Antiviral Res. 2010 85(2):389-95.

Iha K, Omatsu T, Watanabe S, Ueda N, Taniguchi S, Fujii H, Ishii Y, Kyuwa S, Akashi H, Yoshikawa Y. Molecular cloning and expression analysis of bat toll-like receptors 3, 7 and 9. J Vet Med Sci. 2010 72(2):217-20.

Kobayashi K, Kato K, Sugi T, Takemae H, Pandey K, Gong H, Tohya Y, Akashi H. Plasmodium falciparum BAEBL binds to heparan sulfate proteoglycans on the human erythrocyte surface. J Biol Chem. 2010 285(3):1716-25.

Watanabe S, Omatsu T, Miranda ME, Masangkay JS, Ueda N, Endo M, Kato K, Tohya Y, Yoshikawa Y, Akashi H. Epizootology and experimental infection of Yokose virus in bats. Comp Immunol Microbiol Infect Dis. 2010 33(1):25-36.

 

2009

Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, Muramoto Y, Tamura D, Sakai-Tagawa Y, Noda T, Sakabe S, Imai M, Hatta Y, Watanabe S, Li C, Yamada S, Fujii K, Murakami S, Imai H, Kakugawa S, Ito M, Takano R, Iwatsuki-Horimoto K, Shimojima M, Horimoto T, Goto H, Takahashi K, Makino A, Ishigaki H, Nakayama M, Okamatsu M, Takahashi K, Warshauer D, Shult PA, Saito R, Suzuki H, Furuta Y, Yamashita M, Mitamura K, Nakano K, Nakamura M, Brockman-Schneider R, Mitamura H, Yamazaki M, Sugaya N, Suresh M, Ozawa M, Neumann G, Gern J, Kida H, Ogasawara K, Kawaoka Y. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature. 2009 20;460(7258):1021-5.

Fujii K, Ozawa M, Iwatsuki-Horimoto K, Horimoto T, Kawaoka Y. Incorporation of influenza A virus genome segments does not absolutely require wild-type sequences. J Gen Virol. 2009  90(Pt 7):1734-40.

Tamura D, Mitamura K, Yamazaki M, Fujino M, Nirasawa M, Kimura K, Kiso M, Shimizu H, Kawakami C, Hiroi S, Takahashi K, Hata M, Minagawa H, Kimura Y, Kaneda S, Sugita S, Horimoto T, Sugaya N, Kawaoka Y. Oseltamivir-resistant influenza a viruses circulating in Japan. J Clin Microbiol. 2009 47(5):1424-7.

Ozawa M, Maeda J, Iwatsuki-Horimoto K, Watanabe S, Goto H, Horimoto T, Kawaoka Y. Nucleotide sequence requirements at the 5' end of the influenza A virus M RNA segment for efficient virus replication. J Virol. 2009 Apr;83(7):3384-8.

Kakugawa S, Shimojima M, Goto H, Horimoto T, Oshimori N, Neumann G, Yamamoto T, Kawaoka Y. Mitogen-activated protein kinase-activated kinase RSK2 plays a role in innate immune responses to influenza virus infection. J Virol. 2009 83(6):2510-7.

Makino A, Horimoto T, Kawaoka Y. Binding properties of GP1 protein of Borna disease virus. J Vet Med Sci. 2009 71(2):243-6.

Horimoto T, Kawaoka Y. Designing vaccines for pandemic influenza. Curr Top Microbiol Immunol. 2009;333:165-76. Review.

Iha K, Omatsu T, Watanabe S, Ueda N, Taniguchi S, Fujii H, Ishii Y, Kyuwa S, Akashi H, Yoshikawa Y. Molecular cloning and sequencing of the cDNAs encoding the bat interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12p40, and tumor necrosis factor-alpha. J Vet Med Sci. 2009 71(12):1691-5.

Sugi T, Kato K, Kobayashi K, Pandey K, Takemae H, Kurokawa H, Tohya Y, Akashi H. Molecular analyses of Toxoplasma gondii calmodulin-like domain protein kinase isoform 3. Parasitol Int. 2009 58(4):416-23.

