業 績 (2011~ )  

2016
Anti-neoplastic effects of topoisomerase inhibitors in canine mammary carcinoma, melanoma, and osteosarcoma cell lines.
Ong SM, Saeki K, Tanaka Y, Nishimura R, Nakagawa T.
Jpn. J. Vet. Res. in press

Lin HY, Fujita N, Endo K, Morita M, Takeda T, Nakagawa T, Nishimura R.
Isolation and characterization of multipotent mesenchymal stem cells adhering to adipocytes in canine bone marrow.
Stem Cells Dev. 2016 Dec 10. [Epub ahead of print]

Ong SM, Saeki K, Tanaka Y, Nishimura R, Nakagawa T.
Effects of etoposide alone and in combination with piroxicam on canine osteosarcoma cell lines.
Vet. J. 218:51-59, 2016.

Fujita A, Tsuboi M, Uchida K, Nishimura R.
Complex malformations of the urogenital tract in a female dog: Gartner duct cyst, ipsilateral renal agenesis, and ipsilateral hydrometra.
Jpn. J. Vet. Res. 64:147-52, 2016.

Fujita A, Nishimura R.
Surgical stabilization of the atlanto-occipital overlap with atlanto-axial instability in a dog.
Jpn. J. Vet. Res. 64:141-5, 2016.

Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Ichimura M, Urushisaki Y, Hojo H, Shimohata N, Ohba S, Amaya K, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M.
Repair of segmental radial defects in dogs using tailor-made titanium mesh cages with plates combined with calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel.
J. Artif. Organs. 2016 Aug 2. [Epub ahead of print]

Shosu K, Sakurai M, Inoue K, Nakagawa T, Sakai H, Morimoto M, Okuda M, Noguchi S, Mizuno T.
Programmed Cell Death Ligand 1 Expression in Canine Cancer.
In Vivo. 30:195-204, 2016.

Michishita, M., Ohtsuka, A., Nakahira, R., Tajima, T., Nakagawa, T., Sasaki, N., Arai, T., Takahashi, K.
Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma.
J. Vet. Med. Sci. 78:685-689, 2016.

Dewi, N., Mi, P., Yanagie, H., Sakurai, Y., Morishita, Y., Yanagawa, M., Nakagawa, T., Shinohara, A., Matsukawa, T., Yokoyama, K., Cabral, H., Suzuki, M., Sakurai, Y., Tanaka, H., Ono, K., Nishiyama, N., Kataoka, K., Takahashi, H.
In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent.
J. Cancer Res. Clin. Oncol. 142:767-775, 2016.

Boller M, Fletcher DJ, Brainard BM, Haskins S, Hopper K, Nadkarni VM, Morley PT, McMichael M, Nishimura R, Robben JH, Rozanski E, Rudloff E, Rush J, Shih A, Smarick S, Tello LH.
Utstein-style guidelines on uniform reporting of in-hospital cardiopulmonary resuscitation in dogs and cats. A RECOVER statement.
J. Vet. Emerg. Crit. Care. 26(1):11-34, 2016.

Chambers JK, Yoshino Y, Fujiwara R, Nishimura R, Nakayama H, Uchida K.
Thymic carcinoma with cartilage formation in a dog.
J. Comp. Pathol. 154(1):38-41, 2016.

Fukushima K, Fujiwara R, Yamamoto K, Kanemoto H, Ohno K, Tsuboi M, Uchida K, Matsuki N, Nishimura R, Tsujimoto H.
Characterization of triple-phase computed tomography in dogs with pancreatic insulinoma.
J. Vet. Med. Sci. 77(12):1549-53, 2016.

2015
Nam, E.R., Fujita, N., Morita, M., Tsuzuki, K., Lin, H.Y., Chung, C.S., Nakagawa, T., Nishimura, R.
Comparison of the canine corneal epithelial cell sheets cultivated from limbal stem cells on canine amniotic membrane, atelocollagen gel, and temperature-responsive culture dish.
Vet. Ophthalmol. 18:317-325, 2015.

Morita, M., Fujita, N., Takahashi, A., Nam, E.R., Yui, S., Chung, C.S., Kawahara, N., Lin, H.Y., Tsuzuki, K., Nakagawa, T., Nishimura, R.
Evaluation of ABCG2 and p63 expression in canine cornea and cultivated corneal epithelial cells.
Vet. Ophthalmol. 18:59-68, 2015.

Iizuka T, Nishimura R.
Context-sensitive half-time of fentanyl in dogs.
J Vet Med Sci. 77:615-7, 2015.

