1. Naive CD4⁺ T cells exhibit distinct expression patterns of cytokines and cell-surface molecules on their primary response to varying doses of antigen (Wataru Ise, Mamoru Totsuka, Yoshitaka Sogawa, Akio Ametani, Satoshi Hachimura, Takehito Sato, Yoshihiro Kumagai, Sonoko Habu, and Shuichi Kaminogawa.)

Journal of Immunology, 168, 3242-3250 (2002)

2. Antigen presentation by Peryer’s patch cells can induce both Th1- and Th2-type responses depending on antigen dosage, but a different cytokine response pattern from that of spleen cells. (Tadashi Yoshida, Satoshi Hachimura, Mina Ishimori, Fumitaka Kinugasa, Wataru Ise, Mamoru Totsuka, Akio Ametani, and Shuichi Kaminogawa.)

Bioscience, Biotechnology, and Biochemistry, 66, 963-969 (2002)

3. Dietary nucleotides increase the mucosal IgA response and the secretion of transforming growth factor b from intestinal epithelial cells in mice. (Shinya Nagafuchi, Mamoru Totsuka, Satoshi Hachimura, Masao Goto, Takeshi Takahashi, Takaji Yajima, Tamotsu Kuwata, and Shuichi Kaminogawa.)

Cytotechnology, 40, 49-58 (2002)

4. Nucleotides enhance the secretion of interleukin 7 from primary-cultured murine intestinal epithelial cells. (Ryuji Murakami, Kiyoshi Yamada, Shinya Nagafuchi, Satoshi Hachimura, Takeshi Takahashi, Shuichi Kaminogawa, and Mamoru Totsuka.)

Cytotechnology, 40, 59-65 (2002)

5. Murine T cell lines can change CD25 expression patterns as well as proliferation and cell death patterns in response to interleukin 2. (Hiroshi Kano, Akio Ametani, Mamoru Totsuka, and Shuichi Kaminogawa.)

Cytotechnology, 40, 39-48 (2002)

6. CD4⁺CD25^- T cells that express latency-associated peptide on the surface suppress CD4⁺CD45RB^high-induced colitis by a TGF-b-dependent mechanism (Takatoku Oida, Xingmin Zang, Masao Goto, Satoshi Hachimura, Mamoru Totsuka, Shuichi Kaminogawa, and Howard L. Weiner.)

Journal of Immunology, 170, 2516-2522 (2003)

7. Antigen feeding enhances frequency and antigen-specific proliferation ability of intraepithelial CD4⁺ T cells in ab T cell receptor transgenic mice (Masao Goto, Satoshi Hachimura, Akio Ametani, Takehito Sato, Yoshihiro Kumagai, Sonoko Habu, Mamoru Totsuka, Hiromichi Ishikawa, and Shuichi Kaminogawa)

Bioscience, Biotechnology, and Biochemistry, 67, 1223-1229 (2003)

8. Interleukin 12 and CD86 regulate T helper type 1 and type 2 development induced by various doses of antigen in the antigen presentation by Peyer’s patch and spleen cells (Tadashi Yoshida, Satoshi Hachimura, Mina Ishimori1, Wataru Ise, Mamoru Totsuka, Akio Ametani, and Shuichi Kaminogawa.)

Cytotechnology, 43 (1), 81-88 (2003)

9. Dendritic cells from spleen, mesenteric lymph node and Peyer’s patch can induce both production of IL-4 and IFN-g of naive CD4⁺ T cells in their primary culture, depending on antigen doses (Masanobu Hibi, Satoshi Hachimura, Wataru Ise, Ayuko Sato, Tadashi Yoshida, Tsuyoshi Takayama, Kastumi Sasaki, Takashi Senga, Shuichi Hashizume, Mamoru Totsuka, and Shuichi Kaminogawa.)

Cytotechnology, 43 (1), 49-55 (2003)

10. Candida albicans and Saccharomyces cerevisiae induce interleukin-8 production from intestinal epithelial-like Caco-2 cells in the presence of butyric acid (Shizue Saegusa, Mamoru Totsuka, Shuichi Kaminogawa, and Tomohiro Hosoi)

FEMS Immunology & Medical Microbiology, 41, 227-235 (2004)

11. T-cell receptor antagonist modifies cytokine secretion profile of naive CD4+ T cells and their differentiation into type-1 and type-2 helper T cells. (Rumi Takato-Kaji, Mamoru Totsuka, Wataru Ise, Megumi Nishikawa, Satoshi Hachimura and Shuichi Kaminogawa)

Immunology Letters, 96 (1), 39-45 (2005).

12. Dietary unripe apple polyphenol inhibits the development of food allergies in murine models. (Hiroshi Akiyama, Yuji Sato, Takahiro Watanabe, Megumi H. Nagaoka, Yasuo Yoshioka, Toshihiko Shoji, Tomomasa Kanda, Kiyoshi Yamada, Mamoru Totsuka, Reiko Teshima, Jun-ichi Sawada, Yukihiro Goda, Tamio Maitani)

FEBS Letters, 579 (20), 4479-4484 (2005).