最近の業績(2011-17)原著論文

Nakamura S, Ito Y, Yamamoto K, Takahashi C, Dai M, Tanahashi M, Uenoyama Y, Tsukamura H, Oishi S, Maeda KI, Matsuda F. (2017) SB223412, a neurokinin-3 receptor-selective antagonist, suppresses testosterone secretion in male guinea pigs. Theriogenology 102: 183–189.

Watanabe Y, Ikegami K, Ishigaki R, Ieda N, Uenoyama Y, Maeda KI, Tsukamura H, Inoue N. (2017) Enhancement of the luteinising hormone surge by male olfactory signals is associated with anteroventral periventricular Kiss1 cell activation in female rats. J Neuroendocrinol doi: 10.1111/jne.12505.

Ikegami K, Minabe S, Ieda N, Goto T, Sugimoto A, Nakamura S, Inoue N, Oishi S, Maturana AD, Sanbo M, Hirabayashi M, Maeda KI, Tsukamura H, Uenoyama Y. (2017) Evidence of involvement of neurone-glia/neurone-neurone communications via gap junctions in synchronised activity of KNDy neurones. J Neuroendocrinol doi: 10.1111/jne.12480.

Minabe S, Ieda N, Watanabe Y, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H. (2017) Long-term neonatal estrogen exposure causes irreversible inhibition of LH pulses by suppressing arcuate kisspeptin expression via estrogen receptors α and β in female rodents. Endocrinology 158: 2918–2929.

Nakamura S, Uenoyama Y, Ikegami K, Dai M, Watanabe Y, Takahashi C, Hirabayashi M, Tsukamura H, Maeda KI. (2016) Neonatal kisspeptin is steroid-independently required for defeminisation and peripubertal kisspeptin-induced testosterone is required for masculinisation of the brain: A behavioural study using Kiss1 KO rats. J Neuroendocrinol doi: 10.1111/jne.12409.

Hassaneen ASA, Naniwa Y, Suetomi Y, Matsuyama S, Kimura K, Ieda N, Inoue N, Uenoyama Y, Tsukamura H, Maeda KI, Matsuda F, Ohkura S. (2016) Immunohistochemical characterization of the arcuate kisspeptin/neurokinin B/dynorphin (KNDy) and preoptic kisspeptin neuronal populations in the hypothalamus during the estrous cycle in heifers. J Reprod Dev 62: 471-477.

Yamamoto K, Okazaki S, Ohno H, Matsuda F, Ohkura S, Maeda KI, Fujii N, Oishi S. (2016) Development of novel NK3 receptor antagonists with reduced environmental impact. Bioorg Med Chem 24: 3494–3500.

Misu R, Yamamoto K, Yamada A, Noguchi T, Ohno H, Yamamura T, Okamura H, Matsuda F, Ohkura S, Oishi S, Fujii N. (2015) Structure–activity relationship study on senktide for development of novel potent neurokinin-3 receptor selective agonists. Med Chem Comm 6: 469–476.

Uenoyama Y, Tanaka A, Takase K, Yamada S, Pheng V, Inoue N, Maeda KI, Tsukamura H. (2015) Central estrogen action sites involved in prepubertal restraint of pulsatile luteinizing hormone release in female rats. J Reprod Dev 61: 351-359.

Minabe S, Deura C, Ikegami K, Goto T, Sanbo M, Hirabayashi M, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H (2015) Pharmacological and morphological evidence of AMPK-mediated energy sensing in the lower brain stem ependymocytes to control reproduction in female rodents. Endocrinology 156: 2278-2287.

Uenoyama Y, Nakamura S, Hayakawa Y, Ikegami K, Watanabe Y, Deura C, Minabe S, Tomikawa J, Goto T, Ieda N, Inoue N, Sanbo M, Tamura C, Hirabayashi M, Maeda KI, Tsukamura H. (2015) Lack of pulse and surge modes and glutamatergic stimulation of LH release in Kiss1 knockout rats. J Neuroendocrinol 27:187-197.

Matsuda F, Nakatsukasa K, Suetomi Y, Naniwa Y, Ito D, Inoue N, Wakabayashi Y, Okamura H, Maeda KI, Uenoyama Y, Tsukamura H, Ohkura S. (2015) The LH surge-generating system is functional in male goats as in females: involvement of kisspeptin neurones in the medial preoptic area. J Neuroendocrinol 27:57–65.

Goto T, Tomikawa J, Ikegami K, Minabe S, Abe H, Fukanuma T, Imamura T, Takase K, Sanbo M, Tomita K, Hirabayashi M, Maeda KI, Tsukamura H, Uenoyama Y. (2015) Identification of hypothalamic arcuate nucleus-specific enhancer region of Kiss1 gene in mice. Mol Endocrinol 29:121-129.