Saeki, K., Watanabe, M., Michishita, M., Tsuboi, M., Sugano, S., Yoshitake, R., Murai, K., Tanaka, Y., Ong, S.M., Saito, T., Matsumoto, K., Fujita, N., Nishimura, R., Nakagawa, T.
Phenotypic screening of a library of compounds against metastatic and non-metastatic clones of a canine mammary gland tumour cell line.
Vet. J. 205:288-296, 2015.
(Award of Andrew Higgins Prize of Veterinary Journal)

Saeki, K., Watanabe, M., Tsuboi, M., Sugano, S., Yoshitake, R., Tanaka, Y., Ong, S.M., Saito, T., Matsumoto, K., Fujita, N., Nishimura, R., Nakagawa T.
Anti-tumour effect of metformin in canine mammary gland tumour cells.
Vet. J. 205:297-304, 2015.

Saeki, K., Fujita, A., Fujita, N., Nakagawa, T., Nishimura, R.
Total cystectomy and subsequent urinary diversion to the prepuce or vagina in dogs with transitional cell carcinoma of the trigone area: A report of 10 cases (2005-2011).
Can. Vet. J. 56:73-80, 2015.

Choisunirachon, N., Yoshida, K., Saeki, K., Tanaka, Y., Mochizuki, M., Nishimura, R., Sasaki, N., Nakagawa T.
Low-dose cyclophosphamide and piroxicam inhibit growth, migration, and invasion of canine oral malignant melanoma cell line.
Thai J. Vet. Med. 45:381-387, 2015.

Choisunirachon, N., Jaroensong, T., Yoshida, K., Saeki, K., Mochizuki, M., Nishimura, R., Sasaki, N., Nakagawa T.
Effects of low-dose cyclophosphamide with piroxicam on tumor neovascularization in a canine oral malignant melanoma-xenografted mice model.
Vet. Comp. Oncol. 13:424-432, 2015.

Enjoji, S., Yabe, R., Fujiwara, N., Tsuji, S., Vitek, M.P., Mizuno, T., Nakagawa, T., Usui, T., Ohama, T., Sato, K.
The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma.
J. Vet. Med. Sci. 77:1451-1456, 2015.

Heishima, K., Mori, T., Ichikawa, Y., Sakai, H., Kuranaga, Y., Nakagawa, T., Tanaka, Y., Okamura, Y., Masuzawa, M., Sugito, N., Murakami, M., Yamada, N., Akao, Y., Maruo, K.
MicroRNA-214 and microRNA-126 are potential biomarkers for malignant endothelial proliferative diseases.
Int. J. Mol. Sci. 16:25377-25391, 2015.

Noguchi, S., Mori, T., Nakagawa, T., Itamoto, K., Haraguchi, T., Mizuno, T.
DNA methylation contributes to silencing of anti-oncogenic microRNA-203 in human and canine melanoma cells.
Melanoma Res. 25:390-398, 2015.

Lampreht, U., Kamensek, U., Stimac, M., Sersa, G., Tozon, N., Bosnjak, M., Brozic, A., de Sá Oliveira, G.G., Nakagawa, T., Saeki, K., Cemazar, M.
Gene electrotransfer of canine interleukin 12 into canine melanoma cell lines.
J. Membr. Biol. 248:909-917, 2015.

Thongtharb A, Chambers JK, Uchida K, Watanabe KI, Takahashi A, Mochizuki M, Nishimura R, Nakayama H.
Lymphangiosarcoma with systemic metastases in a Japanese domestic cat.
J Vet Med Sci. 77(3):371-4, 2015.

2014
Yoshida K, Choisunirachon N, Saito T, Matsumoto K, Saeki K, Mochizuki M, Nishimura R, Sasaki N, Nakagawa T.
Hepatocyte growth factor-induced up-regulation of Twist drives epithelial-mesenchymal transition in a canine mammary gland tumor cell line.
Res Vet Sci. 97:521-526, 2014

Choisunirachon N, Lin LS, Tanaka Y, Saeki K, Fujiwara R, Nishimura R, Nakagawa T.
Retrospective study of computed tomographic characterization of canine oral malignant melanoma in 24 dogs.
Thai J Vet Med. 44:497-503, 2014

Choisunirachon N, Tanaka Y, Saeki K, Sasaki N, Nishimura R, Nakagawa T.
Proliferative index and microvessel density as potential prognostic markers of canine oral malignant melanomas.
Thai J Vet Med. 44:435-443, 2014

Yoshida K, Yoshida S, Choisunirachon N, Saito T, Matsumoto K, Saeki K, Mochizuki M, Nishimura R, Sasaki N, Nakagawa T.
The relationship between clinicopathological features and expression of epithelial and mesenchymal markers in spontaneous canine mammary gland tumors.
J Vet Med Sci. 76:1321-1327, 2014

