東京大学獣医外科学研究室の業績


2023

  • Co-administration of JQ1, a bromodomain-containing protein 4 inhibitor, enhances the antitumor effect of combretastatin A4, a microtubule inhibitor, while attenuating its cardiotoxicity Orihara  H , Ma  M, Nagashima  Y, Tochinai  R, Sekizawa  S, Kato  D, Shinada  M, Aoki  S, Fujita  N, Nakagawa  T, Tsuru Y , Tatewaki  Y, Mutoh  T, Taki Y, Ryohei Nishimura R, Kuwahara M. Biomed Pharmacother. 2023. 160: 114353
  • mTOR pathway as a potential therapeutic target for cancer stem cells in canine mammary carcinoma. Michishita M, Ochiai K, Nakahira R, Azakami D, Machida Y, Nagashima T, Nakagawa T, Ishiwata T. Front Oncol. 2023. Jan: 110602.
  • Pretreatment with tadalafil attenuates cardiotoxicity induced by combretastatin A4 disodium phosphate in rats. Nagashima Y, Tochinai R,  Sekizawa S,  Kato D, Nakagawa T,  Tsuru Y,  Tatewaki Y, Mutoh T,  Taki Y,  Kuwahara M   Journal of Toxicologic Pathology. 2023. in press.

2022

  • Anti-CCR4 treatment depletes regulatory T cells and leads to clinical activity in a canine model of advanced prostate cancer. Maeda S, Motegi T, Iio A, Kaji K, Goto-Koshino Y, Eto S, Ikeda N, Nakagawa T, Nishimura R, Yonezawa T, Momoi Y. J Immunother Cancer. 2022. 10(2): e003731.
  • Assessment of changes in blood pancreatic lipase activities using FDC-v-LIP in dogs that underwent various surgical procedures. Saeki K, Saeki K, Yokoyama N, Ohno K, Nishimura R. J Vet Emerg Crit Care. 2022. 32(4):471–8.
  • Canine bone marrow peri-adipocyte cells could therapeutically benefit acute spinal cord injury through migration and secretion of hepatocyte growth factor to inflammatory milieu. Chen J, Fujita N, Takeda T, Hanyu W, Takatani H, Nakagawa T, Nishimura R. Exp Anim. 2023. 72(1):19–29.
  • Comprehensive profiling of lipid metabolites in urine of canine patients with liver mass. Kida T , Yamazaki A,  Nakamura T, Kobayashi K , Yoshimoto S , Maeda S, Nakagawa T, Nishimura R, Murata T. J Vet Med Sci. 2022. 84(8):1074-1078.
  • Exploratory study of Superparamagnetic iron oxide dose optimization in breast cancer sentinel lymph node identification using a handheld magnetic probe and iron quantitation. Taruno K, Kuwahata A, Sekino M, Nakagawa T, Kurita T, Enokido K, Nakamura S, Takei H, Kusakabe M. Cancers. 14(6): 1409.
  • Immunohistochemical Analysis using Monoclonal Antibody PMab-269 Against Steller Sea Lion Podoplanin. Li G, Suzuki H, Takei J, Saito M, Goto N, Uchida K, Nakagawa T, Harada H, Tanaka T, Asano T, Kaneko MK, Kato Y. Monoclon Antib Immunodiagn Immunother. 2022. 41(1): 39-44.
  • Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody. Katoh Y, Yaguchi T, Kubo A, Iwata T, Morii K, Kato D, Ohta S, Satomi R, Yamamoto Y, Oyamada Y, Ouchi K , Takahashi S, Ishioka C, Matoba R, Suematsu M , Kawakami Y. J Immunother Cancer. 2022. 10(7): e004616.
  • Long non-coding RNA and transfer RNA-derived small fragments in exosomes are potential biomarkers for canine oral melanoma. Husna AA, Rahman MM, Chen HW, Hasan MN, Nakagawa T, Miura N. Comp Oncol. 2022. 20(3):653–63.
  • Urinary lipid production profile in canine patients with splenic mass. Kida T, Yamazaki A, Nakamura T, Kobayashi K, Yoshimoto S, Maeda S, Nakagawa T, Nishimura R, Murata T. J Vet Med Sci. 2022. 84(11):1480–4.
  • Rapid visualization of mammary gland tumor lesions of dogs using the enzyme-activated fluorogenic probe; γ-glutamyl hydroxymethyl rhodamine green. Hirose Y, Uchida M, Tsuboi M, Nakagawa T, Maeda S, Momoi Y, Kuriki Y, Urano Y, Yonezawa T. J Vet Med Sci. 2022. In press
  • The profile of urinary lipid metabolites in healthy dogs. Kida T, Yamazaki A, Kobayashi K, Nakamura T, Nakagawa T, Nishimura R, Murata T. J Vet Med Sci. 2022. 84(5):644-647.