Kato K, Sudo A, Kobayashi K, Sugi T, Tohya Y, Akashi H. Characterization of Plasmodium falciparum calcium-dependent protein kinase 4. Parasitol Int. 2009 58(4):394-400.

Morimoto T, Arii J, Tanaka M, Sata T, Akashi H, Yamada M, Nishiyama Y, Uema M, Kawaguchi Y. Differences in the regulatory and functional effects of the Us3 protein kinase activities of herpes simplex virus 1 and 2. J Virol. 2009 83(22):11624-34.

Arii J, Kato K, Kawaguchi Y, Tohya Y, Akashi H. Analysis of herpesvirus host specificity determinants using herpesvirus genomes as bacterial artificial chromosomes. Microbiol Immunol. 2009 53(8):433-41.

Watanabe S, Ueda N, Iha K, Masangkay JS, Fujii H, Alviola P, Mizutani T, Maeda K, Yamane D, Walid A, Kato K, Kyuwa S, Tohya Y, Yoshikawa Y, Akashi H. Detection of a new bat gammaherpesvirus in the Philippines. Virus Genes. 2009 39(1):90-3.

Kobayashi K, Kato K, Sugi T, Yamane D, Shimojima M, Tohya Y, Akashi H. Application of retrovirus-mediated expression cloning for receptor screening of a parasite. Anal Biochem. 2009 389(1):80-2.

Yamane D, Zahoor MA, Mohamed YM, Azab W, Kato K, Tohya Y, Akashi H. Microarray analysis reveals distinct signaling pathways transcriptionally activated by infection with bovine viral diarrhea virus in different cell types. Virus Res. 2009 142(1-2):188-99.

Yamane D, Zahoor MA, Mohamed YM, Azab W, Kato K, Tohya Y, Akashi H. Inhibition of sphingosine kinase by bovine viral diarrhea virus NS3 is crucial for efficient viral replication and cytopathogenesis. J Biol Chem. 2009 284(20):13648-59.

Arii J, Uema M, Morimoto T, Sagara H, Akashi H, Ono E, Arase H, Kawaguchi Y. Entry of herpes simplex virus 1 and other alphaherpesviruses via the paired immunoglobulin-like type 2 receptor alpha. J Virol. 2009 83(9):4520-7

Morimoto T, Arii J, Akashi H, Kawaguchi Y. Identification of multiple sites suitable for insertion of foreign genes in herpes simplex virus genomes. Microbiol Immunol. 2009 (3):155-61.

Zahoor MA, Yamane D, Mohamed YM, Kobayashi K, Kato K, Tohya Y, Akashi H. Characterization and application of monoclonal antibodies to bovine viral diarrhea virus nonstructural protein 5A. Arch Virol. 2009 154(11):1745-54.

Yamane D, Zahoor MA, Mohamed YM, Azab W, Kato K, Tohya Y, Akashi H. Activation of extracellular signal-regulated kinase in MDBK cells infected with bovine viral diarrhea virus. Arch Virol. 2009 154(9):1499-503.

Azab W, Kato K, Arii J, Tsujimura K, Yamane D, Tohya Y, Matsumura T, Akashi H. Cloning of the genome of equine herpesvirus 4 strain TH20p as an infectious bacterial artificial chromosome. Arch Virol. 2009 154(5):833-42.

Yamao T, Eshita Y, Kihara Y, Satho T, Kuroda M, Sekizuka T, Nishimura M, Sakai K, Watanabe S, Akashi H, Rongsriyam Y, Komalamisra N, Srisawat R, Miyata T, Sakata A, Hosokawa M, Nakashima M, Kashige N, Miake F, Fukushi S, Nakauchi M, Saijo M, Kurane I, Morikawa S, Mizutani T. Novel virus discovery in field-collected mosquito larvae using an improved system for rapid determination of viral RNA sequences (RDV ver4.0). Arch Virol. 2009 154(1):153-8.

Kato A, Arii J, Shiratori I, Akashi H, Arase H, Kawaguchi Y. Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface. J Virol. 2009 83(1):250-61.