Choi S, Honnami M, Liu IL, Yamamoto K, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M.
Cranioplasty with custom-made artificial bone after resection of multilobular bone tumor in a dog.
J Vet Clin. 31:46-50, 2014

Choi S, Liu IL, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M.
Implantation of tetrapod-shaped granular artificial bones or β-tricalcium phosphate granules in a canine Large bone-defect model.
J Vet Med Sci. 76:229-235, 2014

Fukushima K, Kanemoto H, Ohno K, Takahashi M, Fujiwara R, Nishimura R, Tsujimoto H.
Computed tomographic morphology and clinical features of extrahepatic portosystemic shunts in 172 dogs in Japan.
Vet J. 199:376-381, 2014

Saito T, Yoshida K, Matsumoto K, Saeki K, Tanaka Y, Ong SM, Sasaki N, Nishimura R, Nakagawa T.
Inflammatory cytokines induce a reduction in E-cadherin expression and morphological changes in MDCK cells.
Res Vet Sci. 96:288-291, 2014

Michishita M, Ezaki S, Ogihara K, Naya Y, Azakami D, Nakagawa T, Arai T, Takahashi K.
Identification of tumor-initiating cells in a canine hepatocellular carcinoma cell line.
Res Vet Sci. 96:315-322, 2014

Yoshida S, Yoshida K, Jaroensong T, Lee SJ, Kamida A, Saeki K, Fujita N, Nishimura R, Sasaki N, Nakagawa T.
Aberrant expressions of sLex and sLea as potential markers for tumor progression of feline mammary gland tumors.
J Feline Med Surg. 16:257-264, 2014

Sarashina H, Tsubosaka Y, Omori K, Aritake K, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H, Murata T.
Opposing Immunomodulatory Roles of Prostaglandin D2 during the Progression of Skin Inflammation.
J Immunol. 192:459-65, 2014

2013
Iizuka T, Kamata M, Yanagawa M, Nishimura R.
Incidence of intraoperative hypotension during isoflurane-fentanyl and propofol-fentanyl anaesthesia in dogs.
Vet J. 198:289-291, 2013

Michishita M, Otsuka A, Nakahira R, Nakagawa T, Sasaki N, Arai T, Takahashi K.
Flow cytometric analysis for detection of tumor-initiating cells in feline mammary carcinoma cell lines.
Vet Immunol Immunopathol. 156:73-81, 2013

Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M.
Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel.
Biomaterials. 34:9056-9062, 2013

Zhang D, Fujiwara R, Iseri T, Nagahama S, Kakishima K, Kamata M, Mochizuki M, Nakagawa T, Sasaki N, Nishimura R.
Distribution of Contrast Medium Epidurally Injected at Thoracic and Lumbar Vertebral Segments.
J. Vet. Med. Sci. 75:663-666, 2013

Nam E, Takahashi A, Fujita N, Tsuzuki K, Nishimura R.
Cultivation of corneal epithelial cell sheets on canine amniotic membrane.
Vet. Ophthalmol. 16:263-8, 2013

齋藤友睦,松本香織,西村亮平,日下部守昭,中川貴之.
犬乳腺腫瘍における上皮間葉転換と炎症刺激との関連.
乳癌基礎研究. 22:23-26, 2013

Chung CS, Fujita N, Kawahara N, Yui S, Nam E, Nishimura R.
A Comparison of Neurosphere Differentiation Potential of Canine Bone Marrow-Derived Mesenchymal Stem Cells and Adipose-Derived Mesenchymal Stem Cells.
J. Vet. Med. Sci. 75: 879-886, 2013

Choi S, Lee J, Igawa K, Liu IL, Honnami M, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M.
Changes in Bone Regeneration by Trehalose Coating and Basic Fibroblast Growth Factor after Implantation of Tailor-Made Bone Implants in Dogs.
J. Vet. Med. Sci. 75:721-726, 2013

Maniscalco L, Millán Y, Iussich S, Denina M, Sánchez-Céspedes R, Gattino F, Biolatti B, Sasaki N, Nakagawa T, Di Renzo MF, de Las Mulas JM, De Maria R.
Activation of mammalian target of rapamycin (mTOR) in triple negative feline mammary carcinomas.
BMC Vet Res. 9:80, 2013

Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H.
Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement.
Proc. Natl. Acad. Sci. USA. 110:5205-5210, 2013