2021

  • Anorectal Transplantation: The First Long-Term Success in a Canine Model. Araki J, Nishizawa Y, Fujita N, Sato T, Iizuka T, Kamata M, Hatayama N, Yakura T, Hirai S, Tashiro K, Galvão FHF, Nakamura T, Nakagawa M, Naito M. Ann Surg. 2021.
  • A potential bat adenovirus‑based oncolytic virus targeting canine cancers. Matsugo H, Kitamura‑Kobayashi T, Haruhiko Kamiki H, Hiroho Ishida H, Sekine W, Takenaka‑Uema A, Nakagawa T, Murakami S, Horimoto T. Sci Rep. 2021. 11. 16706.
  • Development of Monoclonal Antibody PMab-269 Against California Sea Lion Podoplanin. Tanaka T, Asano T, Sano M, Takei J, Hosono H, Nanamiya R, Nakamura T, Yanaka M, Kaneko MK, Uchida K, Nakagawa T, Kato Y. Monoclon Antib Immunodiagn Immunother. 2021. 40(3):124-133.
  • Detection of indoleamine 2,3-dioxygenase 1–expressing cells in canine normal and tumor tissues. Namiko Ikeda, Daiki Kato*, Masaya Tsuboi, Ryohei Yoshitake, Shotaro Eto, Sho Yoshimoto, Masahiro Shinada, Satoshi Kamoto, Yuko Hashimoto, Yousuke Takahashi, James Chambers, Kazuyuki Uchida, Ryohei Nishimura, Takayuki Nakagawa. J Vet Med Sci. 2021.83(12): 1885-890.
  • Early escitalopram administration as a preemptive treatment strategy against spasticity after contusive spinal cord injury in rats. Ryu Y, Ogata T, Nagao M, Sawada Y, Nishimura R, Fujita N. Sci Rep. 2021. 11(1):7120.
  • ErbB2 copy number gain is associated with adverse outcome in canine mammary carcinoma. Sakai K, Chambers J, Uchida K, Nakagawa T, Nishimura R, Yonezawa T, Maeda S. J Vet Med Sci. 2021. 83(3):370-377.
  • Extracellular vesicles derived from canine mesenchymal stromal cells in serum free culture medium have anti-inflammatory effect on microglial cells. Kuwahara Y, Yoshizaki K, Nishida H, Kamishina H, Maeda S, Takano K, Fujita N, Nishimura R, Jo JI, Tabata Y, Akiyoshi H. Front Vet Sci. 2021. 8:633426.
  • Hypoxic miRNAs expression are different between primary and metastatic melanoma cells. Hino Y, Rahman MM, Lai YC, Husna AA, Chen HW, Hasan MN, Nakagawa T, Miura N. Gene. 2021. 782:145552.
  • Identification of melanoma-specific exosomal miRNAs as the potential biomarker for canine oral melanoma. Husna AA, Rahman MM, Lai YC, Chen HW, Hasan MN, Nakagawa T, Miura N. Pigment Cell Melanoma Res. 2021. 34(6): 1062-1073.
  • Inhibition of vascular adhesion protein-1 enhances the anti-tumor effects of immune checkpoint inhibitors. Kinoshita T, Sayem M, Yaguchi T, Kharma B, Morii K, Kato D, Ohta S, Mashima Y, Asamura H, Kawakami Y. Cancer Science. 2021. 112(4):1390-1401.
  • Involvement of nestin in the progression of canine mammary carcinoma. Yoshimura H, Moriya M, Yoshida A, Yamamoto M, Machida Y, Ochiai K, Michishita M, Nakagawa T, Matsuda Y, Takahashi K, Kamiya S, Ishiwata T. Vet Pathol. 2021. 58(5):994-1003.
  • Optimization of SPIO injection for sentinel lymph node biopsy in a rat model. Peek MCL, Saeki K, Ohashi K, Chikaki S, Baker R, Nakagawa T, Kusakabe M, Douek M, Sekino M. Cancers. 2021. 13(19): 5031
  • Petasin potently inhibits mitochondrial-complex-I-based metabolism supporting tumor growth and metastasis. Heishima K, Sugito N, Soga T, Nishikawa M, Ito Y, Honda R, Kuranaga Y, Sakai H, Ito R, Nakagawa T, Ueda H, Akao Y. J Clin Invest. 2021. 131(17): e139933.
  • Pharmacokinetics and effects on clinical and physiological parameters following a single bolus dose of propofol in common marmosets (Callithrix jacchus). Muta K, Miyabe-Nishiwaki T, Masui K, Yajima I, Iizuka T, Kaneko A, Nishimura R. J Vet Pharmacol Ther. 2021. 44(1):18-27.
  • Scorpion venom peptide effects on inhibiting proliferation and inducing apoptosis in canine mammary gland tumor cell lines. Panja K, Buranapraditkun S, Roytrakul S, Kovitvadhi A, Lertwatcharasarakul P, Nakagawa T, Limmanont C, Jaroensong T. Animals. 2021. 11. 2119.
  • Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes) Miyabe-Nishiwaki T, Kaneko A, Yamanaka A, Maeda N, Suzuki j, Tomonaga M, Matsuzawa T, Muta K, Nishimura R, Yajima I, Eleveld DJ, A. R. Absalom AR, Masui K. 2021. Sci Rep. 11(1):1214.
  • The Expression of Podoplanin in Various Types of Feline Tumor Tissues. Kamoto S+, Shinada M+, Kato D*, Tsuboi M, Yoshimoto S, Yoshitake R, Eto S, Ikeda N, Takahashi Y, Hashimoto Y, Chambers J, Uchida K, Yamada S, Kaneko MK, Nishimura R, Kato Y, Nakagawa T. J Vet Med Sci. 2021. 83(11):1795-1799.
  • The impact of damage-associated molecules released from canine tumor cells on gene expression in macrophages. Eto S, Yanai H, Hangai S, Kato D, Nishimura R, Nakagawa T. Sci Rep. 11(1):8525.

2020

  • Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAFV595E canine urothelial carcinoma. Yoshitake R, Saeki K*, Eto S, Shinada M, Nakano R, Sugiya H, Endo Y, Fujita N, Nishimura R, Nakagawa T. Sci. Rep. 10: 7826. 2020.
  • BRAFV595E mutation associates CCL17 expression and regulatory T cell recruitment in urothelial carcinoma of dogs. Maeda S, Yoshitake R, Eto S, Ikeda N, Nakagawa T, Nishimura R, Goto-Koshino Y, Yonezawa T, Momoi Y. Vet. Pathol. 2020.
  • Computed tomographic lymphangiography via intra-metatarsal pad injection is feasible in dogs with chylothorax. Lee-Shuan Lin, Hsien-Chieh Chiu, Ryohei Nishimura, Reina Fujiwara, Cheng-Shu Chung. Veterinary radiology & ultrasound. 61: 435-443. 2020.
  • Detection of lion podoplanin using the anti-tiger podoplanin monoclonal antibody PMab-231. Kato Y, Takei J, Sano M, Asano T, Sayama Y, Uchida K, Nakagawa T, Kaneko MK. Monoclon Antib. Immunodiagn Immunother. 39: 91-94. 2020.
  • Distillation remnants of shochu, a traditional Japanese liquor, improve pork meat quality by reducing stress. Ano Y, Li JY, Jomoto T, Kurihara D, Nishimura R, Nakayama H, Kuwahara M. Food chemistry. 2020.
  • Evaluation of the safety and proper dosage of lapatinib in dogs. Tanaka Y, Watanabe M, Saeki K, Ong SM, Yoshitake R, Imamura S, Nishimura R, Sugano S, Nakagawa T*. Transl. Regul. Sci. 3: 68-71. 2020.
  • ErbB2 copy number aberration in canine urothelial carcinoma detected by a digital polymerase chain reaction assay. Sakai K, Maeda S, Saeki K, Yoshitake R, Goto-Koshino Y, Nakagawa T, Nishimura R, Yonezawa T, Matsuki N. Vet. Pathol. 57: 56-65. 2020.
  • Evaluation of epithelial and mesenchymal cell markers in canine urinary bladder transitional cell carcinoma. Shinada M, Saeki K*, Yoshitake R, Eto S, Tsuboi M, Chambers JK, Uchida K, Kato D, Yoshimoto S, Kamoto S, Ikeda N, Kinoshita R, Fujita N, Nishimura R, Nakagawa T. Vet. J. 266: 105571. 2020.
  • Foxp3+ Regulatory T Cells Associated With CCL17/CCR4 Expression in Carcinomas of Dogs. Shingo Maeda S, Nakazawa M, Uchida M, Yoshitake R, Nakagawa T, Nishimura R, Miyamoto R, Bonkobara M, Yonezawa T, Momoi Y. Vet. Pathol. In press. 2020.
  • Glypican-1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 antibody therapy. Kato D, Yaguchi T, Iwata T, Katoh Y, Morii K, Tsubota K, Takise Y, Tamiya M, Kamada H, Akiba H, Tsumoto K, Serada S, Naka T, Nishimura R, Nakagawa T, Kawakami Y. eLife. 9:e49392. 2020.
  • Mechanical Regulation Underlies Effects of Exercise on Serotonin-Induced Signaling in the Prefrontal Cortex Neurons. Ryu Y, Maekawa T, Yoshino D, Sakitani N, Takashima A, Inoue T, Suzurikawa J, Toyohara J, Tago T, Makuuchi M, Fujita N, Sawada K, Murase S, Watanave M, Hirai H, Sakai T, Yoshikawa Y, Ogata T, Shinohara M, Nagao M, Sawada Y. iScience. 23: 100874, 2020.
  • Overexpression of human epidermal growth factor receptor 2 in canine primary lung cancer. Yoshimoto S, Kato D*, kamoto S, Yamamoto K, Tsuboi M, Shinada M, Ikeda N, Tanaka Y, Yoshitake R, Eto S, Saeki K, Chambers J, Hashimoto Y, Uchida K, Nishimura R, Nakagawa T. J. Vet. Med. Sci. 82: 804–808. 2020.
  • Overexpression of human epidermal growth factor receptor 2 in canine primary lung cancer. Yoshimoto S, Kato D*, Kamoto S, Yamamoto K, Tsuboi M, Shinada M, Ikeda N, Tanaka Y, Yoshitake R, Eto S, Saeki K, Chambers J, Hashimoto Y, Uchida K, Nishimura R, Nakagawa T. J. Vet. Med. Sci. 2020.
  • Pharmacokinetics and effects on clinical and physiological parameters following a single bolus dose of propofol in common marmosets (Callithrix jacchus). Muta K, Miyabe-Nishiwaki T, Masui K, Yajima I, Iizuka T, Kaneko A, Nishimura R*. Journal of veterinary pharmacology and therapeutics. In press. 2020.
  • Phase I/II Clinical Trial of the Anti-Podoplanin Monoclonal Antibody Therapy in Dogs with Malignant Melanoma. Satoshi K+, Shinada M+, Kato D*, Yoshimoto S, Ikeda N, Tsuboi M, Yoshitake R, Eto S, Hashimoto Y, Takahashi Y, Chambers J, Uchida K, Kaneko MK, Fujita N, Nishimura R, Kato Y, Nakagawa T. Cells. 11: 2529. 2020.
  • PDPN Is Expressed in Various Types of Canine Tumors and Its Silencing Induces Apoptosis and Cell Cycle Arrest in Canine Malignant Melanoma. Shinada M, Kato D*, Kamoto S, Yoshimoto S, Tsuboi M, Yoshitake R, Eto S, Ikeda N, Saeki K, Hashimoto Y, Takahashi Y, Chambers J, Uchida K, Kaneko MK, Fujita N, Nishimura R, Kato Y Nakagawa T. Cells. 9: 1136. 2020.
  • Spindle assembly checkpoint competence in aneuploid canine malignant melanoma cell lines. Endo Y, Saeki K, Watanabe M, Miyajima-Magara M, Igarashi M, Mochizuki M, Nishimura R, Sugano S, Sasaki N, Nakagawa T*. Tissue & cell. 67: 101403-101403. 2020.
  • The inhibitory effect of canine interferon gamma on the growth of canine tumors. Hamamura Y, Nakagawa T, Okuda M, Noguchi S, Igase M, Mizuno T. Res. Vet. Sci. 132: 466-473. 2020.
  • Transcriptome analysis of dog oral melanoma and its oncogenic analogy with human melanoma. Rahman MM, Lai YC, Husna AA, Chen HW, Tanaka Y, Kawaguchi H, Hatai H, Miyoshi N, Nakagawa T, Fukushima R, Miura N. Oncol. Rep. 43: 16-30. 2020.
  • Transcriptome analysis of dog oral melanoma and its oncogenic analogy with human melanoma. Rahman MM, Lai YC, Husna AA, Chen HW, Tanaka Y, Kawaguchi H, Hatai H, Miyoshi N, Nakagawa T, Fukushima R, Miura N. Oncol. Rep. 43: 16-30, 2020.