 

2008

Murakami S, Iwasa A, Iwatsuki-Horimoto K, Ito M, Kiso M, Kida H, Takada A, Nidom CA, Mai le Q, Yamada S, Imai H, Sakai-Tagawa Y, Kawaoka Y, Horimoto T. Cross-clade protective immunity of H5N1 influenza vaccines in a mouse model. Vaccine. 2008 26(50):6398-404.

Murakami S, Horimoto T, Mai le Q, Nidom CA, Chen H, Muramoto Y, Yamada S, Iwasa A, Iwatsuki-Horimoto K, Shimojima M, Iwata A, Kawaoka Y. Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells. J Virol. 2008 82(21):10502-9.

Iwatsuki-Horimoto K, Hatta Y, Hatta M, Muramoto Y, Chen H, Kawaoka Y, Horimoto T. Limited compatibility between the RNA polymerase components of influenza virus type A and B. Virus Res. 2008 135(1):161-5.

Song JH, Nguyen HH, Cuburu N, Horimoto T, Ko SY, Park SH, Czerkinsky C, Kweon MN. Sublingual vaccination with influenza virus protects mice against lethal viral infection. Proc Natl Acad Sci U S A. 2008 105(5):1644-9.

Murakami S, Horimoto T, Yamada S, Kakugawa S, Goto H, Kawaoka Y. Establishment of canine RNA polymerase I-driven reverse genetics for influenza A virus: its application for H5N1 vaccine production. J Virol. 2008 82(3):1605-9.

 

2007

Ogawa Y, Sugiura K, Kato K, Tohya Y, Akashi H. Rescue of Akabane virus (family Bunyaviridae) entirely from cloned cDNAs by using RNA polymerase I. J Gen Virol. 2007 88(Pt 12):3385-90.

Ogawa Y, Fukutomi T, Sugiura K, Sugiura K, Kato K, Tohya Y, Akashi H. Comparison of Akabane virus isolated from sentinel cattle in Japan. Vet Microbiol. 2007 124(1-2):16-24.

Omatsu T, Watanabe S, Akashi H, Yoshikawa Y. Biological characters of bats in relation to natural reservoir of emerging viruses. Comp Immunol Microbiol Infect Dis. 2007 30(5-6):357-74.

Horimoto T, Murakami S, Muramoto Y, Yamada S, Fujii K, Kiso M, Iwatsuki-Horimoto K, Kino Y, Kawaoka Y. Enhanced growth of seed viruses for H5N1 influenza vaccines. Virology. 2007 366(1):23-7.

Ozawa M, Goto H, Horimoto T, Kawaoka Y. An adenovirus vector-mediated reverse genetics system for influenza A virus generation. J Virol. 2007 81(17):9556-9.

Youn HJ, Ko SY, Lee KA, Ko HJ, Lee YS, Fujihashi K, Boyaka PN, Kim SH, Horimoto T, Kweon MN, Kang CY. A single intranasal immunization with inactivated influenza virus and alpha-galactosylceramide induces long-term protective immunity without redirecting antigen to the central nervous system. Vaccine. 2007 25(28):5189-98.

Ozawa M, Fujii K, Muramoto Y, Yamada S, Yamayoshi S, Takada A, Goto H, Horimoto T, Kawaoka Y. Contributions of two nuclear localization signals of influenza A virus nucleoprotein to viral replication. J Virol. 2007 81(1):30-41.

 

2006

Yamane D, Kato K, Tohya Y, Akashi H. The double-stranded RNA-induced apoptosis pathway is involved in the cytopathogenicity of cytopathogenic Bovine viral diarrhea virus. J Gen Virol. 2006 87(Pt 10):2961-70.

Omatsu T, Nishimura Y, Bak EJ, Ishii Y, Tohya Y, Kyuwa S, Akashi H, Yoshikawa Y. Molecular cloning and sequencing of the cDNA encoding the bat CD4.Vet Immunol Immunopathol. 2006 111(3-4):309-13.

Makino A, Shimojima M, Miyazawa T, Kato K, Tohya Y, Akashi H. Junctional adhesion molecule 1 is a functional receptor for feline calicivirus. J Virol. 2006 80(9):4482-90.

