准教授　角田 茂

Associate Profesor, Shigeru Kakuta, Ph.D., D.V.M.

赴任前（2006-2013.1）の研究業績

論文、総説、著書

Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Horiguchi CS, Ogawa D, Matsuki Y, Hiramatsu R, Yagita H, Kakuta S, Iwakura Y, Makino H. Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex. Diabetes. 2012 Nov;61(11):2823-32. doi: 10.2337/db12-0232. Epub 2012 Jul 26.

Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich BG, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R. In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling. Blood. 2012 Feb 23;119(8):e45-56. Epub 2011 Nov 16.

Nakamura Y, Terahara M, Iwamoto T, Yamada K, Asano M, Kakuta S, Iwakura Y, Totsuka M. Up-regulation of polymeric immunoglobulin receptor expression by the heat-inactivated potential probiotic Bifidobacterium bifidum OLB6378 in a mouse intestinal explant model. Scand J Immunol. 2012 Feb 23;75(2):176-83. Epub 2011 Oct 3.

Yan H, Kakuta S, Nishihara M, Sugi M, Adachi Y, Ohno N, Iwakura Y, Tsuji NM. Kjellmaniella crassifolia Miyabe (Gagome) Extract Modulates Intestinal and Systemic Immune Responses. Biosci Biotechnol Biochem. 2011 Nov 23;75(11):2178-83. Epub 2011 Nov 7.

Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. EMBO J. 2011 Sep 23; 30(23): 4739-54.

Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, Goto Y, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C. A tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe. 2011 May 19;9(5):376-89.

Nakajima A, Matsuki T, Komine M, Asahina A, Horai R, Nakae S, Ishigame H, Kakuta S, Saijo S, Iwakura Y. TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn-/- Mice. J Immunol. 2010 Aug 1;185(3):1887-93. Epub 2010 Jul 7.

Hadano S, Yoshii Y, Otomo A, Kunita R, Suzuki-Utsunomiya K, Pan L, Kakuta S, Iwasaki Y, Iwakura Y, Ikeda JE. Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice. Neurosci Res. 2010 Oct;68(2):131-6. Epub 2010 Jun 14.

Saijo S, Ikeda S, Yamabe K, Kakuta S, Ishigame H, Akitsu A, Fujikado N, Kusaka T, Kubo S, Chung SH, Komatsu R, Miura N, Adachi Y, Ohno N, Shibuya K, Yamamoto N, Kawakami K, Yamasaki S, Saito T, Akira S, Iwakura Y. Dectin-2 recognition of a-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity. 2010 May 28;32(5):681-91. Epub 2010 May 20.

Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watanabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T. Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior. EMBO J., 2009 Dec 2; 28(23):3717-29.

Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity, 2009 Jan;30:108-19.

Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, Kakuta S, Sudo K, Iwakura Y, Shibutani M, Mitsumori K, Yokota J, Yamamoto T. Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Cancer Sci., 2009 Jan;100(2):225-232.

Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Nagai R, Tobe K, Terauchi Y, Ueki K, Kadowaki T. Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding. Cell Metab 2008 July 2; 8(1):49-64.

Ohsugi M, Adachi K, Horai R, Kakuta S, Sudo K, Kotaki H, Tokai-Nishizumi N, Sagara H, Iwakura Y, Yamamoto T. Kid-Mediated Chromosome Compaction Ensures Proper Nuclear Envelope Formation. Cell 2008 Mar 7;132(5):771-782.

Chida D, Nakagawa S, Nagai S, Sagara H, Katsumata H, Imaki T, Suzuki H, Mitani F, Ogishima T, Shimizu C, Kotaki H, Kakuta S, Sudo K, Koike T, Kubo M, Iwakura Y. Melanocortin receptor 2 is required for adrenal gland development, steroidogenesis and neonatal gluconeogenesis. Proc Natl Acad Sci U S A 2007 Nov 13;104(46):18205-18210. Epub 2007 Nov 7.

Kina S, Tezuka T; Kusakawa S, Kishimoto Y, Kakizawa S, Hashimoto K, Ohsugi M, Kiyama Y, Horai R, Sudo K, Kakuta S, Iwakura Y, Iino M, Kano M, Manabe T, Yamamoto T. Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. Eur J Neurosci. 2007 Oct;26(8):2269-78.

Nakatani Y, Hokonohara Y, Kakuta S, Sudo K, Iwakura Y, Kudo I. Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal. Biochem Biophys Res Commun. 2007 Oct 19;362(2):387-92. Epub 2007 Aug 9.

Zhao Z, Satsu H, Fujiwara M, Hori M, Ishimoto Y, Totsuka M, Nambu A, Kakuta S, Ozaki H, Shimizu M. Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers. Amino Acids. 2008 Jun;35(1):217-24. Epub 2007 Jul 6.