2019

  • Comparison of the Effect of Growth Factors on Chondrogenesis of Canine Mesenchymal Stem Cells. Endo K, Fujita N, Nakagawa T, Nishimura R. J. Vet. Med. Sci. 81: 1211-1218, 2019.
  • Distance between the skin and the lumbosacral epidural space in dogs. Iseri T, Nishimura R, Nagahama S, Nakagawa T, Fujimoto Y, Sasaki N. Jpn. J. Vet. Res. 67:35-40, 2019.
  • Effect of Fibroblast Growth Factor-2 and Serum on Canine Mesenchymal Stem Cell Chondrogenesis. Endo K, Fujita N, Nakagawa T, Nishimura R. Tissue. Eng. 25: 901-910, 2019
  • ErbB2 copy number aberration in canine urothelial carcinoma detected by a digital polymerase chain reaction assay. Sakai K, Maeda S, Saeki K, Yoshitake R, Goto-Koshino Y, Nakagawa T, Nishimura R, Yonezawa T, Matsuki N. Vet. Pathol. 57: 56-65, 2019.
  • DNA aneuploidy and centrosome amplification in canine tumor cell lines. Endo Y, Watanabe M, Miyajima-Magara N, Igarashi M, Mochizuki M, Nishimura R, Sugano S, Sasaki N, Nakagawa T. Tissue and Cells. 61: 67-71, 2019.
  • Aberrantly expressed snoRNA, snRNA, piRNA and tRFs in canine melanoma. Rahman M, Lai YC, Husna AA, Chen HW, Tanaka Y, Kawaguchi H, Hatai H, Miyoshi N, Nakagawa T, Fukushima R, Miura N. Vet. Comp. Oncol. 2019
  • Efficacy of an anti-cancer strategy targeting SET in canine osteosarcoma. Tsuji S, Nakagawa T, Ohama T, Sato K. J. Vet. Med. Sci. 81: 1424-1430, 2019
  • Micro RNA transcriptome profile in canine oral melanoma. Rahman MM, Lai YC, Ushio N, Husna AA, Chen HW, Tanaka Y, Kawaguchi H, Miyoshi N, Nakagawa T, Fukushima R, Miura N. Int. J. Mol. Sci. 20: 4832, 2019.
  • Metabolite profiling in sphere-forming cells from canine mammary adenocarcinoma cell lines using gas chromatography-mass spectrometry. Michishita M, Saito N, Nozawa S, Furumoto R, Nakagawa T, Sato T, Ochiai K, Azakami D, Katayama K, Nakahira R, Tazaki H, Machida Y, Ishiwata T. J. Vet. Med. Sci. 81: 1238-1248, 2019.
  • Development of canine X-chromosome inactivation pattern analysis for the detection of cell clonality by incorporating the examination of the SLIT and NTRK-like family member 4 (SLITRK4) gene. Tomita A, Mochizuki H, Tsuboi M, Ogura I, Igarashi H, Goto-Koshino Y, Takahashi M, Ohmi A, Tomiyasu H, Ohno K, Nakagawa T, Uchida K, Nishimura R, Tsujimoto H. Res. Vet. Sci. 125: 170-175, 2019.
  • YM155 enhances the cytotoxic activity of etoposide against canine osteosarcoma cells. Ong SM, Saeki K, Kok MK, Nakagawa T*, Nishimura R. J. Vet. Med. Sci. 81: 1182-1190, 2019.
  • Immunohistochemical evaluation of HER2 expression in canine thyroid carcinoma. Yoshimoto S, Kato D, Kamoto S, Yamamoto K, Tsuboi M, Shinada M, Ikeda N, Tanaka Y, Yoshitake R, Eto S, Saeki K, Chambers J, Kinoshita R, Uchida K, Nishimura R, Nakagawa T. Heliyon. 5: e02004, 2019.
  • Detection of HER2 overexpression in canine anal sac gland carcinoma. Yoshimoto S, Kato D, Kamoto S, Yamamoto K, Tsuboi M, Shinada M, Ikeda N, Tanaka Y, Yoshitake R, Eto S, Saeki K, Chambers James, Kinoshita R, Uchida K, Nishimura R, Nakagawa, T. J. Vet. Med. Sci. 81: 1034-1039, 2019.
  • Establishment of a novel experimental model for muscle-invasive bladder cancer by using dog bladder cancer organoid culture. Elbadawy M, Usui T, Mori T, Tsunedomi R, Hazama S, Nabeta R, Uchide T, Fukushima R, Yoshida T, Shibutani M, Tanaka T, Masuda S, Okada R, Ichikawa R, Omatsu T, Mizutani T, Katayama Y, Noguchi S, Iwai S, Nakagawa T, Shinohara Y, Kaneda M, Yamawaki H, Sasaki K. Cancer. Sci. 110: 2806-2821, 2019.
  • Anti-tumor effects of the histone deacetylase inhibitor vorinostat on canine urothelial carcinoma cells. Eto S, Saeki K, Yoshitake R, Yoshimoto S, Shinada M, Ikeda N, Kamoto S, Tanaka Y, Kato D, Maeda S, Tsuboi M, Chambers J, Uchida K, Nishimura R, Nakagawa T. PLoS One. 14: e0218382, 2019.
  • Establishment of a sentinel lymph node metastatic model using immunodeficient swine. Kurihara T, Matsuda S, Nakamura Y, Suzuki S, Fuchimoto D, Onishi A, Saeki K, Nakagawa T, Fujiwara R, Kamata M, Sekino M, Kusakabe M, Hayashida T, Jinno H, Kitagawa Y. Sci. Rep. 9: 7923, 2019.
  • Evaluation of immunohistochemical staining with PMab-38, an anti-dog podoplanin monoclonal antibody, in various canine tumor tissues. Kiname K, Yoshimoto S, Kato D, Tsuboi M, Tanaka Y, Yoshitake R, Eto S, Shinada M, Chambers J, Saeki K, Kinoshita R, Yamada S, Uchida K, K. Kaneko M, Nishimura R, Kato Y, Nakagawa T. Jpn. J. Vet. Res. 2019.
  • Serotonin 3 receptor signaling regulates 5-fluorouracil-mediated apoptosis indirectly via TNF-α production by enhancing serotonin release from enterochromaffin cells. Mikawa S, Kondo M, Kaji N, Mihara T, Yoshitake R, Nakagawa T, Takamoto M, Nishimura R, Shimada S, Ozaki H, Hori M. FASEB J. 33: 1669-1680, 2019.
  • Retrospective Study of Canine Cutaneous Tumors in Japan, 2008-2017. Kok MK, Chambers JK, Tsuboi M, Nishimura R, Tsujimoto H, Uchida K, Nakayama H. J. Vet. Med. Sci. 2019.