Watanabe Y, Uenoyama Y, Suzuki J, Takase K, Suetomi Y, Ohkura S, Inoue N, Maeda KI, Tsukamura H. (2014) Oestrogen-induced activation of preoptic kisspeptin neurones may be involved in the luteinizing hormone surge in male and female Japanese monkeys. J Neuroendocrinol 26: 909-917.

Ieda N, Uenoyama Y, Tajima Y, Nakata T, Kano M, Naniwa Y, Watanabe Y, Minabe S, Tomikawa J, Inoue N, Matsuda F, Ohkura S, Maeda KI, Tsukamura H. (2014) KISS1 gene expression in the developing brain of female pigs in pre- and peripubertal periods. J Reprod Dev 60: 312-316.

Uenoyama Y, Tsukamura H, Maeda K. (2014) KNDy neuron as a gatekeeper of puberty onset. J Obset Gynaecol Res. 40(6): 1518-26.

Kaneda M, Misu R, Ohno H, Hirasawa A, Ieda N, Uenoyama Y, Tsukamura H, Maeda KI, Oishi S, Fujii N. (2014) Design and synthesis of fluorescent probes for GPR54. Bioorg Med Chem. pii: S0968-0896(14)00317-4.

Sakakibara M, Uenoyama Y, Minabe S, Watanabe Y, Deura C, Nakamura S, Suzuki G, Maeda K-I and Tsukamura H. (2013) Microarray Analysis of Perinatal-Estrogen-Induced Changes in Gene Expression Related to Brain Sexual Differentiation in Mice. PLoS ONE 8(11): e79437

Naniwa Y, Nakatsukasa K, Setsuda S, Oishi S, Fujii N, Matsuda F, Uenoyama Y, Tsukamura H, Maeda KI, Ohkura S. (2013) Effects of Full-Length Kisspeptin Administration on Follicular Development in Japanese Black Beef Cows. J Reprod Dev

Nakahara T, Uenoyama Y, Iwase A, Oishi S, Nakamura S, Minabe S, Watanabe Y, Deura C, Noguchi T, Fujii N, Kikkawa F, Maeda KI, Tsukamura H. (2013) Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats. J Reprod Dev 59: 479-484

Suetomi Y, Matsuda F, Uenoyama Y, Maeda KI, Tsukamura H, Ohkura S. (2013) Molecular cloning and identification of the transcriptional regulatory domain of the goat neurokinin B Gene TAC3. J Reprod Dev 59: 463-469

Mostari MP, Ieda N, Deura C, Minabe S, Yamada S, Uenoyama Y, Maeda KI, Tsukamura H. (2013) Dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats. J Reprod Dev 59, 266-272Sakakibara M, Deura C, Minabe S, Iwata Y, Uenoyama Y, Maeda KI, Tsukamura H. (2013) Different critical perinatal periods and hypothalamic sites of oestradiol action in the defeminization of LH surge and lordosis capacity in the rat. J Neuroendocrinol 25:251-259.

Yamada S, Uenoyama Y, Deura C, Minabe S, Naniwa Y, Iwata K, Kawata M, Maeda KI, Tsukamura H. (2012) Oestrogen-dependent suppression of pulsatile luteinizing hormone secretion and Kiss1 mRNA expression in the arcuate nucleus during late lactation in rats. J Neuroendocrinol 24:1234-1242 (doi: 10.1111/j.1365-2826.2012.02330.x.).

Tomikawa J, Uenoyama Y, Ozawa M, Fukanuma T, Takase K, Goto T, Abe H, Ieda N, Minabe S, Deura C, Inoue N, Sanbo M, Tomita K, Hirabayashi M, Tanaka S, Imamura T, Okamura H, Maeda KI, Tsukamura H (2012) Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1114245109

Shimizu Y, Tomikawa J, Hirano K, Nanikawa Y, Akazome Y, Kanda S, Kazeto Y, Okuzawa K, Uenoyama Y, Ohkura S, Tsukamura H, Maeda KI, Gen K, Oka Y, Yamamoto N (2012) Central distribution of kiss2 neurons and peri-pubertal changes in their expression in the brain of male and female red seabream Pagrus major. Gen Comp Endocrinol 175:432-442.

Tomikawa, J., Shimokawa, H., Uesaka, M., Yamamoto, N., Mori, Y., Tsukamura, H., Maeda, K.-I. and Imamura, T. (2011) Single-stranded noncoding RNAs mediate local epigenetic alterations at gene promoters in rat cell lines. J. Biol. Chem. 286, 34788-34799.