Venkataraman T, Valdes M, Elsby R, Kakuta S, Caceres G, Saijo S, Iwakura Y, Barber GN. Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses. J Immunol. 2007 May 15;178(10):6444-55.

Okada K, Inoue A, Okada M, Murata Y, Kakuta S, Jigami T, Kubo S, Shiraishi H, Eguchi K, Motomura M, Akiyama T, Iwakura Y, Higuchi O, Yamanashi Y. The Muscle Protein Dok-7 Is Essential for Neuromuscular Synaptogenesis. Science, 2006 Jun 23; 312(5781):1802-5.

Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, Horai R, Sudo K, Iwakura Y. IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis. J Immunol, 2006 Jul 1; 177(1):566-73.

Zhao Z, Hyun JS, Satsu H, Kakuta S, Shimizu M. Oral exposure to cadmium chloride triggers an acute inflammatory response in the intestines of mice, initiated by the over-expression of tissue macrophage inflammatory protein-2 mRNA. Toxicol Lett 2006 Jul 1;164(2):144-54. Epub 2006 Jan 18.

Ishigame H, Nakajima A, Saijo S, Komiyama Y, Nambu A, Matsuki T, Nakae S, Horai R, Kakuta S, Iwakura Y. The role of TNFalpha and IL-17 in the development of excess IL-1 signaling-induced inflammatory diseases in IL-1 receptor antagonist-deficient mice. Ernst Schering Res Found Workshop. 2006;(56):129-53.

Hadano S, Benn SC, Kakuta S, Otomo A, Sudo K, Kunita R, Suzuki-Utsunomiya K, Mizumura H, Shefner JM, Cox GA, Iwakura Y, Brown Jr RH, Ikeda J-E. Mice Deficient in the Rab5 Guanine Nucleotide Exchange Factor ALS2/alsin Exhibit Age-Dependent Neurological Deficits and Altered Endosome Trafficking. Hum Mol Genet 2006 Jan 15;15(2):233-50. Epub 2005 Dec 1.

 

角田茂、岩倉洋一郎．ノックアウトマウス作製技術の進歩と網羅的作製プロジェクト．生物工学会誌 90(9): 547-549, 2012（総説）

角田茂、岩倉洋一郎．遺伝子改変動物．新しい薬学事典（笠原忠、木津純子、諏訪俊男　編）朝倉書店 pp.121-125, 2012（著書）

角田茂．IL-1関連遺伝子ノックアウトマウスライブラリ作製の話．細胞工学 31(7): 779-781, 2012（解説）

角田茂、西城忍．真菌免疫応答におけるC型レクチン受容体の役割．化学療法の領域　28(1): 59-66, 2012（総説）

角田茂．リウマチ．論文ができてしまう！疾患モデルマウス表現型解析指南（山村研一、若菜茂晴　編）中山書店pp.316-321, 451-454, 2011（著書）

角田茂、岩倉洋一郎．IL-1．series モデル動物利用マニュアル　免疫疾患　−疾患モデルの作製と利用（岩倉洋一郎　編）エル・アイ・シー pp.215-222, 2011（著書）

角田茂、佐藤希、久保幸子、岩倉洋一郎．アグリゲーション法によるキメラマウスの作製．改訂第５版 新 遺伝子工学ハンドブック（松村正實、山本雅、岡﨑康司　編）羊土社 pp.289-296, 2010（著書）

角田茂、岩倉洋一郎．コンディショナルターゲティング法．改訂第５版 新 遺伝子工学ハンドブック（松村正實、山本雅、岡﨑康司　編）羊土社 pp.297-302, 2010（著書）

角田茂、西城忍、岩倉洋一郎．真菌感染とIL-17．炎症と免疫　17(1): 10(10)-20(20), 2009（総説）

角田茂、岩倉洋一郎．自然免疫認識受容体遺伝子欠損マウスの作製と解析．食品と科学　別冊　73-76, 2008（総説）

角田茂．用語解説 IL-23．分子細胞治療　6(4): 88(382)-89(383), 2007（解説）

角田茂．2’,5’-オリゴアデニル酸合成酵素機能の研究の現状．JSICR Newsletter 23: 10-11, 2007（総説）

角田茂．インターフェロンによる抗ウイルス機構「2-5Aシステム」．炎症と免疫 15(2): 26(190)-32(196), 2007（総説）

角田茂、岩倉洋一郎．発生工学技術による動物個体での遺伝子改変と医科学研究．基本からゲノム医療までわかる　遺伝子工学集中マスター（山本雅、仙波憲太郎　編）羊土社　pp.74-83, 2006（著書）

角田茂、岩倉洋一郎．サイトカインと自己免疫疾患．EXPERT 膠原病・リウマチ　改訂第２版（住田孝之　編）診断と治療社　pp.42-47, 2006（著書）

角田茂．ノックアウトマウスの岩倉研式集団一括管理術．JSI Newsletter 14(1):  22, 2006（解説）