2018

  • Comparison of Plasma Propofol Concentration for Apnea, Response to Mechanical Ventilation, and Airway Device Between Endotracheal Tube and Supraglottic Airway Device in Beagles. Iizuka T, Masui K, Kanazawa H, Nishimura R. J. Vet. Med. Sci. 80: 1420-1423, 2018.
  • Anti-tumor effect of lapatinib in canine transitional cell carcinoma cell lines. Sakai K, Maeda S, Saeki K, Nakagawa T, Murakami M, Endo Y, Yonezawa T, Kadosawa T, Mori T, Nishimura R, Matsuki N. Vet. Comp. Oncol. 16: 642-649, 2018.
  • Endogenous Leu332Gln mutation in p53 disrupts the tetramerization ability in a canine mammary gland tumor cell line. Ochiai K, Azakami D, Morimatsu M, Hirama H, Kawakami S, Nakagawa T, Michishita M, Egusa AS, Sasaki T, Watanabe M, Omi T. Oncol. Rep. 40: 488-494, 2018.
  • Sarcomatoid Mesothelioma of Tunica Vaginalis Testis in the Right Scrotum of a Dog. Son NV, Chambers JK, Shiga T, Kishimoto ET, Kikuhara S, Saeki K, Fujiwara R, Tsuboi M, Nishimura R, Uchida K, Nakayama H. J. Vet. Med. Sci. 80: 1125-1128, 2018.
  • Isolation and Characterization of Multipotent Mesenchymal Stem Cells Adhering to Adipocytes in Canine Bone Marrow. Lin HY, Fujita N, Endo K, Morita M, Takeda T, Nakagawa T, Nishimura R. Stem. Cells. Dev. 26: 431-440, 2017.
  • Histopathologic and Immunohistochemistry Findings in Feline Renal Cell Carcinoma. Matsumoto I, Chambers JK, Nibe K, Kinoshita R, Nishimura R, Nakayama H, Uchida K. Vet. Pathol. 55: 663-672, 2018.
  • A pilot study of transplantation of an autologous corneal epithelial cell sheet in a canine model of corneal injury.Nam E, Fujita N, Morita M, Lin HY, Endo K, Nakagawa T, Nishimura R, Tsuzuki K. Jpn. J. Vet. Res. 66:83-92, 2018.
  • Triceps brachii tendon injury in four Pomeranians. Echigo R,Fujita A, Nishimura R, Mocizuki M. J. Vet. Med. Sci. 80: 772-777, 2018.
  • Canine Corneal Epithelial Cells Possess a Sustained Proliferative Capacity and Generate a Spontaneously Derived Cell Line. Morita M, Fujita N, Abe M, Hayashimoto K, Nakagawa T, Nishimura R, Tsuzuki K. Exp. Eye. Res.171: 155-163, 2018.
  • Effects of Treadmill Training Combined With Serotonergic Interventions on Spasticity After Contusive Spinal Cord Injury. Ryu Y, Ogata T, Nagao M, Sawada Y, Nishimura R, Fujita N. J. Neurotrauma. 35: 1358-1366, 2018.