Arii J, Hushur O, Kato K, Kawaguchi Y, Tohya Y, Akashi H. Construction of an infectious clone of canine herpesvirus genome as a bacterial artificial chromosome. Microbes Infect. 2006 8(4):1054-63.

Okuda Y, Ono M, Shibata I, Sato S, Akashi H. Comparison of the polymerase chain reaction-restriction fragment length polymorphism pattern of the fiber gene and pathogenicity of serotype-1 fowl adenovirus isolates from gizzard erosions and from feces of clinically healthy chickens in Japan. J Vet Diagn Invest. 2006 18(2):162-7.

Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai-Tagawa Y, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada T, Kiso M, Usui T, Murata T, Lin Y, Hay A, Haire LF, Stevens DJ, Russell RJ, Gamblin SJ, Skehel JJ, Kawaoka Y. Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature. 2006 444(7117):378-82.

Horimoto T, Kawaoka Y. Strategies for developing vaccines against H5N1 influenza A viruses. Trends Mol Med. 2006 12(11):506-14. Review.

Muramoto Y, Le TQ, Phuong LS, Nguyen T, Nguyen TH, Sakai-Tagawa Y, Horimoto T, Kida H, Kawaoka Y. Pathogenicity of H5N1 influenza A viruses isolated in Vietnam between late 2003 and 2005. J Vet Med Sci. 2006 68(7):735-7.

Iwatsuki-Horimoto K, Horimoto T, Noda T, Kiso M, Maeda J, Watanabe S, Muramoto Y, Fujii K, Kawaoka Y. The cytoplasmic tail of the influenza A virus M2 protein plays a role in viral assembly. J Virol. 2006 80(11):5233-40.

Muramoto Y, Le TQ, Phuong LS, Nguyen T, Nguyen TH, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Horimoto T, Kida H, Kawaoka Y. Molecular characterization of the hemagglutinin and neuraminidase genes of H5N1 influenza A viruses isolated from poultry in Vietnam from 2004 to 2005. J Vet Med Sci. 2006 68(5):527-31.

Horimoto T, Takada A, Fujii K, Goto H, Hatta M, Watanabe S, Iwatsuki-Horimoto K, Ito M, Tagawa-Sakai Y, Yamada S, Ito H, Ito T, Imai M, Itamura S, Odagiri T, Tashiro M, Lim W, Guan Y, Peiris M, Kawaoka Y. The development and characterization of H5 influenza virus vaccines derived from a 2003 human isolate. Vaccine. 2006 24(17):3669-76.

Muramoto Y, Takada A, Fujii K, Noda T, Iwatsuki-Horimoto K, Watanabe S, Horimoto T, Kida H, Kawaoka Y. Hierarchy among viral RNA (vRNA) segments in their role in vRNA incorporation into influenza A virions. J Virol. 2006 80(5):2318-25.

 

2005

Le QM, Kiso M, Someya K, Sakai YT, Nguyen TH, Nguyen KH, Pham ND, Ngyen HH, Yamada S, Muramoto Y, Horimoto T, Takada A, Goto H, Suzuki T, Suzuki Y, Kawaoka Y. Avian flu: isolation of drug-resistant H5N1 virus. Nature. 2005 437(7062):1108.

Mase M, Eto M, Tanimura N, Imai K, Tsukamoto K, Horimoto T, Kawaoka Y, Yamaguchi S. Isolation of a genotypically unique H5N1 influenza virus from duck meat imported into Japan from China. Virology. 2005 339(1):101-9.

Shinya K, Hatta M, Yamada S, Takada A, Watanabe S, Halfmann P, Horimoto T, Neumann G, Kim JH, Lim W, Guan Y, Peiris M, Kiso M, Suzuki T, Suzuki Y, Kawaoka Y. Characterization of a human H5N1 influenza A virus isolated in 2003. J Virol. 2005 79(15):9926-32.

Horimoto T, Kawaoka Y. Influenza: lessons from past pandemics, warnings from current incidents. Nat Rev Microbiol. 2005 3(8):591-600. Review.

