• Neuroendocrine mechanism regulating ovulation and follicular development in female mammals
• Pathophysiological mechanism mediating suppressed gonadal activities under malnutrition
• Remodeling on mechanisms associated with pregnancy establishment
• Changes in placental structures through mammalian evolution
• Development of systems effective in improving reproductive efficiency

• Molecular and cellular analyses of mammalian gonadogenesis, testiculogenesis and spermatogenesis
• Roles of SOX (SRY-related HMG box) genes in mammalian embryogenesis and organogenesis

• Regulation of reproductive function by the neuron-endocrine-immune system
• Molecular mechanisms underlying sexual differentiation of the brain
• Neuroendocrine control of body growth and metabolism
• Regulatory mechanisms involved in growth and regeneration of skeletal muscle

• Signal transduction in the cells and its modification by drugs
• Pharmacological effects of bioactive natural products

• Studies on the mechanisms of persistent infection and reactivation of animal viruses and protozoas
• Development of recombinant vaccines for animals

• Control of zoonotic bacterial and viral pathogens in humans, livestock and foods
• Ecology and role of bacteria harboring in the intestine of human and animal

• Role of autonomic nervous system as a regulatory mechanism on cardiovascular function
• Examination of the sleep rhythm through the electroencephalographic analysis
• Analysis of the diabetes-resistant model rat
• Development of atrial fibrillation model animal and elucidation of the mechanism
• Studies on learning mechanism of aged animals

• Comparative neuropathology
• Comparative oncology
• Experimental and toxicologic pathology

• Molecular diagnostics of lymphoid and hematopoietic malignancies
• Pathogenesis of inflammatory gastrointestinal (GI) and Liver diseases
• Clinical application of acute phase proteins (APPs)

• Biological and translational research of tumors in small animals
• Regenerative therapy in veterinary medicine
• Anesthetic/analgesic and perioperative management in small animals

• Studies on viral infectious diseases in experimental animals
• Establishment and analysis of animal model of diseases

• Diagnosis and pathophysiology of central nervous system disorders
• Diagnostic and therapeutic studies on Diabetes
• Molecular basis of genetic disorders

• Regeneration of bone tissues using artificial bone implants
• Development of new treatment for osteoporosis
• Biological effects of trehalose

• Studies on pathogenesis of slow infection including viral cancer
• Studies on pathogen detection methods
• Studies on vaccine for controlling infectious diseases

• Immunopathological understanding of host-parasite relationship during protozoan diseases
• Development of drugs, vaccines and diagnostics for parasitic diseases
• Ecology and biology of sandflies as the vector for Leishmania

SUGIURA, Koji

• Reverse-genetic analyses of the mechanisms in mammalian oocyte growth, oocyte maturation, fertilization and early embryo development
• Molecular mechanisms of bi-directional communication between oocytes and surrounding somatic granulosa cells

• Studies on the molecular mechanisms underlying growth and differentiation of cell lineages
• Elucidation of the role of genomic DNA methylation in the epigenetic control of cellular differentiation development
• Investigation of molecular mechanism for the maintenance of totipotency and pluripotency in the stem cells, including ES, TS and EG cells
• Risk assessment of endocrine chemical disruptors for mammalian development

• Chemical communication via?pheromones in mammalian species
• Nature or nurture questions for?the personality formation
• Clinical studies in veterinary?behavior medicine

• Studies on pathophysiological effects of low-radiation studies on lipid-signaling in inflammation (tumor, allergy, tissue regeneration)

• Veterinary epidemiology, import risk assessment of animals and animal products, food safety risk assessment
• Vaccinology including mucosal delivary system, edible vaccines, immunogen formulation, and host immunity

• Safety and risk assessment of animal-derived foods including evaluation of radioactive contamination of livestock and livestock products due to the Fukushima Daiichi nuclear power plant accident
• Studies on regulation of microbial infection by sterilization of compost using ultra high temperature aerobic bacterial fermentation
• Studies on physiological characteristics of the ovary including research of molecular mechanism of oocyte selection in mammalian ovaries
• Studies on nutritional effect of amino acids on infantile growth in farm animals

• Genome-wide screening for the virulence markers of Streptococcus suis
• Surveillance of the Streptococcus suis virulent strains among healthy pigs and retail pork meat in Japan
• Functional analysis of genetic regions associated with fimbriation in Streptococcus suis
• Studies on the virulence mechanisms of Streptococcus gallolyticus of avian origin
• Development of a rapid detection system for bacterial pathogens associated with food poisoning

• Analysis of pathogenicity and species specificity of RNA viruses
• Analysis of mechanisms of RNA virus persistent infection
• Development of novel treatments for emerging lethal virus infections
• Development of new recombinant vaccines
• Development of recombinant viruses as oncolytic virotherapy agents