2017

  • Propofol-fentanyl Interaction in Beagles - Apnea, Response to Mechanical Ventilation, Endotracheal Tube, and Tetanic Stimulation. Iizuka T, Masui K, Miyabe-Nishiwaki T, Kanazawa H, Nishimura R. Res. Vet. Sci. 115: 34-42, 2017.
  • The Swimming Test Is Effective for Evaluating Spasticity After Contusive Spinal Cord Injury. Ryu Y, Ogata T, Nagao M, Kitamura T, Morioka K, Ichihara Y, Doi T, Sawada Y, Akai M, Nishimura R, Fujita N. PLoS One. 12: e0171937, 2017.
  • Prospects for personalized combination immunotherapy for solid tumors based on adoptive cell therapies and immune checkpoint blockade therapies. Kato D, Yaguchi T, Iwata T, Morii K, Nakagawa T, Nishimura R, Kawakami Y. Jpn. J. Clin. Immunol. 40: 68-77, 2017
  • Molecular investigation of the direct anti-tumour effects of nonsteroidal anti-inflammatory drugs in a panel of canine cancer cell lines. Yoshitake R, Saeki K, Watanabe M, Nakaoka N, Ong SM, Hanafusa M, Choisunirachon N, Fujita N, Nishimura R, Nakagawa T. Vet. J. 221: 38-47, 2017.
  • Isolation and Characterization of Multipotent Mesenchymal Stem Cells Adhering to Adipocytes in Canine Bone Marrow. Lin HY, Fujita N, Endo K, Morita M, Takeda T, Nakagawa T, Nishimura R. Stem. Cells. Dev. 26: 431-440, 2017.
  • Anti-tumour efficacy of etoposide alone and in combination with piroxicam against canine osteosarcoma in a xenograft model. Ong SM, Saeki K, Kok MK, Tanaka Y, Choisunirachon N, Yoshitake R, Nishimura R, Nakagawa T. Res. Vet. Sci. 113: 130-135, 2017.
  • Establishment of a dog primary prostate cancer organoid using the urine cancer stem cells. Usui T, Sakurai M, Nishikawa S, Umata K, Nemoto Y, Haraguchi T, Itamoto K, Mizuno T, Noguchi S, Mori T, Iwai S, Nakagawa T, Yamawaki H, Ohama T, Sato K. Cancer. Sci. 108: 2383-2392, 2017.
  • Comprehensive DNA microarray expression profiles of tumors in tenascin-C-knockout mice. Matsumoto K, Nakai Y, Hoshino M, Yamazaki K, Takioto Y, Takadera S, Nakagawa T, Nishimura R, Kusakabe M. Biosci. Biotechnol. Biochem. 81: 1926-1936, 2017.
  • The role of SET/I2PP2A in canine mammary tumors. Kake S, Tsuji S, Enjoji S, Hanasaki S, Hayase H, Yabe R, Tanaka Y, Nakagawa T, Liu HP, Chang SC, Usui T, Ohama T, Sato K. Sci Rep 7: 4279, 2017.
  • Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease. Heishima K, Ichikawa Y, Yoshida K, Iwasaki R, Sakai H, Nakagawa T, Tanaka Y, Hoshino Y, Okamura Y, Murakami M, Maruo K, Akao Y, Mori T. Sci. Rep. 7: 2301, 2017.
  • Anti-neoplastic effects of topoisomerase inhibitors in canine mammary carcinoma, melanoma, and osteosarcoma cell lines. Ong SM, Yamamoto H, Saeki K, Tanaka Y, Yoshitake R, Nishimura R, Nakagawa T. Jpn. J. Vet. Res. 65: 17-28, 2017.
  • Functional MRI-based Identification of Brain Regions Activated by Mechanical Noxious Stimulation and Modulatory Effect of Remifentanil in Cats. Nagakubo D, Hamamoto Y, Hasegawa D, Kamata M, Iizuka T, Muta K, Fujita N, Nakagawa T, Nishimura R. Res. Vet. Sci. 114: 444-449, 2017.
  • Desmoplastic Tricholemmoma in a Dog. Kok MK, Chambers JK, Dohata A, Uchida K, Nishimura R, Nakayama H. J. Vet. Med. Sci. 79: 984-987, 2017.
  • Selective Boron Delivery by Intra-Arterial Injection of BSH-WOW Emulsion in Hepatic Cancer Model for Neutron Capture Therapy. Yanagie H, Dewi N, Higashi S, Ikushima I, Seguchi K, Mizumachi R, Murata Y, Morishita Y, Shinohara A, Mikado S, Yasuda N, Fujihara M, Sakurai Y, Mouri K, Yanagawa M, Iizuka T, Suzuki M, Sakurai Y, Masunaga S, Tanaka H, Matsukawa T, Yokoyama K, Fujino T, Ogura K, Nonaka Y, Sugiyama H, Kajiyama T, Yui S, Nishimura R, Ono K, Takamoto S, Nakajima J , Ono M, Eriguchi M, Hasumi K, Takahashi H. Br. J. Radiol. 90: 1074, 2017.
  • Association Between Preoperative Characteristics and Risk of Anaesthesia-Related Death in Dogs in Small-Animal Referral Hospitals in Japan. Itami T, Aida H, Asakawa M, Fujii Y, Iizuka T, Imai A, Iseri T, Ishizuka T, Kakishima K, Kamata M , Miyabe-Nishiwaki T, Nagahama S, Naganobu K, Nishimura R, Okano S, Sano T, Yamashita K, Yamaya Y, Yanagawa M. Vet. Anaesth. Analg. 44: 461-472, 2017.

2016

  • Lin HY, Fujita N, Endo K, Morita M, Takeda T, Nakagawa T, Nishimura R. Isolation and characterization of multipotent mesenchymal stem cells adhering to adipocytes in canine bone marrow. Stem Cells Dev. 2016 Dec 10. [Epub ahead of print]
  • Ong SM, Saeki K, Tanaka Y, Nishimura R, Nakagawa T. Effects of etoposide alone and in combination with piroxicam on canine osteosarcoma cell lines. Vet. J. 218:51-59, 2016.
  • Fujita A, Tsuboi M, Uchida K, Nishimura R. Complex malformations of the urogenital tract in a female dog: Gartner duct cyst, ipsilateral renal agenesis, and ipsilateral hydrometra. Jpn. J. Vet. Res. 64:147-52, 2016.
  • Fujita A, Nishimura R. Surgical stabilization of the atlanto-occipital overlap with atlanto-axial instability in a dog. Jpn. J. Vet. Res. 64:141-5, 2016.
  • Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Ichimura M, Urushisaki Y, Hojo H, Shimohata N, Ohba S, Amaya K, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Repair of segmental radial defects in dogs using tailor-made titanium mesh cages with plates combined with calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel. J. Artif. Organs. 2016 Aug 2. [Epub ahead of print]
  • Shosu K, Sakurai M, Inoue K, Nakagawa T, Sakai H, Morimoto M, Okuda M, Noguchi S, Mizuno T. Programmed Cell Death Ligand 1 Expression in Canine Cancer. In Vivo. 30:195-204, 2016.
  • Michishita, M., Ohtsuka, A., Nakahira, R., Tajima, T., Nakagawa, T., Sasaki, N., Arai, T., Takahashi, K. Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma. J. Vet. Med. Sci. 78:685-689, 2016.
  • Dewi, N., Mi, P., Yanagie, H., Sakurai, Y., Morishita, Y., Yanagawa, M., Nakagawa, T., Shinohara, A., Matsukawa, T., Yokoyama, K., Cabral, H., Suzuki, M., Sakurai, Y., Tanaka, H., Ono, K., Nishiyama, N., Kataoka, K., Takahashi, H. In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent. J. Cancer Res. Clin. Oncol. 142:767-775, 2016.
  • Boller M, Fletcher DJ, Brainard BM, Haskins S, Hopper K, Nadkarni VM, Morley PT, McMichael M, Nishimura R, Robben JH, Rozanski E, Rudloff E, Rush J, Shih A, Smarick S, Tello LH. Utstein-style guidelines on uniform reporting of in-hospital cardiopulmonary resuscitation in dogs and cats. A RECOVER statement. J. Vet. Emerg. Crit. Care. 26(1):11-34, 2016.
  • Chambers JK, Yoshino Y, Fujiwara R, Nishimura R, Nakayama H, Uchida K. Thymic carcinoma with cartilage formation in a dog. J. Comp. Pathol. 154(1):38-41, 2016.
  • Fukushima K, Fujiwara R, Yamamoto K, Kanemoto H, Ohno K, Tsuboi M, Uchida K, Matsuki N, Nishimura R, Tsujimoto H. Characterization of triple-phase computed tomography in dogs with pancreatic insulinoma. J. Vet. Med. Sci. 77(12):1549-53, 2016.