Takeuchi Y, Fujino Y, Watanabe M, Takahashi M, Nakagawa T, Takeuchi A, Bonkobara M, Kobayashi T, Ohno K, Uchida K, Asano K, Nishimura R, Nakayama H, Sugano S, Ohashi Y, Tsujimoto H.
Validation of the prognostic value of histopathological grading or c-kit mutation in canine cutaneous mast cell tumours: A retrospective cohort study.
Vet. J. 196:492-498, 2013

Yoshida K, Saito T, Kamida A, Matsumoto K, Choisunirachon N, Saeki K, Mochizuki M, Sasaki N, Nakagawa T.
Transforming growth factor-β transiently induces vimentin expression and invasive capacity in a canine mammary gland tumor cell line.
Res. Vet. Sci. 94:539-541, 2013

2012
Jaroensong T, Endo Y, Lee SJ, Kamida A, Mochizuki M, Nishimura R, Sasaki N and Nakagawa T.
Effects of transplantation sites on tumor growth, pulmonary metastasis and ezrin expression of canine osteosarcoma cell lines in nude mice.
Vet. Comp. Oncol. 10:274-282, 2012

Michishita, M., Akiyoshi, R., Suemizu, H., Nakagawa, T., Sasaki, N., Takemitsu, H., Arai, T., Takahashi, K.
Aldehyde dehydrogenase activity in cancer stem cells from canine mammary carcinoma cell lines.
Vet. J. 193:508-513, 2012

Murai, K., Nakagawa, T., Endo, Y., Kamida, A., Yoshida, K., Mochizuki, M., Nishimura, R., Sasaki,N.
Establishment of a pair of novel cloned tumour cell lines with or without metastatic potential from canine mammary adenocarcinoma.
Res. Vet. Sci. 93:468-472, 2012

Mkaouar L, Nakagawa T, Endo Y, Jun HX, Lee SJ, Jaroensong T, Mochizuki M, Uchida K, Nakayama H and Sasaki N.
Relationship between NF-κB expression and malignancy of canine mammary gland tumor tissues.
J. Vet. Med. Sci. 74:713-718, 2012

Saeki, K., Endo, Y., Uchida, K., Nishimura, R., Sasaki, N.,Nakagawa, T.
Significance of tumor infiltrating immune cells in spontaneous canine mammary gland tumor: 140 cases.
J. Vet. Med. Sci. 74:227-230, 2012

Kamata M, Nagahama S, Kakishima K, Sasaki N, Nishimura R.
Comparison of behavioral effects of morphine and fentanyl in dogs and cats.
J. Vet. Med. Sci. 74:231-234, 2012

Kamata M, King JN, Seewald W, Sakakibara N, Yamashita K, Nishimura R.
Comparison of injectable robenacoxib versus meloxicam for peri-operative use in cats: Results of a randomised clinical trial.
Vet. J. 193:114-118, 2012

Tei M, Uchida K, Chambers JK, Harada H, Takahashi M, Nishimura R, Watanabe M, Nakayama H.
Mammary lipid-rich carcinoma with extensive amyloid deposition in a dog.
J. Vet. Med. Sci. 74:809-811, 2012

Fukushima K, Kanemoto H, Ohno K, Takahashi M, Nakashima K, Fujino Y, Uchida K, Fujiwara R, Nishimura R, Tsujimoto H.
CT characteristic of primary hepatic mass lesions in dogs.
Vet. Radiol. Ultrasound. 53:252-257, 2012

Okawa, T., Kurio, Y., Morimoto, M., Hayashi, T., Nakagawa, T., Sasaki, N., Okuda, M., Mizuno, T.
Calreticulin expression in neoplastic versus normal dog mammary glands: A cDNA subtraction-based study.
Res. Vet. Sci. 92:80-91, 2012

Ito, S., Shimohata, N., Iwanaga, S., Ito, W., Ohba, M., Mochizuki, M., Nakagawa. T., Suzuki, S., Sasaki, N., Kochima, I., Chung, U-I.
Prevention of intubation-induced mucosal damage using a tube coated with 2-methacryloyloxyethyl phosphorylcholine polymer.
Eur. J. Anaesthesiol. 29:100-104, 2012

Maniscalco, L., Iussich, S., Martin de las Mulas, J., Millan, Y., Biolatti, B., Sasaki, N., Nakagawa, T., De Maria, R.
Activation of AKT in feline mammary carcinoma : A new prognostic factor for feline mammary tumours.
Vet. J. 191:65-71, 2012

Fukushima K, Kanemoto H, Ohno K, Takahashi M, Nakashima K, Fujino Y, Uchida K, Fujiwara R, Nishimura R, Tsujimoto H.
CT characteristic of primary hepatic mass lesions in dogs.
Vet. Radiol. Ultrasound. 53:252-257, 2012