Fujii K, Fujii Y, Noda T, Muramoto Y, Watanabe T, Takada A, Goto H, Horimoto T, Kawaoka Y. Importance of both the coding and the segment-specific noncoding regions of the influenza A virus NS segment for its efficient incorporation into virions. J Virol. 2005 Mar;79(6):3766-74.

Mase M, Tsukamoto K, Imada T, Imai K, Tanimura N, Nakamura K, Yamamoto Y, Hitomi T, Kira T, Nakai T, Kiso M, Horimoto T, Kawaoka Y, Yamaguchi S. Characterization of H5N1 influenza A viruses isolated during the 2003-2004 influenza outbreaks in Japan. Virology. 2005 332(1):167-76.

Phung HT, Tohya Y, Miyazawa T, Akashi H. Characterization of Env antigenicity of feline foamy virus (FeFV) using FeFV-infected cat sera and a monoclonal antibody. Vet Microbiol. 2005 106(3-4):201-7.

Hamano M, Maeda K, Kai K, Mochizuki M, Tohya Y, Akashi H. A novel genetic marker to differentiate feline herpesvirus type 1 field isolates. Vet Microbiol. 2005 106(3-4):195-200.

 

2004

Iwatsuki-Horimoto K, Horimoto T, Fujii Y, Kawaoka Y. Generation of influenza A virus NS2 (NEP) mutants with an altered nuclear export signal sequence. J Virol. 2004 78(18):10149-55.

Horimoto T, Takada A, Iwatsuki-Horimoto K, Kawaoka Y. A protective immune response in mice to viral components other than hemagglutinin in a live influenza A virus vaccine model. Vaccine. 2004 22(17-18):2244-7.

Horimoto T, Iwatsuki-Horimoto K, Hatta M, Kawaoka Y. Influenza A viruses possessing type B hemagglutinin and neuraminidase: potential as vaccine components. Microbes Infect. 2004 6(6):579-83.

Iwatsuki-Horimoto K, Kanazawa R, Sugii S, Kawaoka Y, Horimoto T. The index influenza A virus subtype H5N1 isolated from a human in 1997 differs in its receptor-binding properties from a virulent avian influenza virus. J Gen Virol. 2004 85(Pt 4):1001-5.

Maeda Y, Goto H, Horimoto T, Takada A, Kawaoka Y. Biological significance of the U residue at the -3 position of the mRNA sequences of influenza A viral segments PB1 and NA. Virus Res. 2004 100(2):153-7

Horimoto T, Fukuda N, Iwatsuki-Horimoto K, Guan Y, Lim W, Peiris M, Sugii S, Odagiri T, Tashiro M, Kawaoka Y. Antigenic differences between H5N1 human influenza viruses isolated in 1997 and 2003. J Vet Med Sci. 2004 66(3):303-5.

Kondo T, McGregor M, Chu Q, Chen D, Horimoto T, Kawaoka Y. A protective effect of epidermal powder immunization in a mouse model of equine herpesvirus-1 infection. Virology. 2004 318(1):414-9.

Ichimura N, Shimojima M, Nishimura Y, Tohya Y, Akashi H. Molecular cloning and sequencing of feline CD7. J Vet Med Sci. 2004 66(10):1255-8.

Sakurai Y, Shimojima M, Miyazawa T, Masuoka K, Tohya Y, Akashi H. Identification of the feline CD63 homologue using retrovirus-mediated expression cloning. Vet Immunol Immunopathol. 2004 98(3-4):185-91.

Shimojima M, Nishimura Y, Miyazawa T, Tohya Y, Akashi H. T cell subpopulations mediating inhibition of feline immunodeficiency virus replication in mucosally infected cats. Microbes Infect. 2004 6(3):265-71.

Shimojima M, Miyazawa T, Ikeda Y, McMonagle EL, Haining H, Akashi H, Takeuchi Y, Hosie MJ, Willett BJ. Use of CD134 as a primary receptor by the feline immunodeficiency virus. Science. 2004 303(5661):1192-5.