2015

  • Nam, E.R., Fujita, N., Morita, M., Tsuzuki, K., Lin, H.Y., Chung, C.S., Nakagawa, T., Nishimura, R. Comparison of the canine corneal epithelial cell sheets cultivated from limbal stem cells on canine amniotic membrane, atelocollagen gel, and temperature-responsive culture dish. Vet. Ophthalmol. 18:317-325, 2015.
  • Morita, M., Fujita, N., Takahashi, A., Nam, E.R., Yui, S., Chung, C.S., Kawahara, N., Lin, H.Y., Tsuzuki, K., Nakagawa, T., Nishimura, R. Evaluation of ABCG2 and p63 expression in canine cornea and cultivated corneal epithelial cells. Vet. Ophthalmol. 18:59-68, 2015.
  • Iizuka T, Nishimura R. Context-sensitive half-time of fentanyl in dogs. J Vet Med Sci. 77:615-7, 2015.
  • Saeki, K., Watanabe, M., Michishita, M., Tsuboi, M., Sugano, S., Yoshitake, R., Murai, K., Tanaka, Y., Ong, S.M., Saito, T., Matsumoto, K., Fujita, N., Nishimura, R., Nakagawa, T. Phenotypic screening of a library of compounds against metastatic and non-metastatic clones of a canine mammary gland tumour cell line. Vet. J. 205:288-296, 2015. (Award of Andrew Higgins Prize of Veterinary Journal)
  • Saeki, K., Watanabe, M., Tsuboi, M., Sugano, S., Yoshitake, R., Tanaka, Y., Ong, S.M., Saito, T., Matsumoto, K., Fujita, N., Nishimura, R., Nakagawa T. Anti-tumour effect of metformin in canine mammary gland tumour cells. Vet. J. 205:297-304, 2015.
  • Saeki, K., Fujita, A., Fujita, N., Nakagawa, T., Nishimura, R. Total cystectomy and subsequent urinary diversion to the prepuce or vagina in dogs with transitional cell carcinoma of the trigone area: A report of 10 cases (2005-2011). Can. Vet. J. 56:73-80, 2015.
  • Choisunirachon, N., Yoshida, K., Saeki, K., Tanaka, Y., Mochizuki, M., Nishimura, R., Sasaki, N., Nakagawa T. Low-dose cyclophosphamide and piroxicam inhibit growth, migration, and invasion of canine oral malignant melanoma cell line. Thai J. Vet. Med. 45:381-387, 2015.
  • Choisunirachon, N., Jaroensong, T., Yoshida, K., Saeki, K., Mochizuki, M., Nishimura, R., Sasaki, N., Nakagawa T. Effects of low-dose cyclophosphamide with piroxicam on tumor neovascularization in a canine oral malignant melanoma-xenografted mice model. Vet. Comp. Oncol. 13:424-432, 2015.
  • Enjoji, S., Yabe, R., Fujiwara, N., Tsuji, S., Vitek, M.P., Mizuno, T., Nakagawa, T., Usui, T., Ohama, T., Sato, K. The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma. J. Vet. Med. Sci. 77:1451-1456, 2015.
  • Heishima, K., Mori, T., Ichikawa, Y., Sakai, H., Kuranaga, Y., Nakagawa, T., Tanaka, Y., Okamura, Y., Masuzawa, M., Sugito, N., Murakami, M., Yamada, N., Akao, Y., Maruo, K. MicroRNA-214 and microRNA-126 are potential biomarkers for malignant endothelial proliferative diseases. Int. J. Mol. Sci. 16:25377-25391, 2015.
  • Noguchi, S., Mori, T., Nakagawa, T., Itamoto, K., Haraguchi, T., Mizuno, T. DNA methylation contributes to silencing of anti-oncogenic microRNA-203 in human and canine melanoma cells. Melanoma Res. 25:390-398, 2015.
  • Lampreht, U., Kamensek, U., Stimac, M., Sersa, G., Tozon, N., Bosnjak, M., Brozic, A., de Sá Oliveira, G.G., Nakagawa, T., Saeki, K., Cemazar, M. Gene electrotransfer of canine interleukin 12 into canine melanoma cell lines. J. Membr. Biol. 248:909-917, 2015.
  • Thongtharb A, Chambers JK, Uchida K, Watanabe KI, Takahashi A, Mochizuki M, Nishimura R, Nakayama H. Lymphangiosarcoma with systemic metastases in a Japanese domestic cat. J Vet Med Sci. 77(3):371-4, 2015.

2014

  • Yoshida K, Choisunirachon N, Saito T, Matsumoto K, Saeki K, Mochizuki M, Nishimura R, Sasaki N, Nakagawa T. Hepatocyte growth factor-induced up-regulation of Twist drives epithelial-mesenchymal transition in a canine mammary gland tumor cell line. Res Vet Sci. 97:521-526, 2014
  • Choisunirachon N, Lin LS, Tanaka Y, Saeki K, Fujiwara R, Nishimura R, Nakagawa T. Retrospective study of computed tomographic characterization of canine oral malignant melanoma in 24 dogs. Thai J Vet Med. 44:497-503, 2014
  • Choisunirachon N, Tanaka Y, Saeki K, Sasaki N, Nishimura R, Nakagawa T. Proliferative index and microvessel density as potential prognostic markers of canine oral malignant melanomas. Thai J Vet Med. 44:435-443, 2014
  • Yoshida K, Yoshida S, Choisunirachon N, Saito T, Matsumoto K, Saeki K, Mochizuki M, Nishimura R, Sasaki N, Nakagawa T. The relationship between clinicopathological features and expression of epithelial and mesenchymal markers in spontaneous canine mammary gland tumors. J Vet Med Sci. 76:1321-1327, 2014
  • Choi S, Honnami M, Liu IL, Yamamoto K, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Cranioplasty with custom-made artificial bone after resection of multilobular bone tumor in a dog. J Vet Clin. 31:46-50, 2014
  • Choi S, Liu IL, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Implantation of tetrapod-shaped granular artificial bones or β-tricalcium phosphate granules in a canine Large bone-defect model. J Vet Med Sci. 76:229-235, 2014
  • Fukushima K, Kanemoto H, Ohno K, Takahashi M, Fujiwara R, Nishimura R, Tsujimoto H. Computed tomographic morphology and clinical features of extrahepatic portosystemic shunts in 172 dogs in Japan. Vet J. 199:376-381, 2014
  • Saito T, Yoshida K, Matsumoto K, Saeki K, Tanaka Y, Ong SM, Sasaki N, Nishimura R, Nakagawa T. Inflammatory cytokines induce a reduction in E-cadherin expression and morphological changes in MDCK cells. Res Vet Sci. 96:288-291, 2014
  • Michishita M, Ezaki S, Ogihara K, Naya Y, Azakami D, Nakagawa T, Arai T, Takahashi K. Identification of tumor-initiating cells in a canine hepatocellular carcinoma cell line. Res Vet Sci. 96:315-322, 2014
  • Yoshida S, Yoshida K, Jaroensong T, Lee SJ, Kamida A, Saeki K, Fujita N, Nishimura R, Sasaki N, Nakagawa T. Aberrant expressions of sLex and sLea as potential markers for tumor progression of feline mammary gland tumors. J Feline Med Surg. 16:257-264, 2014
  • Sarashina H, Tsubosaka Y, Omori K, Aritake K, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H, Murata T. Opposing Immunomodulatory Roles of Prostaglandin D2 during the Progression of Skin Inflammation. J Immunol. 192:459-65, 2014