Ohmi A, Tsukamoto A, Ohno K, Uchida K, Nishimura R, Fukushima K, Takahashi M, Nakashima K, Fujino Y, Tsujimoto H.
A retrospective study of inflammatory colorectal polyps in miniature dachshunds.
J. Vet. Med. Sci. 74:59-64, 2012

Noguchi, S., Mori, T., Hoshino, Y., Yamada, N., Nakagawa, T., Sasaki, N., Akao, Y., Maruo, K.
Comparative study of anti-oncogenic microRNA-145 in canine and human malignant melanoma.
J. Vet. Med. Sci. 74:1-8, 2012

Takeuchi, Y., Fujino, Y., Fukushima, K., Watanabe, M., Nakagawa, T., Ohno, K., Sasaki, N., Sugano, S., Tsujimoto, H.
Biological effect of tyrosine kinase inhibitors on three canine mast cell tumor cell lines with various KIT statuses.
J. Vet. Pharmacol. Ther. 35:97-104, 2012

2011
Choi, S., Lee, J., Igawa, K., Suzuki, S., Mochizuki, M., Nishimura, R., Chung, U., Sasaki, N.
Effect of trehalose coating on basic fibroblast growth factor release from tailor-made bone implants.
J. Vet. Med. Sci. 73:1547-1552, 2011

Fujino, H., Lee, S., Suzuki, S., Chung, UI, Mochizuki, M., Nishimura, R., Sasaki, N.
Trehalose may prevent postsurgical adhesion in a rabbit model of hysterectomy.
J. Vet. Med. Sci. 73:931-935, 2011

Yui S, Ito D, Fujita N, Nishimura R.
Effects of fibroblasts derived from olfactory bulb and from nasal olfactory mucosa on proliferation of olfactory ensheathing cells harvested from olfactory bulb.
J. Vet. Med. Sci. 73:133-7, 2011

Zhang, D., Nishimura, R., Nagahama, S., Iseri, T., Mochizuki, M., Nakanagawa, T., Sasaki, N.
Comparison of feasibility and and safety of epidural catheterization between cranial and caudal lumber vertebral segments in dogs.
J. Vet. Med. Sci. 73:1573-1577, 2011

Mkaouar, L., Endo, Y., Mochiozuki, M., Nishimura, R., Sasaki, N., Nakagawa, T.
Effects of NF-kappaB expression and its inhibition on canine mammary cancer cell lines in an immunodeficiet mice model.
J. Vet. Med. Sci. 73:1539-1546, 2011

Kanaya, N., Yazawa, M., Goto-Kochino, Y., Mochizuki, M., Nishimura, R., Ohno, K., Sasaki, N., Tsujimoto, H.
Anti-tumor effect of adenoviral vector-mediated p53 gene transfer on the growth of canine
osteosarcoma.
J. Vet. Med. Sci. 73:877-883, 2011

Murata, T., Aritake, K., Matsumoto, S., Kamauchi, S., Nakagawa, T., Hoir, M., Momotani, E., Urade, Y., Ozaki H.
Prostagladin D2 is a mast cell-derived anti-angiogenic factor in lung carcinoma.
Proc. Natl. Acad. Sci. USA. 108:19802-19807, 2011

Yanagie H, Kumada H, Nakamura T, Higashi S, Ikushima I, Morishita Y, Shinohara A, Fijihara M, Suzuki M, Sakurai Y, Sugiyama H, Kajiyama T, Nishimura R, Ono K, Nakajima J, Ono M, Eriguchi M, Takahashi H.
Feasibility evaluation of neutron capture therapy for hepatocellular carcinoma using selective enhancement of boron accumulation in tumour with intra-arterial administration of boron-entrapped water-in-oil-in-water emulsion.
Appl. Radiat. Isot. 69:1854-7, 2011

Takeuchi, Y., Fujino, Y., Watanabe, M., Nakagawa, T., Ohno, K., Sasaki, N., Sugano, S., Tsujimoto, H.
Screening of therapeutic targets for canine mast cell tumors from variety of kinase molecules.
J. Vet. Med. Sci. 73:1295-1302, 2011

Michishita, M., Akiyoshi, R., Yoshimura, H., Katsumoto, T., Ichikawa, H., Ohkusu-Tsukada, K.,
Nakagawa, T., Sasaki, N., Takahashi, K.
Chracterization of spheres derived from canine mammary gland adenocarcinoma cell lines.
Res. Vet. Sci. 91:251-253, 2011