Matsuyama, S., Ohkura, S., Mogi, K., Wakabayashi, Y., Mori, Y., Tsukamura, H., Maeda, K.-I., Ichikawa, M. and Okamura, H. (2011). Morphological evidence for direct interaction between kisspeptin and GnRH neurons at the median eminence of the male goat: an immunoelectron microscopic study. Neuroendocrinology, 94, 323-332.

Inoue N, Sasagawa K, Ikai K, Sasaki Y, Tomikawa J, Oishi S, Fujii N, Uenoyama Y, Ohmori Y, Yamamoto N, Hondo E, Maeda K and Tsukamura H (2011) Kisspeptin neurons mediate reflex ovulation in the musk shrew (Suncus murinus). Proc Natl Acad Sci U S A 108:17527-32

Iwata K, Kinoshita M, Susaki N, Uenoyama Y, Tsukamura H and Maeda KI (2011) Central Injection of Ketone Body Suppresses Luteinizing Hormone Release via the Catecholaminergic Pathway in Female Rats. J Reprod Dev 57:379-384.

Iwata K, Kinoshita M, Yamada S, Imamura T, Uenoyama Y, Tsukamura H and Maeda KI (2011) Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats. J Physiol Sci 61:103-113.

Minabe S, Uenoyama Y, Tsukamura H and Maeda KI (2011) Analysis of pulsatile and surge-like luteinizing hormone secretion with frequent blood sampling in female mice. J Reprod Dev 57:660-664.

Noritake KI, Matsuoka T, Ohsawa T, Shimomura K, Sanbuissho A, Uenoyama Y, Maeda KI and Tsukamura H (2011) Involvement of neurokinin receptors in the control of pulsatile luteinizing hormone secretion in rats. J Reprod Dev 57:409-415.

Noritake KI, Suzuki J, Matsuoka T, Makino T, Ohnishi H, Shimomura K, Uenoyama Y, Tsukamura H, Maeda KI and Sanbuissho A (2011) Testicular toxicity induced by a triple neurokinin receptor antagonist in male dogs. Reprod Toxicol 31:440-446.

Uenoyama Y, Inoue N, Pheng V, Homma T, Takase K, Yamada S, Ajiki K, Ichikawa M, Okamura H, Maeda KI and Tsukamura H (2011) Ultrastructural evidence of kisspeptin-gonadotrophin-releasing hormone interaction in the median eminence of female rats: Implication of axo-axonal regulation of GnRH release. J Neuroendocrinol 23:863-870.

 

最近の業績(2011-16)著書・総説

松田二子、前多敬一郎、大蔵 聡、上野山賀久、束村博子(2017)中枢からのアプローチ:新たな神経内分泌メカニズムを利用した繁殖制御 臨床獣医 35 (7), 98–101.

Uenoyama Y, Pheng V, Tsukamura H, Maeda KI. (2016) The roles of kisspeptin revisited: inside and outside the hypothalamus. J Reprod Dev 62: 537–545.

Uenoyama Y, Tomikawa J, Inoue N, Goto T, Minabe S, Ieda N, Nakamura S, Watanabe Y, Ikegami K, Matsuda F, Ohkura S, Maeda KI, Tsukamura H. (2016) Molecular and epigenetic mechanism regulating hypothalamic Kiss1 gene expression in mammals. Neuroendocrinology 103: 640-649.

松田二子、大蔵聡.発明の名称:家畜視床下部繁殖中枢由来不死化神経細胞株.出願番号:特願2015-243719.出願日:2015年12月15日.(出願特許)

前多敬一郎・大石真也・束村博子・上野山賀久・大蔵聡・松田二子(2014)新たな中枢性繁殖制御剤のシーズ:KNDyニューロン MPアグロジャーナル 16,17-21.

Okamura H, Tsukamura H, Ohkura S, Uenoyama Y, Wakabayashi Y, Maeda KI. (2013) Kisspeptin and GnRH Pulse Generation. Adv Exp Med Biol. 2013;784:297-323. doi: 10.1007/978-1-4614-6199-9_14.

井上直子・束村博子・前多敬一郎 (2012) キスペプチンと生殖腺刺激ホルモン放出ホルモン(GnRH)分泌. 臨床神経科学 30, 220-222.

前多敬一郎・束村博子・上野山賀久 (2012) ストレスが繁殖に与える影響〜内分泌学的影響と知見〜 臨床獣医 1, 12-15.

井上直子・上野山賀久・大蔵聡・束村博子・前多敬一郎 (2011) 卵胞発育と成熟(1) 卵胞発育の中枢制御機構. Hormone Frontier in Gynecology 18, 391-394.

上野山賀久・大蔵聡・井上直子・前多敬一郎・束村博子 (2011) 特集 生理活性ペプチド・機能性ペプチド−研究の最先端−キスペプチンによる繁殖機能制御機構. 臨床化学 40, 113-118.