2013

  • Iizuka T, Kamata M, Yanagawa M, Nishimura R. Incidence of intraoperative hypotension during isoflurane-fentanyl and propofol-fentanyl anaesthesia in dogs. Vet J. 198:289-291, 2013
  • Michishita M, Otsuka A, Nakahira R, Nakagawa T, Sasaki N, Arai T, Takahashi K. Flow cytometric analysis for detection of tumor-initiating cells in feline mammary carcinoma cell lines. Vet Immunol Immunopathol. 156:73-81, 2013
  • Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel. Biomaterials. 34:9056-9062, 2013
  • Zhang D, Fujiwara R, Iseri T, Nagahama S, Kakishima K, Kamata M, Mochizuki M, Nakagawa T, Sasaki N, Nishimura R. Distribution of Contrast Medium Epidurally Injected at Thoracic and Lumbar Vertebral Segments. J. Vet. Med. Sci. 75:663-666, 2013
  • Nam E, Takahashi A, Fujita N, Tsuzuki K, Nishimura R. Cultivation of corneal epithelial cell sheets on canine amniotic membrane. Vet. Ophthalmol. 16:263-8, 2013
  • 齋藤友睦,松本香織,西村亮平,日下部守昭,中川貴之. 犬乳腺腫瘍における上皮間葉転換と炎症刺激との関連. 乳癌基礎研究. 22:23-26, 2013
  • Chung CS, Fujita N, Kawahara N, Yui S, Nam E, Nishimura R. A Comparison of Neurosphere Differentiation Potential of Canine Bone Marrow-Derived Mesenchymal Stem Cells and Adipose-Derived Mesenchymal Stem Cells. J. Vet. Med. Sci. 75: 879-886, 2013
  • Choi S, Lee J, Igawa K, Liu IL, Honnami M, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Changes in Bone Regeneration by Trehalose Coating and Basic Fibroblast Growth Factor after Implantation of Tailor-Made Bone Implants in Dogs. J. Vet. Med. Sci. 75:721-726, 2013
  • Maniscalco L, Millán Y, Iussich S, Denina M, Sánchez-Céspedes R, Gattino F, Biolatti B, Sasaki N, Nakagawa T, Di Renzo MF, de Las Mulas JM, De Maria R. Activation of mammalian target of rapamycin (mTOR) in triple negative feline mammary carcinomas. BMC Vet Res. 9:80, 2013
  • Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H. Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. Proc. Natl. Acad. Sci. USA. 110:5205-5210, 2013
  • Takeuchi Y, Fujino Y, Watanabe M, Takahashi M, Nakagawa T, Takeuchi A, Bonkobara M, Kobayashi T, Ohno K, Uchida K, Asano K, Nishimura R, Nakayama H, Sugano S, Ohashi Y, Tsujimoto H. Validation of the prognostic value of histopathological grading or c-kit mutation in canine cutaneous mast cell tumours: A retrospective cohort study. Vet. J. 196:492-498, 2013
  • Yoshida K, Saito T, Kamida A, Matsumoto K, Choisunirachon N, Saeki K, Mochizuki M, Sasaki N, Nakagawa T. Transforming growth factor-β transiently induces vimentin expression and invasive capacity in a canine mammary gland tumor cell line. Res. Vet. Sci. 94:539-541, 2013

2012

  • Jaroensong T, Endo Y, Lee SJ, Kamida A, Mochizuki M, Nishimura R, Sasaki N and Nakagawa T. Effects of transplantation sites on tumor growth, pulmonary metastasis and ezrin expression of canine osteosarcoma cell lines in nude mice. Vet. Comp. Oncol. 10:274-282, 2012
  • Michishita, M., Akiyoshi, R., Suemizu, H., Nakagawa, T., Sasaki, N., Takemitsu, H., Arai, T., Takahashi, K. Aldehyde dehydrogenase activity in cancer stem cells from canine mammary carcinoma cell lines. Vet. J. 193:508-513, 2012
  • Murai, K., Nakagawa, T., Endo, Y., Kamida, A., Yoshida, K., Mochizuki, M., Nishimura, R., Sasaki,N. Establishment of a pair of novel cloned tumour cell lines with or without metastatic potential from canine mammary adenocarcinoma. Res. Vet. Sci. 93:468-472, 2012
  • Mkaouar L, Nakagawa T, Endo Y, Jun HX, Lee SJ, Jaroensong T, Mochizuki M, Uchida K, Nakayama H and Sasaki N. Relationship between NF-κB expression and malignancy of canine mammary gland tumor tissues. J. Vet. Med. Sci. 74:713-718, 2012
  • Saeki, K., Endo, Y., Uchida, K., Nishimura, R., Sasaki, N.,Nakagawa, T. Significance of tumor infiltrating immune cells in spontaneous canine mammary gland tumor: 140 cases. J. Vet. Med. Sci. 74:227-230, 2012
  • Kamata M, Nagahama S, Kakishima K, Sasaki N, Nishimura R. Comparison of behavioral effects of morphine and fentanyl in dogs and cats. J. Vet. Med. Sci. 74:231-234, 2012
  • Kamata M, King JN, Seewald W, Sakakibara N, Yamashita K, Nishimura R. Comparison of injectable robenacoxib versus meloxicam for peri-operative use in cats: Results of a randomised clinical trial. Vet. J. 193:114-118, 2012
  • Tei M, Uchida K, Chambers JK, Harada H, Takahashi M, Nishimura R, Watanabe M, Nakayama H. Mammary lipid-rich carcinoma with extensive amyloid deposition in a dog. J. Vet. Med. Sci. 74:809-811, 2012
  • Fukushima K, Kanemoto H, Ohno K, Takahashi M, Nakashima K, Fujino Y, Uchida K, Fujiwara R, Nishimura R, Tsujimoto H. CT characteristic of primary hepatic mass lesions in dogs. Vet. Radiol. Ultrasound. 53:252-257, 2012
  • Okawa, T., Kurio, Y., Morimoto, M., Hayashi, T., Nakagawa, T., Sasaki, N., Okuda, M., Mizuno, T. Calreticulin expression in neoplastic versus normal dog mammary glands: A cDNA subtraction-based study. Res. Vet. Sci. 92:80-91, 2012
  • Ito, S., Shimohata, N., Iwanaga, S., Ito, W., Ohba, M., Mochizuki, M., Nakagawa. T., Suzuki, S., Sasaki, N., Kochima, I., Chung, U-I. Prevention of intubation-induced mucosal damage using a tube coated with 2-methacryloyloxyethyl phosphorylcholine polymer. Eur. J. Anaesthesiol. 29:100-104, 2012
  • Maniscalco, L., Iussich, S., Martin de las Mulas, J., Millan, Y., Biolatti, B., Sasaki, N., Nakagawa, T., De Maria, R. Activation of AKT in feline mammary carcinoma : A new prognostic factor for feline mammary tumours. Vet. J. 191:65-71, 2012
  • Fukushima K, Kanemoto H, Ohno K, Takahashi M, Nakashima K, Fujino Y, Uchida K, Fujiwara R, Nishimura R, Tsujimoto H. CT characteristic of primary hepatic mass lesions in dogs. Vet. Radiol. Ultrasound. 53:252-257, 2012
  • Ohmi A, Tsukamoto A, Ohno K, Uchida K, Nishimura R, Fukushima K, Takahashi M, Nakashima K, Fujino Y, Tsujimoto H. A retrospective study of inflammatory colorectal polyps in miniature dachshunds. J. Vet. Med. Sci. 74:59-64, 2012
  • Noguchi, S., Mori, T., Hoshino, Y., Yamada, N., Nakagawa, T., Sasaki, N., Akao, Y., Maruo, K. Comparative study of anti-oncogenic microRNA-145 in canine and human malignant melanoma. J. Vet. Med. Sci. 74:1-8, 2012
  • Takeuchi, Y., Fujino, Y., Fukushima, K., Watanabe, M., Nakagawa, T., Ohno, K., Sasaki, N., Sugano, S., Tsujimoto, H. Biological effect of tyrosine kinase inhibitors on three canine mast cell tumor cell lines with various KIT statuses. J. Vet. Pharmacol. Ther. 35:97-104, 2012

