in vitro　 (rat)

in vivo　 (rat, CCl₄ model)

HSC

Portal fibroblast

HSC

Portal fibroblast

Marker

quiescent

activated

quiescent

activated

normal
(Disse腔内)

cirrhotic
(Disse腔内，septumとparenchymaの境界領域)

normal
(portal vein及びcentral vein周辺)

cirrhotic
(septum全域)

vitamin A

＋＋＋

-

-

-

vimentin

±

＋

＋＋＋

＋＋＋

＋＋＋

＋＋＋

＋＋＋

＋＋＋

desmin

±

＋＋＋

＋

＋

＋＋＋

＋＋＋

＋＋＋

＋＋

GFAP

＋＋＋

±

-

-〜±

＋＋＋

＋

-

-〜±

a-SMA

-

＋＋

＋＋＋

＋＋＋

-

＋＋

＋＋＋

＋＋＋

VCAM-1

＋＋＋

＋＋＋

-

-

＋＋

＋＋

-

-〜±

NCAM

-

＋＋＋

＋

＋

-

＋＋

＋

＋＋＋

fibulin-2

-

-

＋＋＋

＋＋＋

-〜±

-〜±

＋＋＋

＋＋＋

P100

＋＋＋

＋＋＋

-

-

a2-macroglobulin

-

＋＋＋

-

-

IL-6

-

-

＋＋＋

＋＋＋

CD95L

-

＋＋＋

-

-