Nagai M, Hayashi M, Sugita S, Sakoda Y, Mori M, Murakami T, Ozawa T, Yamada N, Akashi H. Phylogenetic analysis of bovine viral diarrhea viruses using five different genetic regions. Virus Res. 2004 99(2):103-13.

Hamano M, Maeda K, Mizukoshi F, Mochizuki M, Tohya Y, Akashi H, Kai K. Genetic rearrangements in the gC gene of the feline herpesvirus type 1. Virus Genes. 2004 28(1):55-60.

 

2003

Horimoto T, Takada A, Iwatsuki-Horimoto K, Hatta M, Goto H, Kawaoka Y. Generation of influenza A viruses with chimeric (type A/B) hemagglutinins. J Virol. 2003 77(14):8031-8.

Kato K, Yokoyama A, Tohya Y, Akashi H, Nishiyama Y, Kawaguchi Y. Identification of protein kinases responsible for phosphorylation of Epstein-Barr virus nuclear antigen leader protein at serine-35, which regulates its coactivator function. J Gen Virol. 2003 84(Pt 12):3381-92.

Nakamura M, Nakamura K, Miyazawa T, Tohya Y, Mochizuki M, Akashi H. Monoclonal antibodies that distinguish antigenic variants of canine parvovirus. Clin Diagn Lab Immunol. 2003 10(6):1085-9.

Shimojima M, Nishimura Y, Miyazawa T, Tohya Y, Akashi H. Phenotypic changes in CD8+ peripheral blood lymphocytes in cats infected with feline immunodeficiency virus. Microbes Infect. 2003 5(13):1171-6.

Hamano M, Maeda K, Mizukoshi F, Une Y, Mochizuki M, Tohya Y, Akashi H, Kai K. Experimental infection of recent field isolates of feline herpesvirus type 1. J Vet Med Sci. 2003 65(8):939-43.

Shimojima M, Nishimura Y, Miyazawa T, Kato K, Tohya Y, Akashi H. CD56 expression in feline lymphoid cells. J Vet Med Sci. 2003 65(7):769-73.

Tsushima Y, Karanis P, Kamada T, Xuan X, Makala LH, Tohya Y, Akashi H, Nagasawa H. Viability and infectivity of Cryptosporidium parvum oocysts detected in river water in Hokkaido, Japan. J Vet Med Sci. 2003 65(5):585-9.

Phung HT, Tohya Y, Shimojima M, Kato K, Miyazawa T, Akashi H. Establishment of a GFP-based indicator cell line to quantitate feline foamy virus. J Virol Methods. 2003 109(2):125-31.

Shimojima M, Miyazawa T, Sakurai Y, Nishimura Y, Tohya Y, Matsuura Y, Akashi H. Usage of myeloma and panning in retrovirus-mediated expression cloning. Anal Biochem. 2003 315(1):138-40.

Nagai M, Sakoda Y, Mori M, Hayashi M, Kida H, Akashi H. Insertion of cellular sequence and RNA recombination in the structural protein coding region of cytopathogenic bovine viral diarrhoea virus. J Gen Virol. 2003 84(Pt 2):447-52.

Tsushima Y, Karanis P, Kamada T, Makala L, Xuan X, Tohya Y, Akashi H, Nagasawa H. Seasonal change in the number of Cryptosporidium parvum oocysts in water samples from the rivers in Hokkaido, Japan, detected by the ferric sulfate flocculation method. J Vet Med Sci. 2003 65(1):121-3.

 

2002

Ito T, Kobayashi Y, Morita T, Horimoto T, Kawaoka Y. Virulent influenza A viruses induce apoptosis in chickens. Virus Res. 2002 84(1-2):27-35.

Shimojima M, Nishimura Y, Miyazawa T, Kato K, Nakamura K, Izumiya Y, Akashi H, Tohya Y. A feline CD2 homologue interacts with human red blood cells. Immunology. 2002 105(3):360-6.

Matsuura Y, Tohya Y, Nakamura K, Shimojima M, Roerink F, Mochizuki M, Takase K, Akashi H, Sugimura T. Complete nucleotide sequence, genome organization and phylogenic analysis of the canine calicivirus. Virus Genes. 2002;25(1):67-73.