2011

  • Choi, S., Lee, J., Igawa, K., Suzuki, S., Mochizuki, M., Nishimura, R., Chung, U., Sasaki, N. Effect of trehalose coating on basic fibroblast growth factor release from tailor-made bone implants. J. Vet. Med. Sci. 73:1547-1552, 2011
  • Fujino, H., Lee, S., Suzuki, S., Chung, UI, Mochizuki, M., Nishimura, R., Sasaki, N. Trehalose may prevent postsurgical adhesion in a rabbit model of hysterectomy. J. Vet. Med. Sci. 73:931-935, 2011
  • Yui S, Ito D, Fujita N, Nishimura R. Effects of fibroblasts derived from olfactory bulb and from nasal olfactory mucosa on proliferation of olfactory ensheathing cells harvested from olfactory bulb. J. Vet. Med. Sci. 73:133-7, 2011
  • Zhang, D., Nishimura, R., Nagahama, S., Iseri, T., Mochizuki, M., Nakanagawa, T., Sasaki, N. Comparison of feasibility and and safety of epidural catheterization between cranial and caudal lumber vertebral segments in dogs. J. Vet. Med. Sci. 73:1573-1577, 2011
  • Mkaouar, L., Endo, Y., Mochiozuki, M., Nishimura, R., Sasaki, N., Nakagawa, T. Effects of NF-kappaB expression and its inhibition on canine mammary cancer cell lines in an immunodeficiet mice model. J. Vet. Med. Sci. 73:1539-1546, 2011
  • Kanaya, N., Yazawa, M., Goto-Kochino, Y., Mochizuki, M., Nishimura, R., Ohno, K., Sasaki, N., Tsujimoto, H. Anti-tumor effect of adenoviral vector-mediated p53 gene transfer on the growth of canine osteosarcoma. J. Vet. Med. Sci. 73:877-883, 2011
  • Murata, T., Aritake, K., Matsumoto, S., Kamauchi, S., Nakagawa, T., Hoir, M., Momotani, E., Urade, Y., Ozaki H. Prostagladin D2 is a mast cell-derived anti-angiogenic factor in lung carcinoma. Proc. Natl. Acad. Sci. USA. 108:19802-19807, 2011
  • Yanagie H, Kumada H, Nakamura T, Higashi S, Ikushima I, Morishita Y, Shinohara A, Fijihara M, Suzuki M, Sakurai Y, Sugiyama H, Kajiyama T, Nishimura R, Ono K, Nakajima J, Ono M, Eriguchi M, Takahashi H. Feasibility evaluation of neutron capture therapy for hepatocellular carcinoma using selective enhancement of boron accumulation in tumour with intra-arterial administration of boron-entrapped water-in-oil-in-water emulsion. Appl. Radiat. Isot. 69:1854-7, 2011
  • Takeuchi, Y., Fujino, Y., Watanabe, M., Nakagawa, T., Ohno, K., Sasaki, N., Sugano, S., Tsujimoto, H. Screening of therapeutic targets for canine mast cell tumors from variety of kinase molecules. J. Vet. Med. Sci. 73:1295-1302, 2011
  • Michishita, M., Akiyoshi, R., Yoshimura, H., Katsumoto, T., Ichikawa, H., Ohkusu-Tsukada, K., Nakagawa, T., Sasaki, N., Takahashi, K. Chracterization of spheres derived from canine mammary gland adenocarcinoma cell lines. Res. Vet. Sci. 91:251-253, 2011

受賞歴

  • 2022年 長久保大  日本獣医麻酔外科学会 優秀発表賞(麻酔疼痛部門)
  • 2021年 加藤大貴  日本獣医学会 獣医学奨励賞
  • 2020年 羽生 航  Vets Talk ベストプレゼンター賞
  • 2020年 加藤大貴  井上科学振興財団 井上研究奨励賞
  • 2020年 遠藤健太郎 日本獣医学会 JVMS優秀論文賞
  • 2020年 高橋洋介  日本獣医麻酔外科学会 優秀発表賞(軟部組織部門)
  • 2019年 飯塚智也  日本獣医麻酔外科学会 優秀発表賞(麻酔疼痛部門)
  • 2019年 平山琢朗  日本獣医麻酔外科学会 優秀発表賞(麻酔疼痛部門)
  • 2019年 遠藤健太郎 東京大学 獣医学専攻長賞
  • 2019年 武田 妙  アジア獣医学会 優秀発表賞
  • 2017年 菊原章太郎 日本獣医麻酔外科学会 優秀発表賞
  • 2016年 佐伯亘平  日本獣医内科学アカデミー 優秀発表賞(研究部門)
  • 2016年 佐伯亘平  Veterinary Journal誌 Andrew Higgins Prize
  • 2016年 長久保大  日本獣医麻酔外科学会 優秀発表賞(麻酔疼痛部門)
  • 2016年 牟田佳那子 日本獣医麻酔外科学会 優秀発表賞(麻酔疼痛部門)
  • 2016年 飯塚智也  日本獣医麻酔外科学会 優秀発表賞
  • 2016年 加藤大貴  日本臨床免疫学会 優秀発表賞
  • 2016年 西村亮平  (公)日本動物病院協会 JAHA学術功労賞
  • 2014年 木ノ下怜平 日本獣医麻酔外科学会 優秀発表賞
  • 2014年 森田莉彩  日本獣医麻酔外科学会 優秀発表賞
  • 2014年 佐伯亘平  東京大学生命科学シンポジウム ポスター賞